Search Results - "Suda, Kojiro"
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Cytoplasmic zoning by protein phase transition after membrane permeabilization
Published in Journal of biochemistry (Tokyo) (25-02-2024)“…Abstract Biological membranes, including plasma membrane (PM) and organelle membranes, restrict the flux of ions, molecules and organelles. However, the…”
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Neuron-specific knockdown of Drosophila HADHB induces a shortened lifespan, deficient locomotive ability, abnormal motor neuron terminal morphology and learning disability
Published in Experimental cell research (15-06-2019)“…Mutations in the HADHB gene induce dysfunctions in the beta-oxidation of fatty acids and result in a MTP deficiency, which is characterized by clinical…”
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Novel roles of Drosophila FUS and Aub responsible for piRNA biogenesis in neuronal disorders
Published in Brain research (01-04-2019)“…•Aub overexpression enhanced mobility defects induced by the knockdown of Caz.•Caz plays a role in pre-piRNA production.•Knockdown of Caz produced abnormal…”
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Reduction of Rpd3 suppresses defects in locomotive ability and neuronal morphology induced by the knockdown of Drosophila SLC25A46 via an epigenetic pathway
Published in Experimental cell research (15-12-2019)“…Mitochondrial dysfunction causes various diseases. Mutations in the SLC25A46 gene have been identified in mitochondrial diseases that are sometimes classified…”
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Neuron-specific knockdown of solute carrier protein SLC25A46a induces locomotive defects, an abnormal neuron terminal morphology, learning disability, and shortened lifespan
Published in IBRO reports (01-06-2020)“…•Neuron-specific dSLC25A46a knockdown resulted in reduced mobility in larvae as well as adults.•Neuron-specific dSLC25A46a knockdown induced an aberrant…”
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Novel Drosophila model for mitochondrial diseases by targeting of a solute carrier protein SLC25A46
Published in Brain research (15-06-2018)“…•Novel Drosophila SLC25A46 knockdown model for mitochondrial diseases was developed.•Neuron-specific knockdown of dSLC25A46 results in locomotive…”
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Drosophila models to study causative genes for human rare intractable neurological diseases
Published in Experimental cell research (01-06-2021)“…Drosophila is emerging as a convenient model for investigating human diseases. Functional homologues of almost 75% of human disease-related genes are found in…”
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Genetic screening of the genes interacting with Drosophila FIG4 identified a novel link between CMT-causing gene and long noncoding RNAs
Published in Experimental neurology (01-12-2018)“…Neuron-specific knockdown of the dFIG4 gene, a Drosophila homologue of human FIG4 and one of the causative genes for Charcot-Marie-Tooth disease (CMT), reduces…”
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Plasma membrane damage limits replicative lifespan in yeast and induces premature senescence in human fibroblasts
Published in Nature aging (01-03-2024)“…Plasma membrane damage (PMD) occurs in all cell types due to environmental perturbation and cell-autonomous activities. However, cellular outcomes of PMD…”
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