Search Results - "Suckling, Richard J"
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Structural and functional dissection of the interplay between lipid and Notch binding by human Notch ligands
Published in The EMBO journal (01-08-2017)“…Recent data have expanded our understanding of Notch signalling by identifying a C2 domain at the N‐terminus of Notch ligands, which has both lipid‐ and…”
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Structural basis for the binding of tryptophan-based motifs by δ-COP
Published in Proceedings of the National Academy of Sciences - PNAS (17-11-2015)“…Coatomer consists of two subcomplexes: the membrane-targeting, ADP ribosylation factor 1 (Arf1):GTP-binding βγδζ-COP F-subcomplex, which is related to the…”
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dE2F2-Independent Rescue of Proliferation in Cells Lacking an Activator dE2F1
Published in Molecular and Cellular Biology (01-12-2007)“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Instability of the HLA-E peptidome of HIV presents a major barrier to therapeutic targeting
Published in Molecular therapy (06-03-2024)“…Naturally occurring T cells that recognize microbial peptides via HLA-E, a nonpolymorphic HLA class Ib molecule, could provide the foundation for new universal…”
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Promiscuous recognition of MR1 drives self-reactive mucosal-associated invariant T cell responses
Published in The Journal of experimental medicine (04-09-2023)“…Mucosal-associated invariant T (MAIT) cells use canonical semi-invariant T cell receptors (TCR) to recognize microbial riboflavin precursors displayed by the…”
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Immune‐Mobilizing Monoclonal T Cell Receptors Mediate Specific and Rapid Elimination of Hepatitis B–Infected Cells
Published in Hepatology (Baltimore, Md.) (01-11-2020)“…Background and Aims Therapies for chronic hepatitis B virus (HBV) infection are urgently needed because of viral integration, persistence of viral antigen…”
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Viral sequence determines HLA-E-restricted T cell recognition of hepatitis B surface antigen
Published in Nature communications (22-11-2024)“…The non-polymorphic HLA-E molecule offers opportunities for new universal immunotherapeutic approaches to chronic infectious diseases. Chronic Hepatitis B…”
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A novel HFE mutation (c.del478) results in nonsense-mediated decay of the mutant transcript in a hemochromatosis patient
Published in Blood cells, molecules, & diseases (01-09-2009)“…On admission to hospital Caucasian 61 year old male with jaundice was found to have unexplained increased serum iron indices. He had bilateral peripheral…”
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Structural basis for the binding of tryptophan-based motifs by [delta]-COP
Published in Proceedings of the National Academy of Sciences - PNAS (17-11-2015)“…Anion channelrhodopsins (ACRs) are a class of light-gated channels recently identified in cryptophyte algae that provide unprecedented fast and powerful…”
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