Search Results - "Subauste, Carlos S."

Interplay Between Toxoplasma gondii , Autophagy, and Autophagy Proteins by Subauste, Carlos S

“…Survival of within host cells depends on its ability of reside in a vacuole that avoids lysosomal degradation and enables parasite replication. The interplay…”
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CD40 in Retinal Müller Cells Induces P2X7-Dependent Cytokine Expression in Macrophages/Microglia in Diabetic Mice and Development of Early Experimental Diabetic Retinopathy by Portillo, Jose-Andres C, Lopez Corcino, Yalitza, Miao, Yanling, Tang, Jie, Sheibani, Nader, Kern, Timothy S, Dubyak, George R, Subauste, Carlos S

“…Müller cells and macrophages/microglia are likely important for the development of diabetic retinopathy; however, the interplay between these cells in this…”
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Recent Advances in the Roles of Autophagy and Autophagy Proteins in Host Cells During Toxoplasma gondii Infection and Potential Therapeutic Implications by Subauste, Carlos S

“…is an obligate intracellular protozoan that can cause encephalitis and retinitis in humans. The success of as a pathogen depends in part on its ability to form…”
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Toxoplasma gondii-induced activation of EGFR prevents autophagy protein-mediated killing of the parasite by Muniz-Feliciano, Luis, Van Grol, Jennifer, Portillo, Jose-Andres C, Liew, Lloyd, Liu, Bing, Carlin, Cathleen R, Carruthers, Vern B, Matthews, Stephen, Subauste, Carlos S

“…Toxoplasma gondii resides in an intracellular compartment (parasitophorous vacuole) that excludes transmembrane molecules required for endosome-lysosome…”
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Disruption of retinal inflammation and the development of diabetic retinopathy in mice by a CD40-derived peptide or mutation of CD40 in Müller cells by Portillo, Jose-Andres C., Yu, Jin-Sang, Vos, Sarah, Bapputty, Reena, Lopez Corcino, Yalitza, Hubal, Alyssa, Daw, Jad, Arora, Sahil, Sun, Wenyu, Lu, Zheng-Rong, Subauste, Carlos S.

“…Aims/hypothesis CD40 expressed in Müller cells is a central driver of diabetic retinopathy. CD40 causes phospholipase Cγ1 (PLCγ1)-dependent ATP release in…”
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Animal Models for Toxoplasma gondii Infection by S Subauste, Carlos, Hubal, Alyssa

“…Toxoplasma gondii is an obligate intracellular protozoan parasite that commonly infects mammals and birds throughout the world. This protocol describes murine…”
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Toxoplasma gondii induces FAK-Src-STAT3 signaling during infection of host cells that prevents parasite targeting by autophagy by Portillo, Jose-Andres C, Muniz-Feliciano, Luis, Lopez Corcino, Yalitza, Lee, So Jung, Van Grol, Jennifer, Parsons, Sarah J, Schiemman, William P, Subauste, Carlos S

“…Targeting of Toxoplasma gondii by autophagy is an effective mechanism by which host cells kill the protozoan. Thus, the parasite must avoid autophagic…”
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HIV-1 inhibits autophagy in bystander macrophage/monocytic cells through Src-Akt and STAT3 by Van Grol, Jennifer, Subauste, Cecilia, Andrade, Rosa M, Fujinaga, Koh, Nelson, Julie, Subauste, Carlos S

“…Autophagy is a homeostatic mechanism of lysosomal degradation. Defective autophagy has been linked to various disorders such as impaired control of pathogens…”
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Identification of Signaling Pathways by Which CD40 Stimulates Autophagy and Antimicrobial Activity against Toxoplasma gondii in Macrophages by Liu, Elizabeth, Lopez Corcino, Yalitza, Portillo, Jose-Andres C, Miao, Yanling, Subauste, Carlos S

“…CD40 is an important stimulator of autophagy and autophagic killing of Toxoplasma gondii in host cells. In contrast to autophagy induced by nutrient…”
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Di-retinoid-pyridinium-ethanolamine (A2E) Accumulation and the Maintenance of the Visual Cycle Are Independent of Atg7-mediated Autophagy in the Retinal Pigmented Epithelium by Perusek, Lindsay, Sahu, Bhubanananda, Parmar, Tanu, Maeno, Hiroshi, Arai, Eisuke, Le, Yun-Zheng, Subauste, Carlos S., Chen, Yu, Palczewski, Krzysztof, Maeda, Akiko

