Effects of α-human atrial natriuretic polypeptide on vascular strips and perfused mesenteric vessels of SHR and WKY

These results show that α-hANP relaxed arterial strips but had no effect on pressor responses obtained in perfused mesenteric vessels. These results are similar to those of atripeptin II, a c-terminal deleted form of α-rANP (Kangawa et al.: BIOCH BIOPHYS RES COMN 121: 585-591, 1984) which relaxes ra...

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Bibliographic Details
Published in:	Japanese Heart Journal Vol. 26; no. 4; p. 695
Main Authors:	Mtabaji, Jacob P., Kobayashi, Yuta, Kihara, Masahiro, Nakao, Kazuwa, Sugawara, Akira, Suda, Mituaki, Morii, Narito, Sakamoto, Makoto, Shimokura, Masanori, Kiso, Yoshiaki, Imura, Hiroo, Yamori, Yukio, Hattori, Keisuke
Format:	Journal Article
Language:	English
Published:	International Heart Journal Association 1985
Online Access:	Get full text
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Summary:	These results show that α-hANP relaxed arterial strips but had no effect on pressor responses obtained in perfused mesenteric vessels. These results are similar to those of atripeptin II, a c-terminal deleted form of α-rANP (Kangawa et al.: BIOCH BIOPHYS RES COMN 121: 585-591, 1984) which relaxes rabbit aortic strips but has no effect on perfused rat hind limb vessels (Oshima et al.: CIRC RES 54: 612-616, 1984), suggesting atrial peptides may have little effects on resistance vessels. The difference observed in aged SHR cannot be explained purely on aging because no change was observed in aged WKY. It might be related to changes induced by the hypertensive state of the SHR.
ISSN:	0021-4868 1348-673X
DOI:	10.1536/ihj.26.695