Search Results - "Suarez, J. D"

On the growth of supermassive black holes formed from the gravitational collapse of fermionic dark matter cores by Argüelles, C R, Boshkayev, K, Krut, A, Nurbakhyt, G, Rueda, J A, Ruffini, R, Uribe-Suárez, J D, Yunis, R

“…ABSTRACT Observations support the idea that supermassive black holes (SMBHs) power the emission at the centre of active galaxies. However, contrary to…”
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MeV, GeV and TeV Neutrinos from Binary-Driven Hypernovae by Campion, S., Uribe-Suárez, J. D., Melon Fuksman, J. D., Rueda, J. A.

“…We analyze neutrino emission channels in energetic (≳1052 erg) long gamma-ray bursts within the binary-driven hypernova model. The binary-driven hypernova…”
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Rat Epididymal Sperm Quantity, Quality, and Transit Time after Guanethidine-Induced Sympathectomy by Kempinas, W D, Suarez, J D, Roberts, N L, Strader, L, Ferrell, J, Goldman, J M, Klinefelter, G R

“…Guanethidine, a chemical that selectively abolishes peripheral noradrenergic nerves, was used to investigate the role of sympathetic innervation in the…”
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Spermatotoxicity of dichloroacetic acid by Linder, Ralph E., Klinefelter, Gary R., Strader, Lillian F., Suarez, Juan D., Roberts, Naomi L.

“…The testicular toxicity of dichloroacetic acid (DCA), a disinfection byproduct of drinking water, was evaluated in adult male rats given both single and…”
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Discriminant analysis indicates a single sperm protein (SP22) is predictive of fertility following exposure to epididymal toxicants by Klinefelter, G. R, Laskey, J. W, Ferrell, J, Suarez, J. D, Roberts, N. L

“…In a previous study, we found that ethane dimethanesulphonate (EDS) compromised the fertilizing ability of proximal cauda epididymal sperm from the rat within…”
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Insights into toxicology, safety pharmacology, and drug dependence testing: The performance and predictive values of nonclinical tests by Suarez-Torres, J.D., Ciangherotti, C.E., Jimenez-Orozco, F.A.

“…The pre-marketing testing of drugs and chemicals is now a paradigm of contribution to the safeguard of public health. As pointed out by the ICH concept paper…”
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Fertility of Rat Epididymal Sperm after Chemically and Surgically Induced Sympathectomy by DE G. KEMPINAS, W, SUAREZ, J. D, KLINEFELTER, G. R, ROBERTS, N. L, STRADER, L. F, FERRELL, J, GOLDMAN, J. M, NAROTSKY, M. G, PERREAULT, S. D, EVENSON, D. P, RICKER, D. D

“…Guanethidine, a chemical that selectively blocks sympathetic noradrenergic neurons, was used to investigate the role of sympathetic innervation in the…”
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Localization of the sperm protein SP22 and inhibition of fertility in vivo and in vitro by Klinefelter, G. R, Welch, J. E, Perreault, S. D, Moore, H. D, Zucker, R. M, Suarez, J. D, Roberts, N. L, Bobseine, K, Jeffay, S

“…We previously established that levels of the sperm membrane protein, SP22, are highly correlated with the fertility of sperm from the cauda epididymidis of…”
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Chloroethylmethanesulfonate-induced effects on the epididymis seem unrelated to altered Leydig cell function by KLINEFELTER, G. R, LASKEY, J. W, KELCE, W. R, FERRELL, J, ROBERTS, N. L, SUAREZ, J. D, SLOTT, V

“…Decades ago it was reported that when male rats were exposed to chloroethylmethanesulfonate (CEMS) for 5 days prior to weekly matings with untreated females,…”
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Toxicant-induced acceleration of epididymal sperm transit: Androgen-dependent proteins may be involved by Klinefelter, Gary R, Suarez, Juan D

“…Previously we established that a 4-d exposure to chloroethylmethanesulphonate (CEMS), a chemical that significantly reduces serum testosterone (T) levels,…”
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Histopathologic changes in the testes of rats exposed to dibromoacetic acid by Linder, Ralph E., Klinefelter, Gary R., Strader, Lillian F., Veeramachaneni, D.N.Rao, Roberts, Naomi L., Suarez, Juan D.

“…The present report details histopathologic changes in the testis and epididymis of rats gavaged daily for 2 to 79 d with a by-product of water disinfection,…”
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Spermatotoxicity of dibromoacetic acid in rats after 14 daily exposures by Linder, R E, Klinefelter, G R, Strader, L F, Suarez, J D, Roberts, N L, Dyer, C J

“…Halogenated acetic acids are major disinfection by-products of water chlorination and ozonation. Limited data in experimental animals indicate that repeated…”
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SP22: a novel fertility protein from a highly conserved gene family by Welch, J. E, Barbee, R. R, Roberts, N. L, Suarez, J. D, Klinefelter, G. R

“…Three nucleotide sequences encoding SP22, a protein originally identified in detergent extracts of cauda epididymal sperm, were isolated from a rat testis cDNA…”
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Dibromoacetic acid, a prevalent by-product of drinking water disinfection, compromises the synthesis of specific seminiferous tubule proteins following both in vivo and in vitro exposures by Holmes, M, Suarez, J. D, Roberts, N. L, Mole, M. L, Murr, A. S, Klinefelter, G. R

“…Dibromoacetic acid (DBA) is a by‐product of drinking water disinfection that alters spermatogenesis in adult male rats. To identify a mechanism by which DBA…”
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Rat sperm motility analysis: methodologic considerations by Slott, V L, Suarez, J D, Perreault, S D

“…The objective of these studies was to optimize conditions for computer-assisted sperm analysis (CASA) of rat epididymal spermatozoa. Methodologic issues…”
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Bromochloroacetic Acid Exerts Qualitative Effects on Rat Sperm: Implications for a Novel Biomarker by Klinefelter, Gary R., Strader, Lillian F., Suarez, Juan D., Roberts, Naomi L.

“…Disubstituted haloacid by-products of drinking water disinfection such as dibromoacetic acid and dichloroacetic acid have been shown to perturb spermatogenesis…”
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Preliminary screening for the potential of drinking water disinfection byproducts to alter male reproduction by Klinefelter, Gary R., Suarez, Juan D., Roberts, Naomi L., DeAngelo, Anthony B.

“…There is increasing epidemiologic interest in the role drinking water disinfection byproducts (DBPs) may play in adverse reproductive outcomes such as…”
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Endpoints of spermatotoxicity in the rat after short duration exposures to fourteen reproductive toxicants by Linder, R E, Strader, L F, Slott, V L, Suarez, J D

“…Multiple endpoints of spermatotoxicity in short duration tests (1-5 days exposure; 2.5-week assay interval) were investigated in a number of chemicals reported…”
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Synchronous assessment of sperm motility and fertilizing ability in the hamster following treatment with alpha-chlorohydrin by Slott, V. L, Jeffay, S. C, Suarez, J. D, Barbee, R. R, Perreault, S. D

“…To Investigate the relationship between sperm motion parameters and fertilizing ability, a model was developed to assess both of these endpoints synchronously…”
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Dibromoacetic acid affects reproductive competence and sperm quality in the male rat by Linder, R E, Klinefelter, G R, Strader, L F, Narotsky, M G, Suarez, J D, Roberts, N L, Perreault, S D

“…Recently, we demonstrated with short-duration tests that dibromoacetic acid (DBAA), a commonly occurring by-product of water disinfection, alters sperm…”
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