Search Results - "Suchý, Mojmír"

A Remarkably Simple Protocol for the N-Formylation of Amino Acid Esters and Primary Amines by Suchý, Mojmír, Elmehriki, Adam A. H, Hudson, Robert H. E

“…A simple, convenient, and wide scope protocol for the N-formylation of amino acid esters and primary amines has been developed utilizing only imidazole in warm…”
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Direct mapping of kidney function by DCE-MRI urography using a tetrazinanone organic radical contrast agent by Calvert, Nicholas D., Kirby, Alexia, Suchý, Mojmír, Pallister, Peter, Torrens, Aidan A., Burger, Dylan, Melkus, Gerd, Schieda, Nicola, Shuhendler, Adam J.

“…Chronic kidney disease (CKD) and acute kidney injury (AKI) are ongoing global health burdens. Glomerular filtration rate (GFR) is the gold standard measure of…”
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Simultaneous in vivo pH and temperature mapping using a PARACEST-MRI contrast agent by McVicar, Nevin, Li, Alex X., Suchý, Mojmír, Hudson, Robert H. E., Menon, Ravi S., Bartha, Robert

“…Altered tissue temperature and/or pH is a common feature in pathological conditions, where metabolic demand exceeds oxygen supply such as in tumors and…”
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Tracking the fate of bacteria-derived site-specific immunomodulators by positron emission tomography by Kirby, Alexia, Suchý, Mojmír, Duan, Daniel, Bazett, Mark, Kalyan, Shirin, Shuhendler, Adam J.

“…Site-specific immunomodulators (SSIs) are a novel class of therapeutics made from inactivated bacterial species designed to regulate the innate immune system…”
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Mapping vitamin B 6 metabolism by hydrazoCEST magnetic resonance imaging by Brun, Emilie Marie Sophie Patit-Tha, Calvert, Nicholas David, Suchý, Mojmír, Kirby, Alexia, Melkus, Gerd, Garipov, Ruslan, Addison, Christina L, Shuhendler, Adam J

“…A new CEST-MRI contrast agent, 2-HYNIC, capable of sensing aromatic aldehydes is reported. Pyridoxal 5'-phosphate, a key Vitamin B metabolite necessary for…”
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MRI Probes for In Vivo Aldehyde Sensing by Kirby, Alexia, Suchý, Mojmír, Shuhendler, Adam J.

“…Endogenous aldehydes are produced via tightly regulated metabolic processes and are rapidly cleared by aldehyde dehydrogenases. However, dysregulation of these…”
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Pyrimidine-Fused Heterocyclic Frameworks Based on an N4-Arylcytosine Scaffold: Synthesis, Characterization, and PNA Oligomerization of the Fluorescent Cytosine Analogue 5,6-BenzopC by Suchý, Mojmír, Hudson, Robert H. E

“…A synthesis of an intrinsically fluorescent cytosine analogue 5,6-benzopC has been developed utilizing the reductive Ni-mediated cyclization of an…”
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Unusual C7- versus Normal 5′-O-Dimethoxytritylation of 6‑Arylpyrrolocytidine Analogs by Suchý, Mojmír, Ettles, Christie, Wisner, James A, Matarazzo, Augusto, Hudson, Robert H. E

“…Fluorescent deoxynucleosides possessing the modified bases 6-(2-benzo­[b]­furyl)- and 6-(2-furyl)­pyrrolocytosine (BFpC and FpC) have been synthesized along…”
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Fingerprinting Biogenic Aldehydes through Pattern Recognition Analyses of Excitation–Emission Matrices by Lazurko, Caitlin, Radonjic, Ivana, Suchý, Mojmír, Liu, George, Rolland‐Lagan, Anne‐Gaëlle, Shuhendler, Adam

“…Biogenic carbonyls, especially aldehydes, have previously demonstrated their potential to serve as early diagnostic biomarkers for disease and injury that have…”
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Introduction of Peripheral Carboxylates to Decrease the Charge on Tm3+ DOTAM-Alkyl Complexes: Implications for Detection Sensitivity and in Vivo Toxicity of PARACEST MRI Contrast Agents by Suchý, Mojmír, Milne, Mark, Elmehriki, Adam A. H, McVicar, Nevin, Li, Alex X, Bartha, Robert, Hudson, Robert H. E

“…A series of structurally modified Tm3+ DOTAM-alkyl complexes as potential PARACEST MRI contrast agents has been synthesized with the aim to decrease the…”
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Preliminary evaluation of PARACEST MRI agents for the detection of nitric oxide synthase by Suchý, Mojmír, Li, Alex X, Liu, Yin, Feng, Qingping, Bartha, Robert, Hudson, Robert H.E

