Search Results - "Subasinghe, Nalin L."

Discovery and optimization of a novel series of pyrazolyltetrahydropyran N-type calcium channel (Cav 2.2) blockers for the treatment of pain by Wall, Mark J., Subasinghe, Nalin L., Winters, Michael P., Lubin, Mary Lou, Finley, Michael F.A., Qin, Ning, Brandt, Michael R., Neeper, Michael P., Schneider, Craig R., Colburn, Raymond W., Flores, Christopher M., Sui, Zhihua

“…[Display omitted] •Optimized a novel series of pyrazoles as potent N-type calcium channel blockers.•Compounds 9 and 22 were orally bioavailable in…”
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A novel series of N-(azetidin-3-yl)-2-(heteroarylamino)acetamide CCR2 antagonists by Subasinghe, Nalin L., Lanter, James, Markotan, Thomas, Opas, Evan, McKenney, Sandra, Crysler, Carl, Hou, Cuifen, O’Neill, John, Johnson, Dana, Sui, Zhihua

“…The inflammatory response associated with the activation of C–C chemokine receptor CCR2 via it’s interaction with the monocyte chemoattractant protein-1…”
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A novel series of pyrazolylpiperidine N-type calcium channel blockers by Subasinghe, Nalin L., Wall, Mark J., Winters, Michael P., Qin, Ning, Lubin, Mary Lou, Finley, Michael F.A., Brandt, Michael R., Neeper, Michael P., Schneider, Craig R., Colburn, Raymond W., Flores, Christopher M., Sui, Zhihua

“…Selective blockers of the N-type calcium channel have proven to be effective in animal models of chronic pain. However, even though intrathecally delivered…”
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Design and synthesis of polyethylene glycol-modified biphenylsulfonyl-thiophene-carboxamidine inhibitors of the complement component C1s by Subasinghe, Nalin L., Khalil, Ehab, Travins, Jeremy M., Ali, Farah, Ballentine, Shelley K., Hufnagel, Heather R., Pan, Wenxi, Leonard, Kristi, Bone, Roger F., Soll, Richard M., Crysler, Carl S., Ninan, Nisha, Kirkpatrick, Jennifer, Kolpak, Michael X., Diloreto, Karen A., Eisennagel, Stephen H., Huebert, Norman D., Molloy, Christopher J., Tomczuk, Bruce E., Gaul, Michael D.

“…Complement C1s protease inhibitors have potential utility in the treatment of diseases associated with activation of the classical complement pathway such as…”
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Biphenylsulfonyl-thiophene-carboxamidine inhibitors of the complement component C1s by Travins, Jeremy M., Ali, Farah, Huang, Hui, Ballentine, Shelley K., Khalil, Ehab, Hufnagel, Heather R., Pan, Wenxi, Gushue, Joan, Leonard, Kristi, Bone, Roger F., Soll, Richard M., DesJarlais, Renee L., Crysler, Carl S., Ninan, Nisha, Kirkpatrick, Jennifer, Cummings, Maxwell D., Huebert, Norman, Molloy, Christopher J., Gaul, Michael, Tomczuk, Bruce E., Subasinghe, Nalin L.

“…Complement activation has been implicated in disease states such as hereditary angioedema, ischemia-reperfusion injury, acute respiratory distress syndrome,…”
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A novel series of arylsulfonylthiophene-2-carboxamidine inhibitors of the complement component C1s by Subasinghe, Nalin L., Travins, Jeremy M., Ali, Farah, Huang, Hui, Ballentine, Shelley K., Marugán, Juan José, Khalil, Ehab, Hufnagel, Heather R., Bone, Roger F., DesJarlais, Renee L., Crysler, Carl S., Ninan, Nisha, Cummings, Maxwell D., Molloy, Christopher J., Tomczuk, Bruce E.

“…Inhibiting the classical pathway of complement activation by attenuating the proteolytic activity of the serine protease C1s is a potential strategy for the…”
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A novel series of potent and selective small molecule inhibitors of the complement component C1s by Subasinghe, Nalin L., Ali, Farah, Illig, Carl R., Jonathan Rudolph, M., Klein, Scott, Khalil, Ehab, Soll, Richard M., Bone, Roger F., Spurlino, John C., DesJarlais, Renee L., Crysler, Carl S., Cummings, Maxwell D., Morris, Philip E., Kilpatrick, John M., Sudhakara Babu, Y.

“…Graphic Activation of the classical pathway of complement has been implicated in disease states such as hereditary angioedema, ischemia-reperfusion injury and…”
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Design and Synthesis of 4,5-Disubstituted-thiophene-2-amidines as Potent Urokinase Inhibitors by Rudolph, M.Jonathan, Illig, Carl R., Subasinghe, Nalin L., Wilson, Kenneth J., Hoffman, James B., Randle, Troy, Green, David, Molloy, Chris J., Soll, Richard M., Lewandowski, Frank, Zhang, Marie, Bone, Roger, Spurlino, John C., Deckman, Ingrid C., Manthey, Carl, Sharp, Celia, Maguire, Diane, Grasberger, Bruce L., DesJarlais, Renée L., Zhou, Zhao

“…A study of the S1 binding of lead 5-methylthiothiophene amidine 3, an inhibitor of urokinase-type plasminogen activator, was undertaken by the introduction of…”
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An efficient and high yield method for the N- tert-butoxycarbonyl protection of sterically hindered amino acids by Khalil, Ehab M., Subasinghe, Nalin L., Johnson, Rodney L.

“…An improved method for the N- tert-butoxycarbonyl protection of the amino functionality of α-alkylated prolines and other sterically hindered α,α-disubstituted…”
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Bicyclic thiazolidine lactam peptidomimetics of the dopamine receptor modulating peptide Pro-Leu-Gly-NH2 by Subasinghe, Nalin L, Bontems, Roger J, McIntee, Edward, Mishra, Ram K, Johnson, Rodney L

“…Bicyclic thiazolidine lactam peptidomimetics 3-5 have been synthesized as potential analogues of the dopamine receptor modulating peptide Pro-Leu-Gly-NH2…”
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Structure-Based design, synthesis and sAR of a novel series of thiopheneamidine urokinase plasminogen activator inhibitors by Subasinghe, Nalin L., Illig, Carl, Hoffman, James, Rudolph, M.Jonathan, Wilson, Kenneth J., Soll, Richard, Randle, Troy, Green, David, Lewandowski, Frank, Zhang, Marie, Bone, Roger, Spurlino, John, DesJarlais, Renee, Deckman, Ingrid, Molloy, Christopher J., Manthey, Carl, Zhou, Zhau, Sharp, Celia, Maguire, Diane, Crysler, Carl, Grasberger, Bruce

“…The serine protease urokinase plasminogen activator (uPA) is thought to play a central role in tumor metastasis and angiogenesis. Molecular modeling studies…”
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Stereospecific synthesis of 2-substituted bicyclic thiazolidine lactams by Subasinghe, Nalin L., Khalil, Ehab M., Johnson, Rodney L.

“…Bicyclic thiazolidine lactam 1 was used as a model system for developing synthetic methodology into β-turn mimics that would contain side chain functionality…”
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