Search Results - "Subleski, J."

Tumour-elicited neutrophils engage mitochondrial metabolism to circumvent nutrient limitations and maintain immune suppression by Rice, Christopher M., Davies, Luke C., Subleski, Jeff J., Maio, Nunziata, Gonzalez-Cotto, Marieli, Andrews, Caroline, Patel, Nimit L., Palmieri, Erika M., Weiss, Jonathan M., Lee, Jung-Min, Annunziata, Christina M., Rouault, Tracey A., Durum, Scott K., McVicar, Daniel W.

“…Neutrophils are a vital component of immune protection, yet in cancer they may promote tumour progression, partly by generating reactive oxygen species (ROS)…”
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Metabolic but not transcriptional regulation by PKM2 is important for natural killer cell responses by Walls, Jessica F, Subleski, Jeff J, Palmieri, Erika M, Gonzalez-Cotto, Marieli, Gardiner, Clair M, McVicar, Daniel W, Finlay, David K

“…Natural Killer (NK) cells have an important role in immune responses to viruses and tumours. Integrating changes in signal transduction pathways and cellular…”
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Immunotherapy of cancer by IL-12-based cytokine combinations by Weiss, Jonathan M, Subleski, Jeff J, Wigginton, Jon M, Wiltrout, Robert H

“…Cancer is a multi-faceted disease comprising complex interactions between neoplastic and normal cells. Over the past decade, there has been considerable…”
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Tumor-Infiltrating Myeloid Cells Co-Express TREM1 and TREM2 and Elevated TREM-1 Associates With Disease Progression in Renal Cell Carcinoma by Ford, Jill W, Gonzalez-Cotto, Marieli, MacFarlane, 4th, Alexander W, Peri, Suraj, Howard, O M Zack, Subleski, Jeffrey J, Ruth, Karen J, Haseebuddin, Mohammed, Al-Saleem, Tahseen, Yang, Youfeng, Rayman, Pat, Rini, Brian, Linehan, W Marston, Finke, James, Weiss, Jonathan M, Campbell, Kerry S, McVicar, Daniel W

“…Myeloid-derived suppressor cells (MDSC) and tumor-associated macrophages (TAM) contribute to cancer-related inflammation and tumor progression. While several…”
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Application of tissue-specific NK and NKT cell activity for tumor immunotherapy by Subleski, Jeff J, Wiltrout, Robert H, Weiss, Jonathan M

“…Abstract Natural killer (NK) and NKT cells are a first line of defense against pathogens and transformed cells. However, dysregulation of their function can…”
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Serum-based tracking of de novo initiated liver cancer progression reveals early immunoregulation and response to therapy by Subleski, Jeff J, Scarzello, Anthony J, Alvord, W. Gregory, Jiang, Qun, Stauffer, Jimmy K, Kronfli, Anthony, Saleh, Bahara, Back, Timothy, Weiss, Jonathan M, Wiltrout, Robert H

“…Abstract Background & Aims Liver inflammatory diseases associated with cancer promoting somatic oncogene mutations are increasing in frequency. Preclinical…”
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Successful Immunotherapy with IL-2/Anti-CD40 Induces the Chemokine-Mediated Mitigation of an Immunosuppressive Tumor Microenvironment by Weiss, Jonathan M., Back, Timothy C., Scarzello, Anthony J., Subleski, Jeff J., Hall, Veronica L., Stauffer, Jimmy K., Chen, Xin, Micic, Dejan, Alderson, Kory, Murphy, William J., Wiltrout, Robert H.

“…Treatment of mice bearing orthotopic, metastatic tumors with anti-CD40 antibody resulted in only partial, transient anti-tumor effects whereas combined…”
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Interleukin-15 Enhances Proteasomal Degradation of Bid in Normal Lymphocytes: Implications for Large Granular Lymphocyte Leukemias by HODGE, Deborah L, JUN YANG, LOUGHRAN, Thomas P, YOUNG, Howard A, BUSCHMAN, Matthew D, SCHAUGHENCY, Paul M, HONG DANG, BERE, William, YILI YANG, SAVAN, Ram, SUBLESKI, Jeff J, YIN, Xiao-Ming

“…Large granular lymphocyte (LGL) leukemia is a clonal proliferative disease of T and natural killer (NK) cells. Interleukin (IL)-15 is important for the…”
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Systemic IL-12 administration alters hepatic dendritic cell stimulation capabilities by Chan, Tim, Back, Timothy C, Subleski, Jeffrey J, Weiss, Jonathan M, Ortaldo, John R, Wiltrout, Robert H

“…The liver is an immunologically unique organ containing tolerogenic dendritic cells (DC) that maintain an immunosuppressive microenvironment. Although systemic…”
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IL-7 Administration Alters the CD4:CD8 Ratio, Increases T Cell Numbers, and Increases T Cell Function in the Absence of Activation by Geiselhart, Lisa A, Humphries, Courtney A, Gregorio, Theresa A, Mou, Sherry, Subleski, Jeffrey, Komschlies, Kristin L

