Search Results - "Suarez, Ignacio Gonzalez"

Systems toxicology assessment of a representative e-liquid formulation using human primary bronchial epithelial cells by Marescotti, Diego, Mathis, Carole, Belcastro, Vincenzo, Leroy, Patrice, Acali, Stefano, Martin, Florian, Dulize, Rémi, Bornand, David, Peric, Dariusz, Guedj, Emmanuel, Ortega Torres, Laura, Biasioli, Matteo, Fuhrimann, Matthieu, Fernandes, Estela, Frauendorfer, Felix, Gonzalez Suarez, Ignacio, Sciuscio, Davide, Ivanov, Nikolai V., Peitsch, Manuel C., Hoeng, Julia

“…[Display omitted] •A 3-step approach combining 1) real-time cytotoxicity, 2) high-content screening and 3) gene expression analysis was developed in NHBE…”
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Novel roles for A‐type lamins in telomere biology and the DNA damage response pathway by Gonzalez‐Suarez, Ignacio, Redwood, Abena B, Perkins, Stephanie M, Vermolen, Bart, Lichtensztejin, Daniel, Grotsky, David A, Morgado‐Palacin, Lucia, Gapud, Eric J, Sleckman, Barry P, Sullivan, Teresa, Sage, Julien, Stewart, Colin L, Mai, Sabine, Gonzalo, Susana

“…A‐type lamins are intermediate filament proteins that provide a scaffold for protein complexes regulating nuclear structure and function. Mutations in the LMNA…”
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A new pathway that regulates 53BP1 stability implicates Cathepsin L and vitamin D in DNA repair by Gonzalez-Suarez, Ignacio, Redwood, Abena B, Grotsky, David A, Neumann, Martin A, Cheng, Emily H-Y, Stewart, Colin L, Dusso, Adriana, Gonzalo, Susana

“…Genomic instability due to telomere dysfunction and defective repair of DNA double‐strand breaks (DSBs) is an underlying cause of ageing‐related diseases…”
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Loss of A-type lamins and genomic instability by Gonzalez-Suarez, Ignacio, Redwood, Abena B., Gonzalo, Susana

“…Research performed in the last few years has revealed important roles for the spatial and temporal organization of the genome on genome function and integrity…”
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Regulating the levels of key factors in cell cycle and DNA repair: New pathways revealed by lamins by Redwood, Abena B., Gonzalez-Suarez, Ignacio, Gonzalo, Susana

“…Spatial and temporal organization of the genome represents an additional step in the regulation of nuclear functions. The nuclear lamina, a polymeric meshwork…”
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BRCA1 loss activates cathepsin L-mediated degradation of 53BP1 in breast cancer cells by Grotsky, David A, Gonzalez-Suarez, Ignacio, Novell, Anna, Neumann, Martin A, Yaddanapudi, Sree C, Croke, Monica, Martinez-Alonso, Montserrat, Redwood, Abena B, Ortega-Martinez, Sylvia, Feng, Zhihui, Lerma, Enrique, Ramon y Cajal, Teresa, Zhang, Junran, Matias-Guiu, Xavier, Dusso, Adriana, Gonzalo, Susana

“…Loss of 53BP1 rescues BRCA1 deficiency and is associated with BRCA1-deficient and triple-negative breast cancers (TNBC) and with resistance to genotoxic drugs…”
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A dual role for A-type lamins in DNA double-strand break repair by Redwood, Abena B., Perkins, Stephanie M., Vanderwaal, Robert P., Feng, Zhihui, Biehl, Kenneth J., Gonzalez-Suarez, Ignacio, Morgado-Palacin, Lucia, Shi, Wei, Sage, Julien, Roti-Roti, Joseph L., Stewart, Colin L., Zhang, Junran, Gonzalo, Susana

“…A-type lamins are emerging as regulators of nuclear organization and function. Changes in their expression are associated with cancer and mutations are linked…”
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The role of RPA2 phosphorylation in homologous recombination in response to replication arrest by Shi, Wei, Feng, Zhihui, Zhang, Jiuqin, Gonzalez-Suarez, Ignacio, Vanderwaal, Robert P., Wu, Xiaohua, Powell, Simon N., Roti Roti, Joseph L., Gonzalo, Susana, Zhang, Junran

“…Failure to reactivate stalled or collapsed DNA replication forks is a potential source of genomic instability. Homologous recombination (HR) is a major…”
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High Content Screening Analysis to Evaluate the Toxicological Effects of Harmful and Potentially Harmful Constituents (HPHC) by Marescotti, Diego, Gonzalez Suarez, Ignacio, Acali, Stefano, Johne, Stephanie, Laurent, Alexandra, Frentzel, Stefan, Hoeng, Julia, Peitsch, Manuel C

“…Cigarette smoke (CS) is a major risk factor for cardiovascular and lung diseases. Because CS is a complex aerosol containing more than 7,000 chemicals it is…”
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Nurturing the genome: A-type lamins preserve genomic stability by Gonzalez-Suarez, Ignacio, Gonzalo, Susana

