Search Results - "Sud, Amit"

Epidemiology, genetics and treatment of multiple myeloma and precursor diseases by Hemminki, Kari, Försti, Asta, Houlston, Richard, Sud, Amit

“…Multiple myeloma (MM) is a hematological malignancy caused by the clonal expansion of plasma cells. The incidence of MM worldwide is increasing with greater…”
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Will polygenic risk scores for cancer ever be clinically useful? by Sud, Amit, Turnbull, Clare, Houlston, Richard

“…Genome-wide association studies (GWAS) have identified associations between common genetic variants, single nucleotide polymorphisms (SNPs) and the risk of…”
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Analysis of 153 115 patients with hematological malignancies refines the spectrum of familial risk by Sud, Amit, Chattopadhyay, Subhayan, Thomsen, Hauke, Sundquist, Kristina, Sundquist, Jan, Houlston, Richard S., Hemminki, Kari

“…Estimating familial cancer risks is clinically important in being able to discriminate between individuals in the population at differing risk for malignancy…”
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The clinical utility of polygenic risk scores for chronic lymphocytic leukemia by Sud, Amit, Law, Philip J., Houlston, Richard S.

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Survival trends in hematological malignancies in the Nordic countries through 50 years by Hemminki, Kari, Hemminki, Janne, Försti, Asta, Sud, Amit

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Phenome-wide Mendelian randomisation analysis of 378,142 cases reveals risk factors for eight common cancers by Went, Molly, Sud, Amit, Mills, Charlie, Hyde, Abi, Culliford, Richard, Law, Philip, Vijayakrishnan, Jayaram, Gockel, Ines, Maj, Carlo, Schumacher, Johannes, Palles, Claire, Kaiser, Martin, Houlston, Richard

“…For many cancers there are only a few well-established risk factors. Here, we use summary data from genome-wide association studies (GWAS) in a Mendelian…”
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Whole genome sequencing refines stratification and therapy of patients with clear cell renal cell carcinoma by Culliford, Richard, Lawrence, Samuel E. D., Mills, Charlie, Tippu, Zayd, Chubb, Daniel, Cornish, Alex J., Browning, Lisa, Kinnersley, Ben, Bentham, Robert, Sud, Amit, Pallikonda, Husayn, Frangou, Anna, Gruber, Andreas J., Litchfield, Kevin, Wedge, David, Larkin, James, Turajlic, Samra, Houlston, Richard S.

“…Clear cell renal cell carcinoma (ccRCC) is the most common form of kidney cancer, but a comprehensive description of its genomic landscape is lacking. We…”
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Deciphering the genetics and mechanisms of predisposition to multiple myeloma by Went, Molly, Duran-Lozano, Laura, Halldorsson, Gisli H., Gunnell, Andrea, Ugidos-Damboriena, Nerea, Law, Philip, Ekdahl, Ludvig, Sud, Amit, Thorleifsson, Gudmar, Thodberg, Malte, Olafsdottir, Thorunn, Lamarca-Arrizabalaga, Antton, Cafaro, Caterina, Niroula, Abhishek, Ajore, Ram, Lopez de Lapuente Portilla, Aitzkoa, Ali, Zain, Pertesi, Maroulio, Goldschmidt, Hartmut, Stefansdottir, Lilja, Kristinsson, Sigurdur Y., Stacey, Simon N., Love, Thorvardur J., Rognvaldsson, Saemundur, Hajek, Roman, Vodicka, Pavel, Pettersson-Kymmer, Ulrika, Späth, Florentin, Schinke, Carolina, Van Rhee, Frits, Sulem, Patrick, Ferkingstad, Egil, Hjorleifsson Eldjarn, Grimur, Mellqvist, Ulf-Henrik, Jonsdottir, Ingileif, Morgan, Gareth, Sonneveld, Pieter, Waage, Anders, Weinhold, Niels, Thomsen, Hauke, Försti, Asta, Hansson, Markus, Juul-Vangsted, Annette, Thorsteinsdottir, Unnur, Hemminki, Kari, Kaiser, Martin, Rafnar, Thorunn, Stefansson, Kari, Houlston, Richard, Nilsson, Björn

“…Multiple myeloma (MM) is an incurable malignancy of plasma cells. Epidemiological studies indicate a substantial heritable component, but the underlying…”
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Using Mendelian Randomisation to search for modifiable risk factors influencing the development of clonal haematopoiesis by Hislop, Jessica M., Went, Molly, Mills, Charlie, Sud, Amit, Law, Philip J., Houlston, Richard S.

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T-cell Prolymphocytic Leukemia by Sud, Amit, MBChB, MRes, MRCP, Dearden, Claire, BSc, MBBS, MD, FRCP, FRCPath

“…T-cell prolymphocytic leukemia (T-PLL) is a rare and aggressive T-cell malignancy. T-PLL can be distinguished from other lymphoid diseases by the evaluation…”
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Impact of atopy on risk of glioma: a Mendelian randomisation study by Disney-Hogg, Linden, Cornish, Alex J, Sud, Amit, Law, Philip J, Kinnersley, Ben, Jacobs, Daniel I, Ostrom, Quinn T, Labreche, Karim, Eckel-Passow, Jeanette E, Armstrong, Georgina N, Claus, Elizabeth B, Il'yasova, Dora, Schildkraut, Joellen, Barnholtz-Sloan, Jill S, Olson, Sara H, Bernstein, Jonine L, Lai, Rose K, Schoemaker, Minouk J, Simon, Matthias, Hoffmann, Per, Nöthen, Markus M, Jöckel, Karl-Heinz, Chanock, Stephen, Rajaraman, Preetha, Johansen, Christoffer, Jenkins, Robert B, Melin, Beatrice S, Wrensch, Margaret R, Sanson, Marc, Bondy, Melissa L, Houlston, Richard S

