Search Results - "Sucher, N J"

Selective alterations in gene expression for NMDA receptor subunits in prefrontal cortex of schizophrenics by Akbarian, S, Sucher, NJ, Bradley, D, Tafazzoli, A, Trinh, D, Hetrick, WP, Potkin, SG, Sandman, CA, Bunney, WE, Jr, Jones, EG

“…NMDA receptor antagonists can induce a schizophrenia-like psychosis, but the role of NMDA receptors in the pathophysiology of schizophrenia remains unclear…”
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Neuroprotective effects of tanshinones in transient focal cerebral ischemia in mice by Lam, B.Y.H., Lo, A.C.Y., Sun, X., Luo, H.W., Chung, S.K., Sucher, N.J.

“…Tanshinones are the major lipid soluble pharmacological constituents of Danshen, the dried roots of Salvia miltiorrhiza Bunge (Labiatae), a well known…”
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Stroke therapy in traditional Chinese medicine (TCM): prospects for drug discovery and development by Gong, X., Sucher, N.J.

“…Brain injuries resulting from stroke are a major and increasing public health problem in both developed and developing countries worldwide. China's extensive…”
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Developmental and regional expression pattern of a novel NMDA receptor- like subunit (NMDAR-L) in the rodent brain by Sucher, NJ, Akbarian, S, Chi, CL, Leclerc, CL, Awobuluyi, M, Deitcher, DL, Wu, MK, Yuan, JP, Jones, EG, Lipton, SA

“…A novel NMDA receptor-like (NMDAR-L) cDNA was isolated that contained an open reading frame coding for a predicted polypeptide of 1115 amino acids that shares…”
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N-methyl-D-aspartate receptors are critical for mediating the effects of glutamate on intracellular calcium concentration and immediate early gene expression in cultured hippocampal neurons by BADING, H, SEGAL, M. M, SUCHER, N. J, DUDEK, H, LIPTON, S. A, GREENBERG, M. E

“…The mechanisms by which activation of excitatory amino acid receptors is coupled to the regulation of gene transcription were studied using cultured…”
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Effect of nitric oxide production on the redox modulatory site of the NMDA receptor-channel complex by Lei, S Z, Pan, Z H, Aggarwal, S K, Chen, H S, Hartman, J, Sucher, N J, Lipton, S A

“…Nitric oxide (NO) is an important messenger both systemically and in the CNS. In digital Ca2+ imaging and patch-clamp experiments, clinically available nitroso…”
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NMDA receptors: from genes to channels by Sucher, N J, Awobuluyi, M, Choi, Y B, Lipton, S A

“…N-methyl-D-aspartate receptors belong to the family of ionotropic glutamate receptors. NMDA receptors were named after the specific glutamate-like synthetic…”
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Traditional Chinese medicines with caspase-inhibitory activity by Fattorusso, R., Frutos, S., Sun, X., Sucher, N.J., Pellecchia, M.

“…Clinical evidence indicates that traditional Chinese medicine (TCM) drugs can reduce stroke-inflicted brain damage. To date, the molecular basis of the…”
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Redox modulatory site of the NMDA receptor-channel complex: regulation by oxidized glutathione by Sucher, N J, Lipton, S A

“…We monitored increases in both intracellular calcium concentration [( Ca2+]i) and whole-cell current responses induced by N-methyl-D-aspartate (NMDA), applied…”
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Synergistic effects of HIV coat protein and NMDA receptor-mediated neurotoxicity by Lipton, S A, Sucher, N J, Kaiser, P K, Dreyer, E B

“…Exposure of rat retinal cultures to HIV-1 coat protein gp120 for several minutes increases [Ca2+]i in approximately half of the ganglion cells; this effect is…”
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Activation of NMDA receptor-channels in human retinal Müller glial cells inhibits inward-rectifying potassium currents by Puro, D G, Yuan, J P, Sucher, N J

“…Although it is well known that neurotransmitters mediate neuron-to-neuron communication, it is becoming clear that neurotransmitters also affect glial cells…”
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Flavonoids from Radix Scutellariae as potential stroke therapeutic agents by targeting the second postsynaptic density 95 (PSD-95)/disc large/zonula occludens-1 (PDZ) domain of PSD-95 by Tang, W., Sun, X., Fang, J.-S., Zhang, M., Sucher, N.J.

“…Excessive activation of N-methyl-D-aspartate receptors (NMDARs) and subsequent production of nitric oxide by neuronal nitric oxide synthase (nNOS) contribute…”
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Magnesium as NMDA receptor blocker in the traditional Chinese medicine Danshen by Sun, X., Chan, L.N., Sucher, N.J.

“…Aqueous extracts of the traditional Chinese medicine Danshen, the dried roots of Salvia miltiorrhiza Bunge (Labiatae), blocked N-methyl- d-aspartate (NMDA)…”
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Redox modulation of the NMDA receptor by NO-related species by Lipton, S A, Rayudu, P V, Choi, Y B, Sucher, N J, Chen, H S

“…The chemical reactions of NO are largely dictated by its redox state. Increasing evidence suggests that the various redox states of the NO group exist…”
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(S)NO Signals: Translocation, Regulation, and a Consensus Motif by Stamler, Jonathan S., Toone, Eric J., Lipton, Stuart A., Sucher, Nikolaus J.

“…Nitric oxide (NO) is a signaling molecule that has captured our imagination. According to the common view, NO diffuses over a large sphere of influence, moving…”
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N-methyl-D-aspartate antagonists prevent kainate neurotoxicity in rat retinal ganglion cells in vitro by Sucher, NJ, Aizenman, E, Lipton, SA

“…Under defined culture conditions, exogenous glutamate (Glu), NMDA, or an endogenous Glu-related toxin is lethal to rat retinal ganglion cells; these…”
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Redox state, NMDA receptors and NO-related species by Lipton, S A, Choi, Y B, Sucher, N J, Pan, Z H, Stamler, J S

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Assembly with the NR1 Subunit Is Required for Surface Expression of NR3A-Containing NMDA Receptors by Perez-Otano, Isabel, Schulteis, Christine T, Contractor, Anis, Lipton, Stuart A, Trimmer, James S, Sucher, Nikolaus J, Heinemann, Stephen F

“…Functional NMDA receptors are heteromultimeric complexes of the NR1 subunit in combination with at least one of the four NR2 subunits (A-D). Coexpression of…”
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Molecular basis of glutamate toxicity in retinal ganglion cells by Sucher, Nikolaus J., Lipton, Stuart A., Dreyer, Evan B.

“…Loss of retinal ganglion cells (RGCs) is a hallmark of many ophthalmic diseases including glaucoma, retinal ischemia due to central artery occlusion, anterior…”
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Calcium channel antagonists attenuate NMDA receptor-mediated neurotoxicity of retinal ganglion cells in culture by Sucher, N J, Lei, S Z, Lipton, S A

“…Dihydropyridine calcium channel antagonists block a prolonged or 'L-type' component of voltage-dependent Ca2+ current in patch-clamp recordings of postnatal…”
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