Search Results - "Su, Trent"

Promoter-Enhancer Communication Occurs Primarily within Insulated Neighborhoods by Sun, Fei, Chronis, Constantinos, Kronenberg, Michael, Chen, Xiao-Fen, Su, Trent, Lay, Fides D., Plath, Kathrin, Kurdistani, Siavash K., Carey, Michael F.

“…Metazoan chromosomes are sequentially partitioned into topologically associating domains (TADs) and then into smaller sub-domains. One class of sub-domains,…”
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Histone Acetylation Regulates Intracellular pH by McBrian, Matthew A., Behbahan, Iman Saramipoor, Ferrari, Roberto, Su, Trent, Huang, Ta-Wei, Li, Kunwu, Hong, Candice S., Christofk, Heather R., Vogelauer, Maria, Seligson, David B., Kurdistani, Siavash K.

“…Differences in global levels of histone acetylation occur in normal and cancer cells, although the reason why cells regulate these levels has been unclear…”
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Mot1, Ino80C, and NC2 Function Coordinately to Regulate Pervasive Transcription in Yeast and Mammals by Xue, Yong, Pradhan, Suman K., Sun, Fei, Chronis, Constantinos, Tran, Nancy, Su, Trent, Van, Christopher, Vashisht, Ajay, Wohlschlegel, James, Peterson, Craig L., Timmers, H.T. Marc, Kurdistani, Siavash K., Carey, Michael F.

“…Pervasive transcription initiates from cryptic promoters and is observed in eukaryotes ranging from yeast to mammals. The Set2-Rpd3 regulatory system prevents…”
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The Novel Omega-6 Fatty Acid Docosapentaenoic Acid Positively Modulates Brain Innate Immune Response for Resolving Neuroinflammation at Early and Late Stages of Humanized APOE-Based Alzheimer's Disease Models by Ma, Qiu-Lan, Zhu, Cansheng, Morselli, Marco, Su, Trent, Pelligrini, Matteo, Lu, Zhengqi, Jones, Mychica, Denver, Paul, Castro, Daniel, Gu, Xuelin, Relampagos, Frances, Caoili, Kaitlin, Teter, Bruce, Frautschy, Sally A, Cole, Gregory M

“…Neuroinflammation plays a crucial role in the development and progression of Alzheimer's disease (AD), in which activated microglia are found to be associated…”
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Discovery of potential serum protein biomarkers for lymph node metastasis in oral cancer by Chai, Yang D., Zhang, Lifeng, Yang, Yan, Su, Trent, Charugundla, Prashant, Ai, Jiye, Messadi, Diana, Wong, David T., Hu, Shen

“…ABSTRACT Background The purpose of our study was to identify serum protein biomarkers for node‐positive oral squamous cell carcinoma (OSCC). Biomarkers…”
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MEF2C protects bone marrow B-lymphoid progenitors during stress haematopoiesis by Wang, Wenyuan, Org, Tonis, Montel-Hagen, Amélie, Pioli, Peter D., Duan, Dan, Israely, Edo, Malkin, Daniel, Su, Trent, Flach, Johanna, Kurdistani, Siavash K., Schiestl, Robert H., Mikkola, Hanna K. A.

“…DNA double strand break (DSB) repair is critical for generation of B-cell receptors, which are pre-requisite for B-cell progenitor survival. However, the…”
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PRB1 is required for clipping of the histone H3 N terminal tail in Saccharomyces cerevisiae by Xue, Yong, Vashisht, Ajay A, Tan, Yuliang, Su, Trent, Wohlschlegel, James A

“…Cathepsin L, a lysosomal protein in mouse embryonic stem cells has been shown to clip the histone H3 N- terminus, an activity associated with gene activity…”
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Comparative transcriptomics reveals highly conserved regional programs between porcine and human colonic enteric nervous system by Li, Tao, Morselli, Marco, Su, Trent, Million, Mulugeta, Larauche, Muriel, Pellegrini, Matteo, Taché, Yvette, Yuan, Pu-Qing

“…The porcine gut is increasingly regarded as a useful translational model. The enteric nervous system in the colon coordinates diverse functions. However,…”
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A Forward Genetic Screen Targeting the Endothelium Reveals a Regulatory Role for the Lipid Kinase Pi4ka in Myelo- and Erythropoiesis by Ziyad, Safiyyah, Riordan, Jesse D., Cavanaugh, Ann M., Su, Trent, Hernandez, Gloria E., Hilfenhaus, Georg, Morselli, Marco, Huynh, Kristine, Wang, Kevin, Chen, Jau-Nian, Dupuy, Adam J., Iruela-Arispe, M. Luisa

