Search Results - "Suchard, Suzanne"

Circulating T Cell Subpopulations Correlate With Immune Responses at the Tumor Site and Clinical Response to PD1 Inhibition in Non-Small Cell Lung Cancer by Manjarrez-Orduño, Nataly, Menard, Laurence C, Kansal, Selena, Fischer, Paul, Kakrecha, Bijal, Jiang, Can, Cunningham, Mark, Greenawalt, Danielle, Patel, Vishal, Yang, Minghui, Golhar, Ryan, Carman, Julie A, Lezhnin, Sergey, Dai, Hongyue, Kayne, Paul S, Suchard, Suzanne J, Bernstein, Steven H, Nadler, Steven G

“…Agents targeting the PD1-PDL1 axis have transformed cancer therapy. Factors that influence clinical response to PD1-PDL1 inhibitors include tumor mutational…”
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Inhibition of Donor-Reactive CD8+ T Cell Responses by Selective CD28 Blockade Is Independent of Reduced ICOS Expression by Liu, Danya, Suchard, Suzanne J, Nadler, Steve G, Ford, Mandy L

“…Programmed T cell differentiation is critically influenced by the complement of costimulatory and coinhibitory signals transmitted during initial antigen…”
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2B4 (CD244) induced by selective CD28 blockade functionally regulates allograft-specific CD8+ T cell responses by Liu, Danya, Krummey, Scott M, Badell, I Raul, Wagener, Maylene, Schneeweis, Lumelle A, Stetsko, Dawn K, Suchard, Suzanne J, Nadler, Steven G, Ford, Mandy L

“…Mounting evidence in models of both autoimmunity and chronic viral infection suggests that the outcome of T cell activation is critically impacted by the…”
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A monovalent anti-human CD28 domain antibody antagonist: preclinical efficacy and safety by Suchard, Suzanne J, Davis, Patricia M, Kansal, Selena, Stetsko, Dawn K, Brosius, Ruth, Tamura, James, Schneeweis, Lumelle, Bryson, James, Salcedo, Theodora, Wang, Haiqing, Yang, Zheng, Fleener, Catherine A, Ignatovich, Olga, Plummer, Christopher, Grant, Steven, Nadler, Steven G

“…Targeting the CD28-CD80/86 pathway with an anti-CD28 antagonist is a promising alternative to current therapies for autoimmunity. However, attempts at…”
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Assessment of Belatacept-Mediated Costimulation Blockade Through Evaluation of CD80/86-Receptor Saturation by LATEK, Robert, FLEENER, Catherine, LAMIAN, Vahideh, KULBOKAS, Edward, DAVIS, Patricia M, SUCHARD, Suzanne J, CURRAN, Mark, VINCENTI, Flavio, TOWNSEND, Robert

“…The selective inhibitor of T-cell costimulation, belatacept, blocks CD28-mediated T-cell activation by binding CD80 and CD86 on antigen-presenting cells…”
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Functional Antagonism of Human CD40 Achieved by Targeting a Unique Species-Specific Epitope by Yamniuk, Aaron P., Suri, Anish, Krystek, Stanley R., Tamura, James, Ramamurthy, Vidhyashankar, Kuhn, Robert, Carroll, Karen, Fleener, Catherine, Ryseck, Rolf, Cheng, Lin, An, Yongmi, Drew, Philip, Grant, Steven, Suchard, Suzanne J., Nadler, Steven G., Bryson, James W., Sheriff, Steven

“…Current clinical anti-CD40 biologic agents include both antagonist molecules for the treatment of autoimmune diseases and agonist molecules for…”
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Engineering of a novel anti-CD40L domain antibody for treatment of autoimmune diseases by Xie, Jenny H, Yamniuk, Aaron P, Borowski, Virna, Kuhn, Robert, Susulic, Vojkan, Rex-Rabe, Sandra, Yang, Xiaoxia, Zhou, Xiadi, Zhang, Yifan, Gillooly, Kathleen, Brosius, Ruth, Ravishankar, Rathna, Waggie, Kimberly, Mink, Kathy, Price, Laura, Rehfuss, Robert, Tamura, James, An, Yongmi, Cheng, Lin, Abramczyk, Bozena, Ignatovich, Olga, Drew, Philip, Grant, Steven, Bryson, James W, Suchard, Suzanne, Salter-Cid, Luisa, Nadler, Steven, Suri, Anish

“…CD40-CD40L interactions play a critical role in regulating immune responses. Blockade of CD40L by Abs, such as the anti-CD40L Ab 5c8, demonstrated positive…”
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Abatacept binds to the Fc receptor CD64 but does not mediate complement-dependent cytotoxicity or antibody-dependent cellular cytotoxicity by DAVIS, Patricia M, ABRAHAM, Ralph, LINDA XU, NADLER, Steven G, SUCHARD, Suzanne J

