Search Results - "Sucov, Henry M."

Frequency of mononuclear diploid cardiomyocytes underlies natural variation in heart regeneration by Patterson, Michaela, Barske, Lindsey, Van Handel, Ben, Rau, Christoph D, Gan, Peiheng, Sharma, Avneesh, Parikh, Shan, Denholtz, Matt, Huang, Ying, Yamaguchi, Yukiko, Shen, Hua, Allayee, Hooman, Crump, J Gage, Force, Thomas I, Lien, Ching-Ling, Makita, Takako, Lusis, Aldons J, Kumar, S Ram, Sucov, Henry M

“…Henry Sucov and colleagues demonstrate substantial natural variation in the capacity of the mouse heart to regenerate after injury and link this to the…”
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Adipogenesis and epicardial adipose tissue: A novel fate of the epicardium induced by mesenchymal transformation and PPARγ activation by Yamaguchi, Yukiko, Cavallero, Susana, Patterson, Michaela, Shen, Hua, Xu, Jian, Kumar, S. Ram, Sucov, Henry M.

“…Significance A layer of fat surrounds the heart in most mammals, including humans. The biology of this tissue has been speculated for centuries, but never…”
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CXCL12 Signaling Is Essential for Maturation of the Ventricular Coronary Endothelial Plexus and Establishment of Functional Coronary Circulation by Cavallero, Susana, Shen, Hua, Yi, Christopher, Lien, Ching-Ling, Kumar, S. Ram, Sucov, Henry M.

“…Maturation of a vascular plexus is a critical and yet incompletely understood process in organ development, and known maturation factors act universally in all…”
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Endocardium Minimally Contributes to Coronary Endothelium in the Embryonic Ventricular Free Walls by Zhang, Hui, Pu, Wenjuan, Li, Guang, Huang, Xiuzhen, He, Lingjuan, Tian, Xueying, Liu, Qiaozhen, Zhang, Libo, Wu, Sean M, Sucov, Henry M, Zhou, Bin

“…RATIONALE:There is persistent uncertainty regarding the developmental origins of coronary vessels, with 2 principal sources suggested as ventricular…”
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Defects in placental syncytiotrophoblast cells are a common cause of developmental heart disease by Radford, Bethany N., Zhao, Xiang, Glazer, Tali, Eaton, Malcolm, Blackwell, Danielle, Mohammad, Shuhiba, Lo Vercio, Lucas Daniel, Devine, Jay, Shalom-Barak, Tali, Hallgrimsson, Benedikt, Cross, James C., Sucov, Henry M., Barak, Yaacov, Dean, Wendy, Hemberger, Myriam

“…Placental abnormalities have been sporadically implicated as a source of developmental heart defects. Yet it remains unknown how often the placenta is at the…”
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A natural loss-of-function deletion of the cytohesin 1 (Cyth1) gene in BALB/cByJ mice does not impact cardiomyocyte polyploidy by Song, Ruolan, Watanabe, Hirofumi, Tjen, Kelsey, Westbury, Baylee C., Makita, Takako, Tao, Ge, Sucov, Henry M.

“…Mammalian cardiomyocytes (CMs) mostly become polyploid shortly after birth. Because this feature may relate to several aspects of heart biology, including…”
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Nkx2-5 regulates cardiac growth through modulation of Wnt signaling by R-spondin3 by Cambier, Linda, Plate, Markus, Sucov, Henry M, Pashmforoush, Mohammad

“…A complex regulatory network of morphogens and transcription factors is essential for normal cardiac development. Nkx2-5 is among the earliest known markers of…”
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PRMT1-p53 Pathway Controls Epicardial EMT and Invasion by Jackson-Weaver, Olan, Ungvijanpunya, Nicha, Yuan, Yuan, Qian, Jiang, Gou, Yongchao, Wu, Jian, Shen, Hua, Chen, Yibu, Li, Meng, Richard, Stéphane, Chai, Yang, Sucov, Henry M., Xu, Jian

“…Epicardial cells are cardiac progenitors that give rise to the majority of cardiac fibroblasts, coronary smooth muscle cells, and pericytes during development…”
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Igf Signaling is Required for Cardiomyocyte Proliferation during Zebrafish Heart Development and Regeneration by Huang, Ying, Harrison, Michael R, Osorio, Arthela, Kim, Jieun, Baugh, Aaron, Duan, Cunming, Sucov, Henry M, Lien, Ching-Ling

“…Unlike its mammalian counterpart, the adult zebrafish heart is able to fully regenerate after severe injury. One of the most important events during the…”
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CITED2 is a conserved regulator of the uterine-placental interface by Kuna, Marija, Dhakal, Pramod, Iqbal, Khursheed, Dominguez, Esteban M, Kent, Lindsey N, Muto, Masanaga, Moreno-Irusta, Ayelen, Kozai, Keisuke, Varberg, Kaela M, Okae, Hiroaki, Arima, Takahiro, Sucov, Henry M, Soares, Michael J

“…Establishment of the hemochorial uterine-placental interface requires exodus of trophoblast cells from the placenta and their transformative actions on the…”
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Phases and Mechanisms of Embryonic Cardiomyocyte Proliferation and Ventricular Wall Morphogenesis by Barak, Yaacov, Hemberger, Myriam, Sucov, Henry M.