“…A-type lamins provide a scaffold for tethering chromatin and protein complexes regulating nuclear structure and function. Interest in lamins increased after…”
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EGFR Activation Increases Parathyroid Hyperplasia and Calcitriol Resistance in Kidney Disease by ARCIDIACONO, Maria Vittoria, SATO, Tetsuhiko, DUSSO, Adriana S, ALVAREZ-HERNANDEZ, Daniel, JING YANG, TOKUMOTO, Masanori, GONZALEZ-SUAREZ, Ignacio, YAN LU, TOMINAGA, Yoshihiro, CANNATA-ANDIA, Jorge, SLATOPOLSKY, Eduardo

“…Calcitriol, acting through vitamin D receptors (VDR) in the parathyroid, suppresses parathyroid hormone synthesis and cell proliferation. In secondary…”
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Novel roles for A-type lamins in telomere biology and the DNA damage response pathway by Gonzalez-Suarez, Ignacio, Redwood, Abena B, Perkins, Stephanie M, Vermolen, Bart, Lichtensztejin, Daniel, Grotsky, David A, Morgado-Palacin, Lucia, Gapud, Eric J, Sleckman, Barry P, Sullivan, Teresa, Sage, Julien, Stewart, Colin L, Mai, Sabine, Gonzalo, Susana

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Residue 826 in the Calcium-Sensing Receptor Is Implicated in the Response to Calcium and to R-568 Calcimimetic Compound by Álvarez-Hernández, Daniel, González-Suárez, Ignacio, Fernández-Martín, José L., Rodríguez, Isabel, Santamaría, Íñigo, Coto, Eliecer, Cannata-Andía, Jorge B.

“…Within the extracellular loops of the seven-transmembrane domain of the calcium-sensing receptor (CaR) there is a region (I819–E837) relevant for calcimimetic…”
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Aluminum posttranscriptional regulation of parathyroid hormone synthesis: A role for the calcium-sensing receptor by Gonzelez-Suerez, Ignacio, ÁLvarez-Hernendez, Daniel, Carrillo-Lepez, Natalia, Naves-Deaz, Manuel, Luis Fernendez-Marten, Jose, Cannata-Andea, Jorge B.

“…Aluminum posttranscriptional regulation of parathyroid hormone synthesis: A role for the calcium-sensing receptor. Calcium regulates parathyroid hormone (PTH)…”
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Viability and functionality of fresh and cryopreserved human hyperplastic parathyroid tissue tested in vitro by Alvarez-Hernández, Daniel, González-Suárez, Ignacio, Carrillo-López, Natalia, Naves-Díaz, Manuel, Anguita-Velasco, Javier, Cannata-Andía, Jorge B

“…This study aimed to test the viability and functionality of fresh and cryopreserved human hyperplastic parathyroid glands cultured in vitro. Small fragments of…”
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Effect of aluminium on calcium-sensing receptor expression, proliferation, and apoptosis of parathyroid glands from rats with chronic renal failure by González-Suárez, Ignacio, Naves, Manuel, Díaz-Corte, Carmen, Fernández-Martín, José L., Menéndez-Rodríguez, Primitiva, Cannata-Andía, Jorge B.

“…Effect of aluminium on calcium-sensing receptor expression, proliferation, and apoptosis of parathyroid glands from rats with chronic renal failure. To assess…”
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Molecular Basis of Parathyroid Hyperplasia by Dusso, Adriana S., PhD, Arcidiacono, Maria Vittoria, PhD, Sato, Tetsuhiko, MD, Alvarez-Hernandez, Daniel, PhD, Yang, Jing, BS, Gonzalez-Suarez, Ignacio, PhD, Tominaga, Yoshihiro, MD, Slatopolsky, Eduardo, MD

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In Vitro Systems Toxicology Assessment of a Candidate Modified Risk Tobacco Product Shows Reduced Toxicity Compared to That of a Conventional Cigarette by Gonzalez-Suarez, Ignacio, Martin, Florian, Marescotti, Diego, Guedj, Emmanuel, Acali, Stefano, Johne, Stephanie, Dulize, Remi, Baumer, Karine, Peric, Dariusz, Goedertier, Didier, Frentzel, Stefan, Ivanov, Nikolai V, Mathis, Carole, Hoeng, Julia, Peitsch, Manuel C

“…Cigarette smoke increases the risk for respiratory and other diseases. Although smoking prevalence has declined over the years, millions of adults choose to…”
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GladiaTOX: GLobal Assessment of Dose-IndicAtor in TOXicology by Belcastro, Vincenzo, Cano, Stephane, Marescotti, Diego, Acali, Stefano, Poussin, Carine, Gonzalez-Suarez, Ignacio, Martin, Florian, Bonjour, Filipe, Ivanov, Nikolai V, Peitsch, Manuel C, Hoeng, Julia

“…Abstract Summary GladiaTOX R package is an open-source, flexible solution to high-content screening data processing and reporting in biomedical research…”
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Telomere recombination requires the MUS81 endonuclease by Zeng, Sicong, Harris, Curtis C, Gonzalo, Susana, Gonzalez-Suarez, Ignacio, Yang, Qin, Xiang, Tao, Pandita, Tej K

“…Telomerase-negative cancer cells maintain their telomeres through the alternative lengthening of telomeres (ALT) pathway. Although a growing body of evidence…”
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