“…OBJECTIVE: To assess the ability of abatacept to mediate complement-dependent cytotoxicity (CDC) or antibody-dependent cellular cytotoxicity (ADCC) of…”
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Integrated Pharmacokinetic/Pharmacodynamic Analysis for Determining the Minimal Anticipated Biological Effect Level of a Novel Anti-CD28 Receptor Antagonist BMS-931699 by Yang, Zheng, Wang, Haiqing, Salcedo, Theodora W, Suchard, Suzanne J, Xie, Jenny H, Schneeweis, Lumelle A, Fleener, Catherine A, Calore, James D, Shi, Rong, Zhang, Sean X Y, Rodrigues, A David, Car, Bruce D, Marathe, Punit H, Nadler, Steven G

“…BMS-931699 (lulizumab pegol), a domain antibody (dAb) conjugated with 40-kDa branched polyethylene glycol, is a human anti-CD28 receptor antagonist under…”
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Potent and Selective Agonists of Sphingosine 1‑Phosphate 1 (S1P1): Discovery and SAR of a Novel Isoxazole Based Series by Watterson, Scott H, Guo, Junqing, Spergel, Steve H, Langevine, Charles M, Moquin, Robert V, Shen, Ding Ren, Yarde, Melissa, Cvijic, Mary Ellen, Banas, Dana, Liu, Richard, Suchard, Suzanne J, Gillooly, Kathleen, Taylor, Tracy, Rex-Rabe, Sandra, Shuster, David J, McIntyre, Kim W, Cornelius, Georgia, D’Arienzo, Celia, Marino, Anthony, Balimane, Praveen, Warrack, Bethanne, Salter-Cid, Luisa, McKinnon, Murray, Barrish, Joel C, Carter, Percy H, Pitts, William J, Xie, Jenny, Dyckman, Alaric J

“…Sphingosine 1-phosphate (S1P) is the endogenous ligand for the sphingosine 1-phosphate receptors (S1P1–5) and evokes a variety of cellular responses through…”
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B cells from African American lupus patients exhibit an activated phenotype by Menard, Laurence C, Habte, Sium, Gonsiorek, Waldemar, Lee, Deborah, Banas, Dana, Holloway, Deborah A, Manjarrez-Orduno, Nataly, Cunningham, Mark, Stetsko, Dawn, Casano, Francesca, Kansal, Selena, Davis, Patricia M, Carman, Julie, Zhang, Clarence K, Abidi, Ferva, Furie, Richard, Nadler, Steven G, Suchard, Suzanne J

“…Systemic lupus erythematosus (SLE) is a complex systemic autoimmune disease driven by both innate and adaptive immune cells. African Americans tend to present…”
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Abatacept modulates human dendritic cell-stimulated T-cell proliferation and effector function independent of IDO induction by Davis, Patricia M, Nadler, Steven G, Stetsko, Dawn K, Suchard, Suzanne J

“…Abstract Abatacept, the first in a new class of agents for RA, modulates CD28-mediated T-cell costimulation. Abatacept was evaluated for its ability to…”
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An LFA-1 ({alpha}L{beta}2) Small-Molecule Antagonist Reduces Inflammation and Joint Destruction in Murine Models of Arthritis by Suchard, Suzanne J, Stetsko, Dawn K, Davis, Patricia M, Skala, Stacey, Potin, Dominique, Launay, Michele, Dhar, T. G. Murali, Barrish, Joel C, Susulic, Vojkan, Shuster, David J, McIntyre, Kim W, McKinnon, Murray, Salter-Cid, Luisa

“…LFA-1 appears to play a central role in normal immune responses to foreign Ags. In autoimmune or inflammatory diseases, there is increased expression of LFA-1…”
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Identification and synthesis of potent and selective pyridyl-isoxazole based agonists of sphingosine-1-phosphate 1 (S1P1) by Guo, Junqing, Watterson, Scott H., Spergel, Steven H., Kempson, James, Langevine, Charles M., Shen, Ding Ren, Yarde, Melissa, Cvijic, Mary Ellen, Banas, Dana, Liu, Richard, Suchard, Suzanne J., Gillooly, Kathleen, Taylor, Tracy, Rex-Rabe, Sandra, Shuster, David J., McIntyre, Kim W., Cornelius, Georgia, D’Arienzo, Celia, Marino, Anthony, Balimane, Praveen, Salter-Cid, Luisa, McKinnon, Murray, Barrish, Joel C., Carter, Percy H., Pitts, William J., Xie, Jenny, Dyckman, Alaric J.