“…Several paramagnetic chemical exchange saturation transfer magnetic resonance imaging (PARACEST MRI) agents for the potential detection of nitric oxide…”
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A paramagnetic chemical exchange-based MRI probe metabolized by cathepsin D: design, synthesis and cellular uptake studies by Suchý, Mojmír, Ta, Robert, Li, Alex X, Wojciechowski, Filip, Pasternak, Stephen H, Bartha, Robert, Hudson, Robert H E

“…Overexpression of the aspartyl protease cathepsin D is associated with certain cancers and Alzheimer's disease; thus, it is a potentially useful imaging…”
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A bifunctional chelator featuring the DOTAM-Gly- l-Phe-OH structural subunit: en route toward homo- and heterobimetallic lanthanide(III) complexes as PARACEST MRI contrast agents by Suchý, Mojmír, Li, Alex X., Bartha, Robert, Hudson, Robert H.E.

“…A new synthesis of a bifunctional chelator possessing DOTAM-Gly- l-Phe-OH and DO3A chelating cages interconnected by an oligoamide chain has been achieved via…”
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DOTAM-type ligands possessing arginine pendant groups for use in PARACEST MRI by Suchý, Mojmír, Li, Alex X, Milne, Mark, Bartha, Robert, Hudson, Robert H E

“…A synthetic methodology was developed for the preparation of metal-chelating ligands that possess arginine pendant groups relying on the alkylation of…”
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In vivo detection of PARACEST agents with relaxation correction by Jones, Craig K., Li, Alex X., Suchý, Mojmír, Hudson, Robert H. E., Menon, Ravi S., Bartha, Robert

“…Several pulse sequences have been used to detect paramagnetic chemical exchange saturation transfer (PARACEST) contrast agents in animals to quantify the…”
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Synthesis, Absolute Configuration, and Enantiomeric Enrichment of a Cruciferous Oxindole Phytoalexin, (S)-(−)-Spirobrassinin, and Its Oxazoline Analog by Suchý, Mojmír, Kutschy, Peter, Monde, Kenji, Goto, Hitoshi, Harada, Nobuyuki, Takasugi, Mitsuo, Dzurilla, Milan, Balentová, Eva

“…Stereochemical studies of a cruciferous oxindole phytoalexin, (S)-(−)-spirobrassinin [(−)-4], and its oxazoline analogue, spirooxazoline (11), were carried…”
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Complexes of selected late period lanthanide(III) cations with 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid amide (DOTAM)-alkyl ligands — A new platform for the development of paramagnetic chemical exchange saturation transfer (PARACEST) magnetic resonance imaging (MRI) contrast agents by Elmehriki, Adam A.H., Milne, Mark, Suchý, Mojmír, Bartha, Robert, Hudson, Robert H.E.

“…A series of 18 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid amide (DOTAM)-alkyl derived complexes with selected late lanthanide(III) cations (Dy 3+…”
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A new synthesis of cystamine modified Eu3+ DOTAM-Gly-Phe-OH: a conjugation ready temperature sensitive MRI contrast agent by Suchý, Mojmír, Li, Alex X, Bartha, Robert, Hudson, Robert H E

“…Several approaches towards asymmetrically derivatized peptide-decorated cyclens that yield lanthanide metal chelators, in which three of the nitrogen atoms of…”
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Spirocyclization strategy toward indole phytoalexins. The first synthesis of (±)-1-methoxyspirobrassinin, (±)-1-methoxyspirobrassinol, and (±)-1-methoxyspirobrassinol methyl ether by Kutschy, Peter, Suchý, Mojmı́r, Monde, Kenji, Harada, Nobuyuki, Marušková, Renata, Čurillová, Zuzana, Dzurilla, Milan, Miklošová, Mariana, Mezencev, Roman, Mojžiš, Ján

“…The first syntheses of cruciferous indole phytoalexins (±)-1-methoxyspirobrassinin, (±)-1-methoxyspirobrassinol, (±)-1-methoxyspirobrassinol methyl ether as…”
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Synthesis of MRI contrast agents derived from DOTAM-Gly- l-Phe-OH incorporating a disulfide bridge: Conjugation to a cell penetrating peptide and preparation of a dimeric agent by Suchý, Mojmír, Li, Alex X., Bartha, Robert, Hudson, Robert H.E.

“…Synthesis and characterization of disulfide-bridged cell penetrating peptide conjugated and dimeric PARACEST MRI contrast agents based on DOTAM-Gly- l-Phe-OH…”
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