Search Results - "Subramaniam, Prem"

Elucidating Compound Mechanism of Action by Network Perturbation Analysis by Woo, Jung Hoon, Shimoni, Yishai, Yang, Wan Seok, Subramaniam, Prem, Iyer, Archana, Nicoletti, Paola, Rodríguez Martínez, María, López, Gonzalo, Mattioli, Michela, Realubit, Ronald, Karan, Charles, Stockwell, Brent R., Bansal, Mukesh, Califano, Andrea

“…Genome-wide identification of the mechanism of action (MoA) of small-molecule compounds characterizing their targets, effectors, and activity modulators…”
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A modular master regulator landscape controls cancer transcriptional identity by Paull, Evan O., Aytes, Alvaro, Jones, Sunny J., Subramaniam, Prem S., Giorgi, Federico M., Douglass, Eugene F., Tagore, Somnath, Chu, Brennan, Vasciaveo, Alessandro, Zheng, Siyuan, Verhaak, Roel, Abate-Shen, Cory, Alvarez, Mariano J., Califano, Andrea

“…Despite considerable efforts, the mechanisms linking genomic alterations to the transcriptional identity of cancer cells remain elusive. Integrative genomic…”
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Network-based elucidation of colon cancer drug resistance mechanisms by phosphoproteomic time-series analysis by Rosenberger, George, Li, Wenxue, Turunen, Mikko, He, Jing, Subramaniam, Prem S., Pampou, Sergey, Griffin, Aaron T., Karan, Charles, Kerwin, Patrick, Murray, Diana, Honig, Barry, Liu, Yansheng, Califano, Andrea

“…Aberrant signaling pathway activity is a hallmark of tumorigenesis and progression, which has guided targeted inhibitor design for over 30 years. Yet, adaptive…”
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A precision oncology approach to the pharmacological targeting of mechanistic dependencies in neuroendocrine tumors by Alvarez, Mariano J., Subramaniam, Prem S., Tang, Laura H., Grunn, Adina, Aburi, Mahalaxmi, Rieckhof, Gabrielle, Komissarova, Elena V., Hagan, Elizabeth A., Bodei, Lisa, Clemons, Paul A., Dela Cruz, Filemon S., Dhall, Deepti, Diolaiti, Daniel, Fraker, Douglas A., Ghavami, Afshin, Kaemmerer, Daniel, Karan, Charles, Kidd, Mark, Kim, Kyoung M., Kim, Hee C., Kunju, Lakshmi P., Langel, Ülo, Li, Zhong, Lee, Jeeyun, Li, Hai, LiVolsi, Virginia, Pfragner, Roswitha, Rainey, Allison R., Realubit, Ronald B., Remotti, Helen, Regberg, Jakob, Roses, Robert, Rustgi, Anil, Sepulveda, Antonia R., Serra, Stefano, Shi, Chanjuan, Yuan, Xiaopu, Barberis, Massimo, Bergamaschi, Roberto, Chinnaiyan, Arul M., Detre, Tony, Ezzat, Shereen, Frilling, Andrea, Hommann, Merten, Jaeger, Dirk, Kim, Michelle K., Knudsen, Beatrice S., Kung, Andrew L., Leahy, Emer, Metz, David C., Milsom, Jeffrey W., Park, Young S., Reidy-Lagunes, Diane, Schreiber, Stuart, Washington, Kay, Wiedenmann, Bertram, Modlin, Irvin, Califano, Andrea

“…We introduce and validate a new precision oncology framework for the systematic prioritization of drugs targeting mechanistic tumor dependencies in individual…”
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Dclk1 Defines Quiescent Pancreatic Progenitors that Promote Injury-Induced Regeneration and Tumorigenesis by Westphalen, C. Benedikt, Takemoto, Yoshihiro, Tanaka, Takayuki, Macchini, Marina, Jiang, Zhengyu, Renz, Bernhard W., Chen, Xiaowei, Ormanns, Steffen, Nagar, Karan, Tailor, Yagnesh, May, Randal, Cho, Youngjin, Asfaha, Samuel, Worthley, Daniel L., Hayakawa, Yoku, Urbanska, Aleksandra M., Quante, Michael, Reichert, Maximilian, Broyde, Joshua, Subramaniam, Prem S., Remotti, Helen, Su, Gloria H., Rustgi, Anil K., Friedman, Richard A., Honig, Barry, Califano, Andrea, Houchen, Courtney W., Olive, Kenneth P., Wang, Timothy C.

“…The existence of adult pancreatic progenitor cells has been debated. While some favor the concept of facultative progenitors involved in homeostasis and…”
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Targeting Nonclassical Oncogenes for Therapy in T-ALL by Subramaniam, Prem S., Whye, Dosh W., Efimenko, Evgeni, Chen, Jianchung, Tosello, Valeria, De Keersmaecker, Kim, Kashishian, Adam, Thompson, Mary Ann, Castillo, Mireia, Cordon-Cardo, Carlos, Davé, Utpal P., Ferrando, Adolfo, Lannutti, Brian J., Diacovo, Thomas G.