“…An inverse relationship between allergies with glioma risk has been reported in several but not all epidemiological observational studies. We performed an…”
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Polygenic risk scores to stratify cancer screening should predict mortality not incidence by Vickers, Andrew J., Sud, Amit, Bernstein, Jonine, Houlston, Richard

“…Population-based cancer screening programs such as mammography or colonscopy generally directed at all healthy individuals in a given age stratum. It has…”
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Mendelian randomization provides support for obesity as a risk factor for meningioma by Takahashi, Hannah, Cornish, Alex J., Sud, Amit, Law, Philip J., Disney-Hogg, Linden, Calvocoressi, Lisa, Lu, Lingeng, Hansen, Helen M., Smirnov, Ivan, Walsh, Kyle M., Schramm, Johannes, Hoffmann, Per, Nöthen, Markus M., Jöckel, Karl-Heinz, Schildkraut, Joellen M., Simon, Matthias, Bondy, Melissa, Wrensch, Margaret, Wiemels, Joseph L., Claus, Elizabeth B., Turnbull, Clare, Houlston, Richard S.

“…Little is known about the causes of meningioma. Obesity and obesity-related traits have been reported in several epidemiological observational studies to be…”
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Familial risks of acute myeloid leukemia, myelodysplastic syndromes, and myeloproliferative neoplasms by Sud, Amit, Chattopadhyay, Subhayan, Thomsen, Hauke, Sundquist, Kristina, Sundquist, Jan, Houlston, Richard S., Hemminki, Kari

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Genetic landscape of interval and screen detected breast cancer by Mills, Charlie, Sud, Amit, Everall, Andrew, Chubb, Daniel, Lawrence, Samuel E. D., Kinnersley, Ben, Cornish, Alex J., Bentham, Robert, Houlston, Richard S.

“…Interval breast cancers (IBCs) are cancers diagnosed between screening episodes. Understanding the biological differences between IBCs and screen-detected…”
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A retrospective study of MYC rearranged diffuse large B-cell lymphoma in the context of the new WHO and ICC classifications by El-Sharkawi, Dima, Sud, Amit, Prodger, Catherine, Khwaja, Jahanzaib, Shotton, Rohan, Hanley, Brian, Peacock, Victoria, Peng, Ying Ying, Arasaretnam, Anita, Sharma, Sarkhara, Aldridge, Frances, Sharma, Bhupinder, Wotherspoon, Andrew, Cheung, Betty, De Lord, Corinne, Johnston, Rosalynd, Kassam, Shireen, Pettengel, Ruth, Linton, Kim, Greaves, Paul, Cook, Lucy, Naresh, Kikkeri N., Cwynarski, Kate, Eyre, Toby A., Chau, Ian, Cunningham, David, Iyengar, Sunil

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The Primordial Growth Disorder 3-M Syndrome Connects Ubiquitination to the Cytoskeletal Adaptor OBSL1 by Hanson, Dan, Murray, Philip G., Sud, Amit, Temtamy, Samia A., Aglan, Mona, Superti-Furga, Andrea, Holder, Sue E., Urquhart, Jill, Hilton, Emma, Manson, Forbes D.C., Scambler, Peter, Black, Graeme C.M., Clayton, Peter E.

“…3-M syndrome is an autosomal-recessive primordial growth disorder characterized by significant intrauterine and postnatal growth restriction. Mutations in the…”
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Genetic Predisposition to Multiple Myeloma at 5q15 Is Mediated by an ELL2 Enhancer Polymorphism by Li, Ni, Johnson, David C., Weinhold, Niels, Kimber, Scott, Dobbins, Sara E., Mitchell, Jonathan S., Kinnersley, Ben, Sud, Amit, Law, Philip J., Orlando, Giulia, Scales, Matthew, Wardell, Christopher P., Försti, Asta, Hoang, Phuc H., Went, Molly, Holroyd, Amy, Hariri, Fadi, Pastinen, Tomi, Meissner, Tobias, Goldschmidt, Hartmut, Hemminki, Kari, Morgan, Gareth J., Kaiser, Martin, Houlston, Richard S.

“…Multiple myeloma (MM) is a malignancy of plasma cells. Genome-wide association studies have shown that variation at 5q15 influences MM risk. Here, we have…”
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Multiple myeloma: family history and mortality in second primary cancers by Chattopadhyay, Subhayan, Yu, Hongyao, Sud, Amit, Sundquist, Jan, Försti, Asta, Hemminki, Akseli, Hemminki, Kari

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Transcriptome-wide association study of multiple myeloma identifies candidate susceptibility genes by Went, Molly, Kinnersley, Ben, Sud, Amit, Johnson, David C, Weinhold, Niels, Försti, Asta, van Duin, Mark, Orlando, Giulia, Mitchell, Jonathan S, Kuiper, Rowan, Walker, Brian A, Gregory, Walter M, Hoffmann, Per, Jackson, Graham H, Nöthen, Markus M, da Silva Filho, Miguel Inacio, Thomsen, Hauke, Broyl, Annemiek, Davies, Faith E, Thorsteinsdottir, Unnur, Hansson, Markus, Kaiser, Martin, Sonneveld, Pieter, Goldschmidt, Hartmut, Stefansson, Kari, Hemminki, Kari, Nilsson, Björn, Morgan, Gareth J, Houlston, Richard S

“…While genome-wide association studies (GWAS) of multiple myeloma (MM) have identified variants at 23 regions influencing risk, the genes underlying these…”
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