Search Results - "Subramanyam, Prakash"

Structural mechanism of ligand activation in human calcium-sensing receptor by Geng, Yong, Mosyak, Lidia, Kurinov, Igor, Zuo, Hao, Sturchler, Emmanuel, Cheng, Tat Cheung, Subramanyam, Prakash, Brown, Alice P, Brennan, Sarah C, Mun, Hee-Chang, Bush, Martin, Chen, Yan, Nguyen, Trang X, Cao, Baohua, Chang, Donald D, Quick, Matthias, Conigrave, Arthur D, Colecraft, Henry M, McDonald, Patricia, Fan, Qing R

“…Human calcium-sensing receptor (CaSR) is a G-protein-coupled receptor (GPCR) that maintains extracellular Ca(2+) homeostasis through the regulation of…”
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Serotonin-reuptake inhibitors act centrally to cause bone loss in mice by counteracting a local anti-resorptive effect by Ortuño, María José, Robinson, Samuel T, Subramanyam, Prakash, Paone, Riccardo, Huang, Yung-yu, Guo, X Edward, Colecraft, Henry M, Mann, J John, Ducy, Patricia

“…Long-term use of serotonin-reuptake inhibitors causes bone loss by acting centrally to counteract a peripheral, beneficial effect on bone. The use of selective…”
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Inhibition of NAPDH Oxidase 2 (NOX2) Prevents Oxidative Stress and Mitochondrial Abnormalities Caused by Saturated Fat in Cardiomyocytes by Joseph, Leroy C, Barca, Emanuele, Subramanyam, Prakash, Komrowski, Michael, Pajvani, Utpal, Colecraft, Henry M, Hirano, Michio, Morrow, John P

“…Obesity and high saturated fat intake increase the risk of heart failure and arrhythmias. The molecular mechanisms are poorly understood. We hypothesized that…”
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Mitochondrial oxidative stress during cardiac lipid overload causes intracellular calcium leak and arrhythmia by Joseph, Leroy C., PhD, Subramanyam, Prakash, PhD, Radlicz, Christopher, BS, Trent, Chad M., PhD, Iyer, Vivek, MD, MSE, Colecraft, Henry M., PhD, Morrow, John P., MD, FHRS

“…Background Diabetes and obesity are associated with an increased risk of arrhythmia and sudden cardiac death. Abnormal lipid accumulation is observed in…”
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Extended exposure to low doses of azacitidine induces differentiation of leukemic stem cells through activation of myeloperoxidase by Jeyaraju, Danny V, Alapa, Maryam, Polonskaia, Ann, Risueño, Alberto, Subramanyam, Prakash, Anand, Amit, Ghosh, Kaushik, Kyriakopoulos, Charalampos, Hemerich, Daiane, Hurren, Rose, Wang, Xiaoming, Gronda, Marcela, Ahsan, Aarif, Chiu, Hsiling, Thomas, Geethu, Lind, Evan F, Menezes, Daniel L, Schimmer, Aaron D, Hagner, Patrick R, Gandhi, Anita, Thakurta, Anjan G

“…Oral azacitidine (oral-Aza) treatment results in longer median overall survival (OS) (24.7 vs. 14.8 months in placebo) in patients with acute myeloid leukemia…”
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LQT1 mutations in KCNQ1 C-terminus assembly domain suppress IKs using different mechanisms by Aromolaran, Ademuyiwa S, Subramanyam, Prakash, Chang, Donald D, Kobertz, William R, Colecraft, Henry M

“…Long QT syndrome 1 (LQT1) mutations in KCNQ1 that decrease cardiac IKs (slowly activating delayed rectifier K(+) current) underlie ventricular arrhythmias and…”
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Inhibition of NADPH oxidase 2 (NOX2) prevents sepsis-induced cardiomyopathy by improving calcium handling and mitochondrial function by Joseph, Leroy C, Kokkinaki, Dimitra, Valenti, Mesele-Christina, Kim, Grace J, Barca, Emanuele, Tomar, Dhanendra, Hoffman, Nicholas E, Subramanyam, Prakash, Colecraft, Henry M, Hirano, Michio, Ratner, Adam J, Madesh, Muniswamy, Drosatos, Konstantinos, Morrow, John P

“…Cardiomyopathy frequently complicates sepsis and is associated with increased mortality. Increased cardiac oxidative stress and mitochondrial dysfunction have…”
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Manipulating L-type calcium channels in cardiomyocytes using split-intein protein transsplicing by Subramanyam, Prakash, Chang, Donald D., Fang, Kun, Xie, Wenjun, Marks, Andrew R., Colecraft, Henry M.

“…Manipulating expression of large genes (>6 kb) in adult cardiomyocytes is challenging because these cells are only efficiently transduced by viral vectors with…”
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Correction: Inhibition of NAPDH Oxidase 2 (NOX2) Prevents Oxidative Stress and Mitochondrial Abnormalities Caused by Saturated Fat in Cardiomyocytes by Joseph, Leroy C, Barca, Emanuele, Subramanyam, Prakash, Komrowski, Michael, Pajvani, Utpal, Colecraft, Henry M, Hirano, Michio, Morrow, John P

“…[This corrects the article DOI: 10.1371/journal.pone.0145750.]…”
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Ion Channel Engineering: Perspectives and Strategies by Subramanyam, Prakash, Colecraft, Henry M.