“…Constitutive phosphoinositide 3-kinase (PI3K)/Akt activation is common in T cell acute lymphoblastic leukemia (T-ALL). Although four distinct class I PI3K…”
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A SOCS-1 peptide mimetic inhibits both constitutive and IL-6 induced activation of STAT3 in prostate cancer cells by FLOWERS, Lawrence O, SUBRAMANIAM, Prem S, JOHNSON, Howard M

“…Prostate cancer is the second highest cause of cancer-related deaths of men in the US. Signal transducers and activators of transcription (STATs) proteins are…”
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Trafficking and signaling pathways of nuclear localizing protein ligands and their receptors by Johnson, Howard M., Subramaniam, Prem S., Olsnes, Sjur, Jans, David A.

“…Interaction of ligands such as epidermal growth factor and interferon‐γ with the extracellular domains of their plasma membrane receptors results in…”
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Characterization of a Peptide Inhibitor of Janus Kinase 2 That Mimics Suppressor of Cytokine Signaling 1 Function by Flowers, Lawrence O, Johnson, Howard M, Mujtaba, Mustafa G, Ellis, Morgan R, Haider, S. Mohammed I, Subramaniam, Prem S

“…Positive and negative regulation of cytokines such as IFN-gamma are key to normal homeostatic function. Negative regulation of IFN-gamma in cells occurs via…”
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The IFNAR1 subunit of the type I IFN receptor complex contains a functional nuclear localization sequence by Subramaniam, Prem S., Johnson, Howard M.

“…A nuclear localization sequence (NLS) in the type II interferon (IFN) IFNγ, which is responsible for the nuclear translocation of both the ligand and the…”
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Peptide Mimetics of Gamma Interferon Possess Antiviral Properties against Vaccinia Virus and Other Viruses in the Presence of Poxvirus B8R Protein by AHMED, Chulbul M. I, BURKHART, Marjorie A, SUBRAMANIAM, Prem S, MUJTABA, Mustafa G, JOHNSON, Howard M

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Interferon γ is recognised by importin α/β: Enhanced nuclear localising and transactivation activities of an interferon γ mimetic by Fulcher, Alex J., Ahmed, Chulbul M.I., Noon-Song, Ezra N., Kwan, Rain Y.Q., Subramaniam, Prem S., Johnson, Howard M., Jans, David A.

“…Interferon (IFN) γ’s ability to localise in the nucleus and function in gene activation has been known for some time, although the role of the conventional…”
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Superantigen Enhancement of Specific Immunity: Antibody Production and Signaling Pathways by Torres, Barbara A, Perrin, George Q, Mujtaba, Mustafa G, Subramaniam, Prem S, Anderson, Amy K, Johnson, Howard M

“…Superantigens are microbial proteins that induce massive activation, proliferation, and cytokine production by CD4+ T cells via specific Vbeta elements on the…”
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Substrate Ambiguity of 3-Deoxy-d-manno-Octulosonate 8-Phosphate Synthase from Neisseria gonorrhoeae in the Context of Its Membership in a Protein Family Containing a Subset of 3-Deoxy-d-arabino-Heptulosonate 7-Phosphate Synthases by Subramaniam, P S, Xie, G, Xia, T, Jensen, R A

“…Article Usage Stats Services JB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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IFNα induces the expression of the cyclin-dependent kinase inhibitor p21 in human prostate cancer cells by HOBEIKA, A. C, SUBRAMANIAM, P. S, JOHNSON, H. M

“…Prostate cancer, like other types of cancer, is associated with the loss of cell cycle control, resulting in unregulated growth of cells. We report here on the…”
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Differential nuclear localization of the IFNGR-1 and IFNGR-2 subunits of the IFN-gamma receptor complex following activation by IFN-gamma by Larkin, 3rd, J, Johnson, H M, Subramaniam, P S

“…We have recently identified a nuclear localization sequence (NLS) in the C-terminus of murine type II interferon (IFN), IFN-gamma, that is responsible for the…”
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Crystal structure of ovine interferon-τ at 2.1 Å resolution by Radhakrishnan, Ramaswamy, Walter, Leigh J, Subramaniam, Prem S, Johnson, Howard M, Walter, Mark R

“…Ovine interferon-τ (ovIFN-τ) is a pregnancy recognition hormone required for normal embryonic development in sheep. In addition to its novel role in…”
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Differential Recognition of the Type I Interferon Receptor by Interferons τ and α is Responsible for Their Disparate Cytotoxicities by Subramaniam, P S, Khan, S A, Pontzer, C H, Johnson, H M

“…Interferon τ (IFNτ), originally identified as a pregnancy recognition hormone, is a type I interferon that is related to the various IFNα species (IFNαs)…”
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Signal Transduction Mechanism of A Peptide Mimetic of Interferon-γ by Subramaniam, Prem S, Flowers, Lawrence O, Haider, S. Mohammed I, Johnson, Howard M

“…The C-terminus of interferon-γ (IFNγ) contains a nuclear localization sequence (NLS) required for the activation and nuclear translocation of the transcription…”
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Abstract 1421: Targeting cell-adaptive mechanisms of drug resistance in lethal prostate cancer by Subramaniam, Prem, Vasciaveo, Alessandro, Arriaga, Juan, Kesner, Jordan, Abate-Shen, Cory, Califano, Andrea

“…Abstract Precision oncology therapies are significantly hindered by the emergence of genetically or epigenetically-distinct cellular sub-populations,…”
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