“…Autophagy is an evolutionarily conserved catabolic mechanism that relieves cellular stress by removing/recycling damaged organelles and debris through the…”
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CD40 Induces Anti-Toxoplasma gondii Activity in Nonhematopoietic Cells Dependent on Autophagy Proteins by Van Grol, Jennifer, Muniz-Feliciano, Luis, Portillo, Jose-Andres C, Bonilha, Vera L, Subauste, Carlos S

“…Classifications Services IAI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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CD40-TRAF Signaling Upregulates CX3CL1 and TNF-α in Human Aortic Endothelial Cells but Not in Retinal Endothelial Cells by Greene, Jennifer A, Portillo, Jose-Andres C, Lopez Corcino, Yalitza, Subauste, Carlos S

“…CD40, CX3CL1 and TNF-α promote atheroma and neointima formation. CD40 and TNF-α are also central to the development of diabetic retinopathy while CX3CL1 may…”
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Advanced Glycation End Products Upregulate CD40 in Human Retinal Endothelial and Müller Cells: Relevance to Diabetic Retinopathy by Portillo, Jose-Andres C, Pfaff, Amelia, Vos, Sarah, Weng, Matthew, Nagaraj, Ram H, Subauste, Carlos S

“…CD40 induces pro-inflammatory responses in endothelial and Müller cells and is required for the development of diabetic retinopathy (DR). CD40 is upregulated…”
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Modulation of retinal Müller cells by complement receptor C5aR by Cheng, Lijia, Bu, Hong, Portillo, Jose-Andres C, Li, Yan, Subauste, Carlos S, Huang, Suber S, Kern, Timothy S, Lin, Feng

“…Müller cells, a major type of glial cell found in the eye, are postulated to play an important role in many retinal diseases, including diabetic retinopathy…”
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The CD40-autophagy pathway is needed for host protection despite IFN-Γ-dependent immunity and CD40 induces autophagy via control of P21 levels by Portillo, Jose-Andres C, Okenka, Genevieve, Reed, Erin, Subauste, Angela, Van Grol, Jennifer, Gentil, Katrin, Komatsu, Masaaki, Tanaka, Keiji, Landreth, Gary, Levine, Beth, Subauste, Carlos S

“…Autophagy degrades pathogens in vitro. The autophagy gene Atg5 has been reported to be required for IFN-γ-dependent host protection in vivo. However, these…”
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Blockade of CD40–TRAF2,3 or CD40–TRAF6 is sufficient to inhibit pro‐inflammatory responses in non‐haematopoietic cells by Portillo, Jose‐Andres C., Greene, Jennifer A., Schwartz, Isaac, Subauste, Maria Cecilia, Subauste, Carlos S.

“…Summary Inhibition of the CD40–CD154 pathway controls inflammatory disorders. Unfortunately, administration of anti‐CD154 monoclonal antibodies causes…”
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The CD40-ATP-P2X7 Receptor Pathway: Cell to Cell Cross-Talk to Promote Inflammation and Programmed Cell Death of Endothelial Cells by Subauste, Carlos S.

“…Extracellular adenosine 5′-triphosphate (ATP) functions not only as a neurotransmitter but is also released by non-excitable cells and mediates cell–cell…”
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CD40, a Novel Inducer of Purinergic Signaling: Implications to the Pathogenesis of Experimental Diabetic Retinopathy by Subauste, Carlos S

“…Diabetic retinopathy is a leading complication of diabetes. Death of capillary cells with resulting capillary degeneration is a central feature of this…”
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CD40 Restrains In Vivo Growth of Toxoplasma gondii Independently of Gamma Interferon by Subauste, Carlos S, Wessendarp, Matthew

“…CD40-CD154 interaction is pivotal for resistance against numerous pathogens. However, it is not known if this pathway can also enhance in vivo resistance in…”
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CD40 Upregulation in the Retina of Patients With Diabetic Retinopathy: Association With TRAF2/TRAF6 Upregulation and Inflammatory Molecule Expression by Vos, Sarah, Aaron, Rachel, Weng, Matthew, Daw, Jad, Rodriguez-Rivera, Emmanuel, Subauste, Carlos S

“…CD40 is upregulated in the retinas of diabetic mice, drives pro-inflammatory molecule expression, and promotes diabetic retinopathy. The role of CD40 in…”
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