“…[Display omitted] The synthesis and structure–activity relationship (SAR) of a series of pyridyl-isoxazole based agonists of S1P1 are discussed. Compound 5b…”
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Small Molecule Antagonist of Leukocyte Function Associated Antigen-1 (LFA-1): Structure−Activity Relationships Leading to the Identification of 6-((5S,9R)-9-(4-Cyanophenyl)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4.4]nonan-7-yl)nicotinic Acid (BMS-688521) by Watterson, Scott H, Xiao, Zili, Dodd, Dharmpal S, Tortolani, David R, Vaccaro, Wayne, Potin, Dominique, Launay, Michele, Stetsko, Dawn K, Skala, Stacey, Davis, Patric M, Lee, Deborah, Yang, Xiaoxia, McIntyre, Kim W, Balimane, Praveen, Patel, Karishma, Yang, Zheng, Marathe, Punit, Kadiyala, Pathanjali, Tebben, Andrew J, Sheriff, Steven, Chang, ChiehYing Y, Ziemba, Theresa, Zhang, Huiping, Chen, Bang-Chi, DelMonte, Albert J, Aranibar, Nelly, McKinnon, Murray, Barrish, Joel C, Suchard, Suzanne J, Murali Dhar, T. G

“…Leukocyte function-associated antigen-1 (LFA-1), also known as CD11a/CD18 or αLβ2, belongs to the β2 integrin subfamily and is constitutively expressed on all…”
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Abatacept Does Not Induce Direct Gene Expression Changes in Antigen-Presenting Cells by Carman, Julie A, Davis, Patricia M, Yang, Wen-Pin, Zhu, Jun, Chang, Han, He, Aiqing, Truong, Amy, Suchard, Suzanne J, Nadler, Steven G

“…Background It has been proposed that ligation of CD80 and CD86 induces reverse signaling into antigen-presenting cells. In this study, we tested the ability of…”
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Discovery and Development of 5-[(5S,9R)-9- (4-Cyanophenyl)-3-(3,5-dichlorophenyl)-1- methyl-2,4-dioxo-1,3,7-triazaspiro[4.4]non- 7-yl-methyl]-3-thiophenecarboxylic Acid (BMS-587101)A Small Molecule Antagonist of Leukocyte Function Associated Antigen-1 by Potin, Dominique, Launay, Michele, Monatlik, Francoise, Malabre, Patrice, Fabreguettes, Maud, Fouquet, Andre, Maillet, Magali, Nicolai, Eric, Dorgeret, Loïc, Chevallier, François, Besse, Dominique, Dufort, Monique, Caussade, François, Ahmad, Syed Z, Stetsko, Dawn K, Skala, Stacey, Davis, Patricia M, Balimane, Praveen, Patel, Karishma, Yang, Zheng, Marathe, Punit, Postelneck, Jennifer, Townsend, Robert M, Goldfarb, Valentina, Sheriff, Steven, Einspahr, Howard, Kish, Kevin, Malley, Mary F, DiMarco, John D, Gougoutas, Jack Z, Kadiyala, Pathanjali, Cheney, Daniel L, Tejwani, Ravindra W, Murphy, Denette K, Mcintyre, Kim W, Yang, Xiaoxia, Chao, Sam, Leith, Leslie, Xiao, Zili, Mathur, Arvind, Chen, Bang-Chi, Wu, Daugh-Rurng, Traeger, Sarah C, McKinnon, Murray, Barrish, Joel C, Robl, Jeffrey A, Iwanowicz, Edwin J, Suchard, Suzanne J, Dhar, T. G. Murali

“…LFA-1 (leukocyte function-associated antigen-1), is a member of the β2-integrin family and is expressed on all leukocytes. This letter describes the discovery…”
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Syk Activation Is Required for Spreading and H2O2 Release in Adherent Human Neutrophils by Fernandez, Rosemarie, Suchard, Suzanne J

“…Chemoattractant-stimulated polymorphonuclear leukocytes (PMNs) that are adherent to extracellular matrix proteins exhibit a massive, sustained respiratory…”
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Potent Reversible Inhibitors of the Protein Tyrosine Phosphatase CD45 by Urbanek, Rebecca A, Suchard, Suzanne J, Steelman, Gary B, Knappenberger, Katharine S, Sygowski, Linda A, Veale, Chris A, Chapdelaine, Marc J

“…The cytosolic portion of CD45, a major transmembrane glycoprotein found on nucleated hematopoietic cells, contains protein tyrosine phosphatase activity and is…”
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Design of LFA-1 antagonists based on a 2,3-dihydro-1H-pyrrolizin-5(7aH)-one scaffold by DODD, Dharmpal S, SHERIFF, Steven, MCKINNON, Murray, BARRISH, Joel C, SUCHARD, Suzanne J, MURALI DHAR, T. G, CHANGE, Chiehying J, STETSKO, Dawn K, PHILLIPS, Linda M, YINGRU ZHANG, LAUNAY, Michele, POTIN, Dominique, VACCARO, Wayne, POSS, Michael A

“…A new class of lymphocyte function-associated antigen-1 (LFA-1) antagonists is described. Elaboration of the 2,3-dihydro-1H-pyrrolizin-5(7aH)-one scaffold…”
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