Search Results - "Suarez, Irina"
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Principles of miRNA/miRNA function in plant MIRNA processing
Published in Nucleic acids research (12-08-2024)“…Abstract MicroRNAs (miRNAs) are essential regulators of gene expression, defined by their unique biogenesis, which requires the precise excision of the small…”
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Structural Insights in Multifunctional Papillomavirus Oncoproteins
Published in Viruses (15-01-2018)“…Since their discovery in the mid-eighties, the main papillomavirus oncoproteins E6 and E7 have been recalcitrant to high-resolution structure analysis…”
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Efficiency and precision of microRNA biogenesis modes in plants
Published in Nucleic acids research (16-11-2018)“…Abstract Many evolutionarily conserved microRNAs (miRNAs) in plants regulate transcription factors with key functions in development. Hence, mutations in the…”
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The key role of electrostatic interactions in the induced folding in RNA recognition by DCL1-A
Published in Physical chemistry chemical physics : PCCP (2018)“…The intrinsically disordered protein domain DCL1-A is the first report of a complete double stranded RNA binding domain folding upon binding. DCL1-A recognizes…”
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Induced folding in RNA recognition by Arabidopsis thaliana DCL1
Published in Nucleic acids research (27-07-2015)“…DCL1 is the ribonuclease that carries out miRNA biogenesis in plants. The enzyme has two tandem double stranded RNA binding domains (dsRBDs) in its C-terminus…”
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dsRNA-protein interactions studied by molecular dynamics techniques. Unravelling dsRNA recognition by DCL1
Published in Archives of biochemistry and biophysics (15-04-2016)“…Double stranded RNA (dsRNA) participates in several biological processes, where RNA molecules acquire secondary structure inside the cell through base…”
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Second Double-Stranded RNA Binding Domain of Dicer-like Ribonuclease 1: Structural and Biochemical Characterization
Published in Biochemistry (Easton) (21-12-2012)“…Dicer-like ribonuclease III enzymes are involved in different paths related to RNA silencing in plants. Little is known about the structural aspects of these…”
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The GEF Trio controls endothelial cell size and arterial remodeling downstream of Vegf signaling in both zebrafish and cell models
Published in Nature communications (21-10-2020)“…Arterial networks enlarge in response to increase in tissue metabolism to facilitate flow and nutrient delivery. Typically, the transition of a growing artery…”
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dab2 is required for the scavenging function of lymphatic endothelial cells in the zebrafish meninges
Published in Scientific reports (14-11-2024)“…To date it is only partially understood how the brain is cleared of waste products resulting from its high metabolic activity, although this process has…”
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NMDA Receptor Autoantibodies in Autoimmune Encephalitis Cause a Subunit-Specific Nanoscale Redistribution of NMDA Receptors
Published in Cell reports (Cambridge) (26-06-2018)“…Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis is a severe neuropsychiatric disorder mediated by autoantibodies against the GluN1 subunit of the…”
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Cells with Many Talents: Lymphatic Endothelial Cells in the Brain Meninges
Published in Cells (Basel, Switzerland) (02-04-2021)“…The lymphatic system serves key functions in maintaining fluid homeostasis, the uptake of dietary fats in the small intestine, and the trafficking of immune…”
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Functionalized Surfaces with Tailored Wettability Determine Influenza A Infectivity
Published in ACS applied materials & interfaces (22-06-2016)“…Surfaces contaminated with pathogenic microorganisms contribute to their transmission and spreading. The development of “active surfaces” that can reduce or…”
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A novel small-molecule inhibitor of the human papillomavirus E6-p53 interaction that reactivates p53 function and blocks cancer cells growth
Published in Cancer letters (01-02-2020)“…Despite prophylactic vaccination campaigns, human papillomavirus (HPV)-induced cancers still represent a major medical issue for global population, thus…”
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Structure of High-Risk Papillomavirus 31 E6 Oncogenic Protein and Characterization of E6/E6AP/p53 Complex Formation
Published in Journal of virology (22-12-2020)“…The degradation of p53 is a hallmark of high-risk human papillomaviruses (HPVs) of the alpha genus and HPV-related carcinogenicity. The oncoprotein E6 forms a…”
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High-Risk Mucosal Human Papillomavirus 16 (HPV16) E6 Protein and Cutaneous HPV5 and HPV8 E6 Proteins Employ Distinct Strategies To Interfere with Interferon Regulatory Factor 3-Mediated Beta Interferon Expression
Published in Journal of virology (25-05-2022)“…Persistent infection with some mucosal α-genus human papillomaviruses (HPVs; the most prevalent one being HPV16) can induce cervical carcinoma, anogenital…”
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Structure of high-risk papillomavirus type 31 E6 oncogenic protein and characterization of E6/E6AP/p53 complex formation
Published in Journal of virology (22-12-2020)“…Variations of carcinogenicity of human papillomaviruses are related to variations of the E6 and E7 interactome. While different HPV species and genera are…”
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Mes de la Ciencia: estrategia para el conocimiento y la investigación
Published in Revista médica electrónica (2024)“…RESUMEN El Mes de la Ciencia surge como idea para socializar y divulgar las investigaciones y el nivel de actualización sobre los principales problemas de…”
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Necesidades de aprendizaje de los licenciados en Enfermería sobre el asma bronquial
Published in Humanidades médicas (01-08-2021)“…RESUMEN Introducción: El asma es una enfermedad psicosomática que reduce la calidad de vida de quien la padece, y tiene el riesgo de progresar en intensidad…”
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Caracterización clinicoepidemiológica de niñas y niños con sepsis en un hospital pediátrico
Published in Medisan (01-07-2012)“…Se realizó un estudio descriptivo y transversal de 36 niños con sepsis ingresados en la Unidad de Cuidados Intensivos del Hospital Infantil Norte "Juan de la…”
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Caracterización clinicoepidemiológica de niñas y niños con sepsis en un hospital pediátrico Clinical epidemiological characterization of children with sepsis in a pediatric hospital
Published in Medisan (01-07-2012)“…Se realizó un estudio descriptivo y transversal de 36 niños con sepsis ingresados en la Unidad de Cuidados Intensivos del Hospital Infantil Norte "Juan de la…”
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