Colostrum immunoglobulins and oxidative capacity may be affected by infant sex and maternal age and parity

The aims of this study were to determine the levels of the total antioxidant status (TAS), the total oxidant status (TOS), the oxidative stress index (OSI), and the concentration of immunoglobulin A (IgA) and M (IgM) in colostrum, and evaluate relationships between these parameters and maternal age,...

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Bibliographic Details
Published in:	Turkish journal of medical sciences Vol. 49; no. 1; pp. 87 - 92
Main Authors:	Kaplan, Davut Sinan, Bağcı, Cahit, Örkmez, Mustafa, Kömürcü Karuserci, Özge, Sucu, Seyhan, Çelik, Hakim, Taysı, Seyithan
Format:	Journal Article
Language:	English
Published:	Turkey The Scientific and Technological Research Council of Turkey 11-02-2019
Subjects:	Adult Antioxidants - analysis Cohort Studies Colostrum - chemistry Female Humans Immunoglobulin A - analysis Immunoglobulin M - analysis Infant, Newborn Male Maternal Age Oxidative Stress Parity - physiology Sex Factors Young Adult breast milk Total antioxidant status total oxidant status
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Summary:	The aims of this study were to determine the levels of the total antioxidant status (TAS), the total oxidant status (TOS), the oxidative stress index (OSI), and the concentration of immunoglobulin A (IgA) and M (IgM) in colostrum, and evaluate relationships between these parameters and maternal age, maternal parity, and infant sex. The analysis was performed in serum samples of colostrum which were collected from 90 mothers on the first day of lactation between 10:00 and 12:00 AM The measurements established that no significant association existed between the TAS level of colostrum and parity, maternal age, or infant sex. However, mothers 18 to 30 years of age had significantly lower colostrum TOS and OSI levels compared with mothers older than 30 years of age. IgA and IgM values of the colostrum of primiparous mothers were significantly higher than those of multiparous mothers, whereas no correlations existed with the age of the mother. Additionally, significantly higher colostrum IgA and IgM values were observed in female infants fed colostrum compared with male infants. In conclusion, sex-based hormonal changes in mothers during pregnancy may be associated with the different colostral immunoglobulin levels for male and female infants.
Bibliography:	none declared CONFLICT OF INTEREST
ISSN:	1300-0144 1303-6165
DOI:	10.3906/sag-1810-66