“…Ion channels facilitate the passive movement of ions down an electrochemical gradient and across lipid bilayers in cells. This phenomenon is essential for life…”
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Activity and calcium regulate nuclear targeting of the calcium channel beta4b subunit in nerve and muscle cells by Subramanyam, Prakash, Obermair, Gerald J., Baumgartner, Sabine, Gebhart, Mathias, Striessnig, Jörg, Kaufmann, Walter A., Geley, Stephan, Flucher, Bernhard E.

“…Auxiliary beta subunits are critical determinants of membrane expression and gating properties of voltage-gated calcium channels. Mutations in the beta4…”
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Cardiac CaV1.2 channels require β subunits for β-adrenergic-mediated modulation but not trafficking by Yang, Lin, Katchman, Alexander, Kushner, Jared, Kushnir, Alexander, Zakharov, Sergey I, Chen, Bi-Xing, Shuja, Zunaira, Subramanyam, Prakash, Liu, Guoxia, Papa, Arianne, Roybal, Daniel, Pitt, Geoffrey S, Colecraft, Henry M, Marx, Steven O

“…Ca2+ channel β-subunit interactions with pore-forming α-subunits are long-thought to be obligatory for channel trafficking to the cell surface and for tuning…”
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Low Exposure Extended Dosing Mimicking Clinical Exposures of the Oral Formulation of Azacitidine Results in a Sustained Hypomethylation and Targets Leukemic Stem Cells by Jeyaraju, Danny V, Alapa, Maryam, Polonskaia, Ann, Risueño, Alberto, Ahsan, Aarif, Wang, Chao, Subramanyam, Prakash, Sriganesh, Jammula, Anand, Amit, Jain, Gaurav, Reddy, Madhusudhan, Ghosh, Kaushik, Kyriakopoulos, Charalampos, Lailler, Nathalie, Hartl, Christopher, Lopes de Menezes, Daniel, Hagner, Patrick, Thakurta, Anjan

“…Acute Myeloid Leukemia (AML) is characterized by uncontrolled proliferation of incompletely differentiated myeloid stem/ progenitor cells. Despite recent…”
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N-terminal variant Asp14Asn of the human p70 S6 Kinase 1 enhances translational signaling causing different effects in developing and mature neuronal cells by Venkatasubramani, Janani Priya, Subramanyam, Prakash, Pal, Rakhi, Reddy, Bharath K., Srinivasan, Durga Jeyalakshmi, Chattarji, Sumantra, Iossifov, Ivan, Klann, Eric, Bhattacharya, Aditi

“…•Asp14Asn (D14N) is a commonly found variant of human p70 ribosomal S6 Kinase.•D14N increases basal translation and downstream signaling.•D14N expression…”
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Dual Role of Functionally Intact Dyadic Junctions in Cardiac Excitation-Contraction Coupling by Subramanyam, Prakash, Chang, Donald D., Colecraft, Henry M.

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Correction: Inhibition of NAPDH Oxidase 2 by Joseph, Leroy C, Barca, Emanuele, Subramanyam, Prakash, Komrowski, Michael, Pajvani, Utpal, Colecraft, Henry M, Hirano, Michio, Morrow, John P

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Dissecting Roles of Cav1.2 (α1C) Intracellular Loops in Cardiac Excitation-Contraction Coupling by Subramanyam, Prakash, Chang, Donald D., Colecraft, Henry M.

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Dietary Saturated Fat Promotes Arrhythmia by Activating NOX2 (NADPH Oxidase 2) by Joseph, Leroy C, Avula, Uma Mahesh R, Wan, Elaine Y, Reyes, Michael V, Lakkadi, Kundanika R, Subramanyam, Prakash, Nakanishi, Koki, Homma, Shunichi, Muchir, Antoine, Pajvani, Utpal B, Thorp, Edward B, Reiken, Steven R, Marks, Andrew R, Colecraft, Henry M, Morrow, John P

“…BACKGROUND:Obesity and diets high in saturated fat increase the risk of arrhythmias and sudden cardiac death. However, the molecular mechanisms are not well…”
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Cardiac [Ca.sub.V]1.2 channels require [beta] subunits for [beta]-adrenergic-mediated modulation but not trafficking by Yang, Lin, Katchman, Alexander, Kushner, Jared, Kushnir, Alexander, Zakharov, Sergey I, Chen, Bi-xing, Shuja, Zunaira, Subramanyam, Prakash, Liu, Guoxia, Papa, Arianne, Roybal, Daniel, Pitt, Geoffrey S, Colecraft, Henry M, Marx, Steven O

“…[Ca.sup.2+] channel [beta]-subunit interactions with pore-forming [alpha]-subunits are long-thought to be obligatory for channel trafficking to the cell…”
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Reciprocal Interactions Regulate Targeting of Calcium Channel β Subunits and Membrane Expression of α1 Subunits in Cultured Hippocampal Neurons by Obermair, Gerald J., Schlick, Bettina, Di Biase, Valentina, Subramanyam, Prakash, Gebhart, Mathias, Baumgartner, Sabine, Flucher, Bernhard E.

“…Auxiliary β subunits modulate current properties and mediate the functional membrane expression of voltage-gated Ca2+ channels in heterologous cells. In brain,…”
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