Search Results - "Subramani, Chithra"

Fumarate hydratase is a critical metabolic regulator of hematopoietic stem cell functions by Guitart, Amelie V, Panagopoulou, Theano I, Villacreces, Arnaud, Vukovic, Milica, Sepulveda, Catarina, Allen, Lewis, Carter, Roderick N, van de Lagemaat, Louie N, Morgan, Marcos, Giles, Peter, Sas, Zuzanna, Gonzalez, Marta Vila, Lawson, Hannah, Paris, Jasmin, Edwards-Hicks, Joy, Schaak, Katrin, Subramani, Chithra, Gezer, Deniz, Armesilla-Diaz, Alejandro, Wills, Jimi, Easterbrook, Aaron, Coman, David, So, Chi Wai Eric, O'Carroll, Donal, Vernimmen, Douglas, Rodrigues, Neil P, Pollard, Patrick J, Morton, Nicholas M, Finch, Andrew, Kranc, Kamil R

“…Strict regulation of stem cell metabolism is essential for tissue functions and tumor suppression. In this study, we investigated the role of fumarate…”
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Acute Loss of Cited2 Impairs Nanog Expression and Decreases Self‐Renewal of Mouse Embryonic Stem Cells by Kranc, Kamil R., Oliveira, Daniel V., Armesilla-Diaz, Alejandro, Pacheco-Leyva, Ivette, Catarina Matias, Ana, Luisa Escapa, Ana, Subramani, Chithra, Wheadon, Helen, Trindade, Marlene, Nichols, Jennifer, Kaji, Keisuke, Enver, Tariq, Bragança, José

“…Identifying novel players of the pluripotency gene regulatory network centered on Oct4, Sox2, and Nanog as well as delineating the interactions within the…”
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Adult hematopoietic stem cells lacking Hif-1α self-renew normally by Vukovic, Milica, Sepulveda, Catarina, Subramani, Chithra, Guitart, Amélie V., Mohr, Jasmine, Allen, Lewis, Panagopoulou, Theano I., Paris, Jasmin, Lawson, Hannah, Villacreces, Arnaud, Armesilla-Diaz, Alejandro, Gezer, Deniz, Holyoake, Tessa L., Ratcliffe, Peter J., Kranc, Kamil R.

“…The hematopoietic stem cell (HSC) pool is maintained under hypoxic conditions within the bone marrow microenvironment. Cellular responses to hypoxia are…”
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TGFβ pathway limits dedifferentiation following WNT and MAPK pathway activation to suppress intestinal tumourigenesis by Cammareri, Patrizia, Vincent, David F, Hodder, Michael C, Ridgway, Rachel A, Murgia, Claudio, Nobis, Max, Campbell, Andrew D, Varga, Julia, Huels, David J, Subramani, Chithra, Prescott, Katie L H, Nixon, Colin, Hedley, Ann, Barry, Simon T, Greten, Florian R, Inman, Gareth J, Sansom, Owen J

“…Recent studies have suggested increased plasticity of differentiated cells within the intestine to act both as intestinal stem cells (ISCs) and…”
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Hif-2α is not essential for cell-autonomous hematopoietic stem cell maintenance by Guitart, Amelie V., Subramani, Chithra, Armesilla-Diaz, Alejandro, Smith, Gillian, Sepulveda, Catarina, Gezer, Deniz, Vukovic, Milica, Dunn, Karen, Pollard, Patrick, Holyoake, Tessa L., Enver, Tariq, Ratcliffe, Peter J., Kranc, Kamil R.

“…Local hypoxia in hematopoietic stem cell (HSC) niches is thought to regulate HSC functions. Hypoxia-inducible factor-1 (Hif-1) and Hif-2 are key mediators of…”
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Hif-1α and Hif-2α synergize to suppress AML development but are dispensable for disease maintenance by Vukovic, Milica, Guitart, Amelie V, Sepulveda, Catarina, Villacreces, Arnaud, O'Duibhir, Eoghan, Panagopoulou, Theano I, Ivens, Alasdair, Menendez-Gonzalez, Juan, Iglesias, Juan Manuel, Allen, Lewis, Glykofrydis, Fokion, Subramani, Chithra, Armesilla-Diaz, Alejandro, Post, Annemarie E M, Schaak, Katrin, Gezer, Deniz, So, Chi Wai Eric, Holyoake, Tessa L, Wood, Andrew, O'Carroll, Dónal, Ratcliffe, Peter J, Kranc, Kamil R

“…Leukemogenesis occurs under hypoxic conditions within the bone marrow (BM). Knockdown of key mediators of cellular responses to hypoxia with shRNA, namely…”
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TGF[beta] pathway limits dedifferentiation following WNT and MAPK pathway activation to suppress intestinal tumourigenesis by Cammareri, Patrizia, Vincent, David F, Hodder, Michael C, Ridgway, Rachel A, Murgia, Claudio, Nobis, Max, Campbell, Andrew D, Varga, Julia, Huels, David J, Subramani, Chithra, Prescott, Katie L H, Nixon, Colin, Hedley, Ann, Barry, Simon T, Greten, Florian R, Inman, Gareth J, Sansom, Owen J

“…Recent studies have suggested increased plasticity of differentiated cells within the intestine to act both as intestinal stem cells (ISCs) and…”
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HIF-1α Is Not Essential For The Establishment Of MLL-Leukaemic Stem Cells by Gezer, Deniz, Guitart, Amelie V, Vukovic, Milica, Subramani, Chithra, Dunn, Karen, Pollard, Patrick, Ratcliffe, Peter J, Holyoake, Tessa L., Kranc, Kamil

“…Haematopoietic stem cells (HSCs) reside in hypoxic niches in the bone marrow (BM) and sustain long-life haematopoiesis. HSCs are largely quiescent, self-renew,…”
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The role of hypoxia signalling pathways in normal and leukaemic haemopoiesis by Subramani, Chithra

“…Although haemopoietic stem cells (HSCs) represent one of the best-defined stem cell systems, the pathways regulating HSC development and maintenance are not…”
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