Search Results - "Suchan, Martin"

Integrative analysis of structural variations using short-reads and linked-reads yields highly specific and sensitive predictions by Sethi, Riccha, Becker, Julia, Graaf, Jos de, Löwer, Martin, Suchan, Martin, Sahin, Ugur, Weber, David

“…Genetic diseases are driven by aberrations of the human genome. Identification of such aberrations including structural variations (SVs) is key to our…”
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Trans-amplifying RNA expressing functional miRNA mediates target gene suppression and simultaneous transgene expression by Yıldız, Ayşegül, Hasani, Aida, Hempel, Tina, Köhl, Nina, Beicht, Aline, Becker, René, Hubich-Rau, Stefanie, Suchan, Martin, Poleganov, Marco A., Sahin, Ugur, Beissert, Tim

“…The co-delivery of microRNAs (miRNAs) and protein-coding RNA presents an opportunity for a combined approach to gene expression and gene regulation for…”
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A non-functional neoepitope specific CD8+ T-cell response induced by tumor derived antigen exposure in vivo by Vormehr, Mathias, Reinhard, Katharina, Blatnik, Renata, Josef, Kathrin, Beck, Jan David, Salomon, Nadja, Suchan, Martin, Selmi, Abderraouf, Vascotto, Fulvia, Zerweck, Johannes, Wenschuh, Holger, Diken, Mustafa, Kreiter, Sebastian, Türeci, Özlem, Riemer, Angelika B., Sahin, Ugur

“…Cancer-associated mutations, mostly single nucleotide variations, can act as neoepitopes and prime targets for effective anti-cancer T-cell immunity. T cells…”
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Characterization of BV6-Induced Sensitization to the NK Cell Killing of Pediatric Rhabdomyosarcoma Spheroids by Särchen, Vinzenz, Reindl, Lisa Marie, Wiedemann, Sara, Shanmugalingam, Senthan, Bukur, Thomas, Becker, Julia, Suchan, Martin, Ullrich, Evelyn, Vogler, Meike

“…Although the overall survival in pediatric rhabdomyosarcoma (RMS) has increased over the last decades, the most aggressive subtype of alveolar RMS is in dire…”
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An RNA vaccine drives expansion and efficacy of claudin-CAR-T cells against solid tumors by Reinhard, Katharina, Rengstl, Benjamin, Oehm, Petra, Michel, Kristina, Billmeier, Arne, Hayduk, Nina, Klein, Oliver, Kuna, Kathrin, Ouchan, Yasmina, Wöll, Stefan, Christ, Elmar, Weber, David, Suchan, Martin, Bukur, Thomas, Birtel, Matthias, Jahndel, Veronika, Mroz, Karolina, Hobohm, Kathleen, Kranz, Lena, Diken, Mustafa, Kühlcke, Klaus, Türeci, Özlem, Sahin, Ugur

“…Chimeric antigen receptor (CAR)-T cells have shown efficacy in patients with B cell malignancies. Yet, their application for solid tumors has challenges that…”
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Personalized RNA mutanome vaccines mobilize poly-specific therapeutic immunity against cancer by Sahin, Ugur, Derhovanessian, Evelyna, Miller, Matthias, Kloke, Björn-Philipp, Simon, Petra, Löwer, Martin, Bukur, Valesca, Tadmor, Arbel D., Luxemburger, Ulrich, Schrörs, Barbara, Omokoko, Tana, Vormehr, Mathias, Albrecht, Christian, Paruzynski, Anna, Kuhn, Andreas N., Buck, Janina, Heesch, Sandra, Schreeb, Katharina H., Müller, Felicitas, Ortseifer, Inga, Vogler, Isabel, Godehardt, Eva, Attig, Sebastian, Rae, Richard, Breitkreuz, Andrea, Tolliver, Claudia, Suchan, Martin, Martic, Goran, Hohberger, Alexander, Sorn, Patrick, Diekmann, Jan, Ciesla, Janko, Waksmann, Olga, Brück, Alexandra-Kemmer, Witt, Meike, Zillgen, Martina, Rothermel, Andree, Kasemann, Barbara, Langer, David, Bolte, Stefanie, Diken, Mustafa, Kreiter, Sebastian, Nemecek, Romina, Gebhardt, Christoffer, Grabbe, Stephan, Höller, Christoph, Utikal, Jochen, Huber, Christoph, Loquai, Carmen, Türeci, Özlem

“…The authors report the first-in-human application of personalized neo-antigen RNA vaccines in patients with melanoma. Personalized cancer vaccine trials…”
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Long-lasting mRNA-encoded interleukin-2 restores CD8 + T cell neoantigen immunity in MHC class I-deficient cancers by Beck, Jan D, Diken, Mustafa, Suchan, Martin, Streuber, Michael, Diken, Elif, Kolb, Laura, Allnoch, Lisa, Vascotto, Fulvia, Peters, Daniel, Beißert, Tim, Akilli-Öztürk, Özlem, Türeci, Özlem, Kreiter, Sebastian, Vormehr, Mathias, Sahin, Ugur

“…Major histocompatibility complex (MHC) class I antigen presentation deficiency is a common cancer immune escape mechanism, but the mechanistic implications and…”
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Accurate detection of tumor-specific gene fusions reveals strongly immunogenic personal neo-antigens by Weber, David, Ibn-Salem, Jonas, Sorn, Patrick, Suchan, Martin, Holtsträter, Christoph, Lahrmann, Urs, Vogler, Isabel, Schmoldt, Kathrin, Lang, Franziska, Schrörs, Barbara, Löwer, Martin, Sahin, Ugur

“…Cancer-associated gene fusions are a potential source for highly immunogenic neoantigens, but the lack of computational tools for accurate, sensitive…”
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Advantages of endoscopic transsphenoidal pituitary gland tumor surgery by Suchan, Martin, Kaliarik, Laddislav, Zeliznak, Vladimir, Skalova, Maria, Kollova, Aurelia, Banocy, Jan

“…OBJECTIVEThe aim of the study was to hihglight the benefits and safety of the endoscopic transsphenoidal pituitary gland tumor surgery.BACKGROUNDThe endoscopic…”
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Prediction of tumor-specific splicing from somatic mutations as a source of neoantigen candidates by Lang, Franziska, Sorn, Patrick, Suchan, Martin, Henrich, Alina, Albrecht, Christian, Köhl, Nina, Beicht, Aline, Riesgo-Ferreiro, Pablo, Holtsträter, Christoph, Schrörs, Barbara, Weber, David, Löwer, Martin, Sahin, Ugur, Ibn-Salem, Jonas

“…Abstract Motivation Neoantigens are promising targets for cancer immunotherapies and might arise from alternative splicing. However, detecting tumor-specific…”
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A TCR-like CAR Promotes Sensitive Antigen Recognition and Controlled T-cell Expansion Upon mRNA Vaccination by Birtel, Matthias, Voss, Ralf-Holger, Reinhard, Katharina, Rengstl, Benjamin, Ouchan, Yasmina, Michel, Kristina, Hayduk, Nina, Tillmann, Bodo, Becker, René, Suchan, Martin, Theobald, Matthias, Oehm, Petra, Türeci, Özlem, Sahin, Ugur

“…Chimeric antigen receptor (CAR) T cells are efficacious in patients with B-cell malignancies, while their activity is limited in patients with solid tumors. We…”
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