Search Results - "Subramanian, Madhan"

Sympathetic nervous system as a target for aging and obesity-related cardiovascular diseases by Balasubramanian, Priya, Hall, Delton, Subramanian, Madhan

“…Chronic sympathetic nervous system overactivity is a hallmark of aging and obesity and contributes to the development of cardiovascular diseases including…”
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Examination of neuro-inflammation and senescence in brainstem of aged mice latently infected with human alphaherpesvirus 1 (HSV-1) by Monteiro, Raisa, Kumar Sivasubramanian, Mahesh, Harrison, Kelly S., Plakkot, Bhuvana, Sadeghi, Hafez, Subramanian, Madhan, Jones, Clinton

“…•HSV-1 latently infected mice exhibit enhanced neuroinflammation in brainstem.•Principal sensory nucleus of spinal trigeminal tract (Pr5) of brainstem was…”
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Palmitic Acid Induces Oxidative Stress and Senescence in Human Brainstem Astrocytes, Downregulating Glutamate Reuptake Transporters-Implications for Obesity-Related Sympathoexcitation by Sivasubramanian, Mahesh Kumar, Monteiro, Raisa, Jagadeesh, Manoj, Balasubramanian, Priya, Subramanian, Madhan

“…Obesity has been associated with a chronic increase in sympathetic nerve activity, which can lead to hypertension and other cardiovascular diseases…”
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Implications of Hypothalamic Neural Stem Cells on Aging and Obesity-Associated Cardiovascular Diseases by Plakkot, Bhuvana, Di Agostino, Ashley, Subramanian, Madhan

“…The hypothalamus, one of the major regulatory centers in the brain, controls various homeostatic processes, and hypothalamic neural stem cells (htNSCs) have…”
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Functional role of vitronectin in breast cancer by Bera, Alakesh, Subramanian, Madhan, Karaian, John, Eklund, Michael, Radhakrishnan, Surya, Gana, Nahbuma, Rothwell, Stephen, Pollard, Harvey, Hu, Hai, Shriver, Craig D, Srivastava, Meera

“…Breast Cancer is the most common form of cancer in women worldwide, impacting nearly 2.1 million women each year. Identification of new biomarkers could be key…”
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Obesity as a premature aging phenotype — implications for sarcopenic obesity by Nunan, Emily, Wright, Carson L., Semola, Oluwayemisi A., Subramanian, Madhan, Balasubramanian, Priya, Lovern, Pamela C., Fancher, Ibra S., Butcher, Joshua T.

“…Obesity and aging have both seen dramatic increases in prevalence throughout society. This review seeks to highlight common pathologies that present with…”
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Altered Differential Control of Sympathetic Outflow Following Sedentary Conditions: Role of Subregional Neuroplasticity in the RVLM by Subramanian, Madhan, Mueller, Patrick J

“…Despite the classically held belief of an "all-or-none" activation of the sympathetic nervous system, differential responses in sympathetic nerve activity…”
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(In)activity-related neuroplasticity in brainstem control of sympathetic outflow: unraveling underlying molecular, cellular, and anatomical mechanisms by Mischel, Nicholas A, Subramanian, Madhan, Dombrowski, Maryetta D, Llewellyn-Smith, Ida J, Mueller, Patrick J

“…More people die as a result of physical inactivity than any other preventable risk factor including smoking, high cholesterol, and obesity. Cardiovascular…”
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Chronic exposure to low doses of estradiol-17ß increases blood pressure in young female rats: A possible role for central Endothelin-1 by Subramanian, Madhan, MohanKumar, Sheba M. J., Balasubramanian, Priya, Northcott, Carrie A., Garver, Hannah, Fink, Gregory D., MohanKumar, P. S.