“…If viewed as a movie, heart morphogenesis appears to unfold in a continuous and seamless manner. At the mechanistic level, however, a series of discreet and…”
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IGF signaling directs ventricular cardiomyocyte proliferation during embryonic heart development by Li, Peng, Cavallero, Susana, Gu, Ying, Chen, Tim H P, Hughes, Jennifer, Hassan, A Bassim, Brüning, Jens C, Pashmforoush, Mohammad, Sucov, Henry M

“…Secreted factors from the epicardium are believed to be important in directing heart ventricular cardiomyocyte proliferation and morphogenesis, although the…”
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Tnni3k alleles influence ventricular mononuclear diploid cardiomyocyte frequency by Gan, Peiheng, Patterson, Michaela, Velasquez, Alexa, Wang, Kristy, Tian, Di, Windle, Jolene J, Tao, Ge, Judge, Daniel P, Makita, Takako, Park, Thomas J, Sucov, Henry M

“…Recent evidence implicates mononuclear diploid cardiomyocytes as a proliferative and regenerative subpopulation of the postnatal heart. The number of these…”
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Mesenchymal origin of hepatic stellate cells, submesothelial cells, and perivascular mesenchymal cells during mouse liver development by Asahina, Kinji, Tsai, Shirley Y., Li, Peng, Ishii, Mamoru, Maxson, Robert E., Sucov, Henry M., Tsukamoto, Hidekazu

“…The knowledge concerning fetal hepatic stellate cells (HSCs) is scarce, and their cell lineage and functions are largely unknown. The current study isolated…”
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Endothelins are vascular-derived axonal guidance cues for developing sympathetic neurons by Ginty, David D, Makita, Takako, Sucov, Henry M, Gariepy, Cheryl E, Yanagisawa, Masashi

“…During development, sympathetic neurons extend axons along a myriad of distinct trajectories, often consisting of arteries, to innervate one of a large variety…”
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Mononuclear diploid cardiomyocytes support neonatal mouse heart regeneration in response to paracrine IGF2 signaling by Shen, Hua, Gan, Peiheng, Wang, Kristy, Darehzereshki, Ali, Wang, Kai, Kumar, S Ram, Lien, Ching-Ling, Patterson, Michaela, Tao, Ge, Sucov, Henry M

“…Injury to the newborn mouse heart is efficiently regenerated, but this capacity is lost by one week after birth. We found that IGF2, an important mitogen in…”
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Allelic variants between mouse substrains BALB/cJ and BALB/cByJ influence mononuclear cardiomyocyte composition and cardiomyocyte nuclear ploidy by Gan, Peiheng, Patterson, Michaela, Watanabe, Hirofumi, Wang, Kristy, Edmonds, Reilly A., Reinholdt, Laura G., Sucov, Henry M.

“…Most mouse cardiomyocytes (CMs) become multinucleated shortly after birth via endoreplication and interrupted mitosis, which persists through adulthood. The…”
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Cardiomyocyte Polyploidy and Implications for Heart Regeneration by Gan, Peiheng, Patterson, Michaela, Sucov, Henry M

“…In mammals, most cardiomyocytes (CMs) become polyploid (they have more than two complete sets of chromosomes). The purpose of this review is to evaluate…”
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Endothelial neuropilin disruption in mice causes DiGeorge syndrome-like malformations via mechanisms distinct to those caused by loss of Tbx1 by Zhou, Jingjing, Pashmforoush, Mohammad, Sucov, Henry M

“…The spectrum of human congenital malformations known as DiGeorge syndrome (DGS) is replicated in mice by mutation of Tbx1. Vegfa has been proposed as a…”
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Cardiomyocyte-fibroblast interaction regulates ferroptosis and fibrosis after myocardial injury by Mohr, Mary E., Li, Shuang, Trouten, Allison M., Stairley, Rebecca A., Roddy, Patrick L., Liu, Chun, Zhang, Min, Sucov, Henry M., Tao, Ge

“…Neonatal mouse hearts have transient renewal capacity, which is lost in juvenile and adult stages. In neonatal mouse hearts, myocardial infarction (MI) causes…”
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