“…IL-7 is vital for the development of the immune system and profoundly enhances the function of mature T cells. Chronic administration of IL-7 to mice markedly…”
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IFN-gamma and Fas/FasL are required for the antitumor and antiangiogenic effects of IL-12/pulse IL-2 therapy by Wigginton, J M, Gruys, E, Geiselhart, L, Subleski, J, Komschlies, K L, Park, J W, Wiltrout, T A, Nagashima, K, Back, T C, Wiltrout, R H

“…Systemic administration of IL-12 and intermittent doses of IL-2 induce complete regression of metastatic murine renal carcinoma. Here, we show that overt tumor…”
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Co-expression of TNFR2 and CD25 identifies more of the functional CD4⁺FOXP3⁺ regulatory T cells in human peripheral blood by Chen, Xin, Subleski, Jeffrey J, Hamano, Ryoko, Howard, O.M. Zack, Wiltrout, Robert H, Oppenheim, Joost J

“…Previously, we found that co-expression of CD25 and TNFR2 identified the most suppressive subset of mouse Treg. In this study, we report that human peripheral…”
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The proinflammatory cytokine interleukin-18 alters multiple signaling pathways to inhibit natural killer cell death by Hodge, Deborah L, Subleski, Jeff J, Reynolds, Della A, Buschman, Matthew D, Schill, William B, Burkett, Mark W, Malyguine, Anatoli M, Young, Howard A

“…The proinflammatory cytokine, interleukin-18 (IL-18), is a natural killer (NK) cell activator that induces NK cell cytotoxicity and interferon-gamma…”
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Peroxisome proliferator-activated receptor-γ and its ligands attenuate biologic functions of human natural killer cells by Zhang, Xia, Rodriguez-Galán, Maria Cecilia, Subleski, Jeff J., Ortaldo, John R., Hodge, Deborah L., Wang, Ji-Ming, Shimozato, Osamu, Reynolds, Della A., Young, Howard A.

“…Interferon-γ (IFN-γ) production and cytolytic activity are 2 major biologic functions of natural killer (NK) cells that are important for innate immunity. We…”
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Expression of costimulatory TNFR2 induces resistance of CD4+FoxP3- conventional T cells to suppression by CD4+FoxP3+ regulatory T cells by Chen, Xin, Hamano, Ryoko, Subleski, Jeffrey J, Hurwitz, Arthur A, Howard, O M Zack, Oppenheim, Joost J

“…Our previous study showed that TNFR2 is preferentially expressed by CD4(+)FoxP3(+) regulatory T cells (Tregs), and expression of this receptor identified…”
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IFN-gamma AU-rich element removal promotes chronic IFN-gamma expression and autoimmunity in mice by Hodge, Deborah L, Berthet, Cyril, Coppola, Vincenzo, Kastenmüller, Wolfgang, Buschman, Matthew D, Schaughency, Paul M, Shirota, Hidekazu, Scarzello, Anthony J, Subleski, Jeff J, Anver, Miriam R, Ortaldo, John R, Lin, Fanching, Reynolds, Della A, Sanford, Michael E, Kaldis, Philipp, Tessarollo, Lino, Klinman, Dennis M, Young, Howard A

“…Abstract We generated a mouse model with a 162 nt AU-rich element (ARE) region deletion in the 3′ untranslated region (3′UTR) of the interferon-gamma (IFN-γ)…”
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Regulatory T cells and myeloid-derived suppressor cells in the tumor microenvironment undergo Fas-dependent cell death during IL-2/αCD40 therapy by Weiss, Jonathan M, Subleski, Jeff J, Back, Tim, Chen, Xin, Watkins, Stephanie K, Yagita, Hideo, Sayers, Thomas J, Murphy, William J, Wiltrout, Robert H

“…Fas ligand expression in certain tumors has been proposed to contribute to immunosuppression and poor prognosis. However, immunotherapeutic approaches may…”
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Constitutive expression of functional CD40 on mouse renal cancer cells: Induction of Fas and Fas-mediated killing by CD40L by Lee, J.-K., Seki, N., Sayers, T.J., Subleski, J., Gruys, E.M., Murphy, W.J., Wiltrout, R.H.

“…CD40, a member of the TNF receptor superfamily, is expressed on B cells, dendritic cells, and some tumor cells, including melanoma and bladder carcinoma. In…”
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RelA is a potent transcriptional activator of the CD28 response element within the interleukin 2 promoter by Lai, Jenn-Haung, Horvath, GyöRgyi, Subleski, Jeff, Bruder, Joseph, Ghosh, Paritosh, Tan, Tse-Hua

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Enhanced antitumor response by divergent modulation of natural killer and natural killer T cells in the liver by SUBLESKI, Jeff J, HALL, Veronica L, BACK, Timothy C, ORTALDO, John R, WILTROUT, Robert H

“…The use of interleukin-18 (IL-18) together with IL-12 induced high levels of IFN-gamma in tumor-bearing mice and regression of liver tumors that was abolished…”
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