“…Previously, we demonstrated that chronic exposure to low levels of estradiol-17β (E2) increases mean arterial pressure (MAP) in young female Sprague-Dawley…”
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Chronic estradiol exposure induces oxidative stress in the hypothalamus to decrease hypothalamic dopamine and cause hyperprolactinemia by MohanKumar, Sheba M J, Kasturi, Badrinarayanan S, Shin, Andrew C, Balasubramanian, Priya, Gilbreath, Ebony T, Subramanian, Madhan, Mohankumar, Puliyur S

“…Estrogens are known to cause hyperprolactinemia, most probably by acting on the tuberoinfundibular dopaminergic (TIDA) system of the hypothalamus. Dopamine…”
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Evaluation of Hypothalamic Neural Stem Cell Niche – Implications on Obesity‐Induced Sympathoexcitation by Plakkot, Bhuvana, Subramanian, Madhan

“…The newly discovered hypothalamic neural stem cell niche is emerging as a key player in the regulation of systemic homeostasis. Previous studies have shown…”
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Abstract P162: Senolytic Treatment Attenuates Palmitic Acid-Induced Microglial Activation: Therapeutic Implications for Obesity-Induced Sympathoexcitation by Plakkot, Bhuvana, Turtle, Chenoa, Subramanian, Madhan

“…Abstract only Objective: Microglial dysfunction has been previously implicated in the pathogenesis of obesity-induced neuroinflammation and sympathoexcitation,…”
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Thermogenic stimulation improves systemic metabolism and healthspan outcomes in aged mice by Balasubramanian, Priya, Subramanian, Madhan, Plakkot, Bhuvana

“…Abstract only Adipose tissue metabolism plays a pivotal role in systemic aging by regulating whole-body energy and glucose metabolism. Emerging evidence links…”
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Dysfunctional Nrf2‐Keap1 redox signaling in the RVLM is linked to obesity‐induced sympathoexcitation by Monteiro, Raisa, Sivasubramanian, Mahesh Kumar, Balasubramanian, Priya, Subramanian, Madhan

“…The rostral ventrolateral medulla (RVLM) is an important region in the brainstem responsible for the tonic and reflex control of sympathetic nerve activity…”
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Elimination of Senescent Cells Attenuates Obesity‐Induced Increase in Sympathetic Nerve Activity by Sivasubramanian, Mahesh Kumar, Monteiro, Raisa, Balasubramanian, Priya, Subramanian, Madhan

“…Obesity is a major risk factor for the development of cardiovascular diseases like hypertension. It is estimated that obesity accounts for approximately 65‐78%…”
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Selective Nrf2 Overexpression in the RVLM ameliorates Obesity-induced Sympathoexcitation by Monteiro, Raisa, Sivasubramanian, Mahesh Kumar, Balasubramanian, Priya, Subramanian, Madhan

“…Abstract only The rostral part of the ventrolateral medulla (RVLM) in the brainstem is an important region responsible for both the resting levels and the…”
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Microglia Senescence Mediates Inflammation in the Hypothalamus of High-Fat Diet Induced Obese Mice by Plakkot, Bhuvana, Di Agostino, Ashley, Balasubramanian, Priya, Subramanian, Madhan

“…Abstract only Hypothalamus is a major regulatory center in the brain responsible for various homeostasis processes. Distinct neurons and glial cells, including…”
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Palmitic acid induces Oxidative Stress, Senescence and Downregulates Glutamate Transporter Expression in Human Brainstem Astrocytes by Sivasubramanian, Mahesh Kumar, Monteiro, Raisa, Balasubramanian, Priya, Subramanian, Madhan

“…Abstract only Glial cells have emerged as critical players in sympathoexcitation and neurogenic hypertension in recent years. Glutamate reuptake transporters…”
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Abstract 135: Cellular Senescence in the Paraventricular Nucleus - Novel Implications for Obesity-Induced Sympathoexcitation by Subramanian, Madhan, Hall, Delton, Balasubramanian, Priya

“…Abstract only Oxidative stress in the paraventricular nucleus (PVN) of the hypothalamus has been implicated in the pathogenesis of obesity-induced…”
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Cellular Senescence in the Brainstem: Implications for Age‐Related Sympathetic Nervous System Dysregulation by Branen, Lyndee, Balasubramanian, Priya, Subramanian, Madhan

“…Aging is an independent risk factor for cardiovascular diseases such as hypertension and heart failure. Evidence from the literature suggests that sympathetic…”
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