“…Given its role as the source of definitive hematopoietic cells, we sought to determine whether mutations initiated in the hemogenic endothelium would yield…”
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Genome-wide binding map of the HIV-1 Tat protein to the human genome by Marban, Céline, Su, Trent, Ferrari, Roberto, Li, Bing, Vatakis, Dimitrios, Pellegrini, Matteo, Zack, Jerome A, Rohr, Olivier, Kurdistani, Siavash K

“…The HIV-1 Trans-Activator of Transcription (Tat) protein binds to multiple host cellular factors and greatly enhances the level of transcription of the HIV…”
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Loss of KDM4B exacerbates bone-fat imbalance and mesenchymal stromal cell exhaustion in skeletal aging by Deng, Peng, Yuan, Quan, Cheng, Yingduan, Li, Jiong, Liu, Zhenqing, Liu, Yan, Li, Ye, Su, Trent, Wang, Jing, Salvo, Mari Ekimyan, Wang, Weiguang, Fan, Guoping, Lyons, Karen, Yu, Bo, Wang, Cun-Yu

“…Skeletal aging is a complex process, characterized by a decrease in bone formation, an increase in marrow fat, and stem cell exhaustion. Loss of H3K9me3, a…”
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Meta-Tyrosine Induces Cytotoxic Misregulation of Metabolism in Escherichia coli by Howitz, Nathaniel, Su, Trent, Lazazzera, Beth A.

“…[Display omitted] •This study identified molecular responses of E. coli to m-Tyr, a toxic amino acid.•m-Tyr induced an unfolded-protein response and form…”
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EP400 Deposits H3.3 into Promoters and Enhancers during Gene Activation by Pradhan, Suman K., Su, Trent, Yen, Linda, Jacquet, Karine, Huang, Chengyang, Côté, Jacques, Kurdistani, Siavash K., Carey, Michael F.

“…Gene activation in metazoans is accompanied by the presence of histone variants H2AZ and H3.3 within promoters and enhancers. It is not known, however, what…”
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NOTCH1 is a mechanosensor in adult arteries by Mack, Julia J., Mosqueiro, Thiago S., Archer, Brian J., Jones, William M., Sunshine, Hannah, Faas, Guido C., Briot, Anais, Aragón, Raquel L., Su, Trent, Romay, Milagros C., McDonald, Austin I., Kuo, Cheng-Hsiang, Lizama, Carlos O., Lane, Timothy F., Zovein, Ann C., Fang, Yun, Tarling, Elizabeth J., de Aguiar Vallim, Thomas Q., Navab, Mohamad, Fogelman, Alan M., Bouchard, Louis S., Iruela-Arispe, M. Luisa

“…Endothelial cells transduce mechanical forces from blood flow into intracellular signals required for vascular homeostasis. Here we show that endothelial…”
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Histone H3 N-terminal acetylation sites especially K14 are important for rDNA silencing and aging by Xu, Heng-hao, Su, Trent, Xue, Yong

“…Histone variants and histone modifications are essential components in the establishment and maintenance of the repressed status of heterochromatin. Among…”
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Dysregulation of hsa-miR-34a and hsa-miR-449a leads to overexpression of PACS-1 and loss of DNA damage response (DDR) in cervical cancer by Veena, Mysore S., Raychaudhuri, Santanu, Basak, Saroj K., Venkatesan, Natarajan, Kumar, Parameet, Biswas, Roopa, Chakrabarti, Rita, Lu, Jing, Su, Trent, Gallagher-Jones, Marcus, Morselli, Marco, Fu, Haiqing, Pellegrini, Matteo, Goldstein, Theodore, Aladjem, Mirit I., Rettig, Matthew B., Wilczynski, Sharon P., Shin, Daniel Sanghoon, Srivatsan, Eri S.

“…We have observed overexpression of PACS-1, a cytosolic sorting protein in primary cervical tumors. Absence of exonic mutations and overexpression at the RNA…”
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Adenovirus Small E1A Employs the Lysine Acetylases p300/CBP and Tumor Suppressor Rb to Repress Select Host Genes and Promote Productive Virus Infection by Ferrari, Roberto, Gou, Dawei, Jawdekar, Gauri, Johnson, Sarah A., Nava, Miguel, Su, Trent, Yousef, Ahmed F., Zemke, Nathan R., Pellegrini, Matteo, Kurdistani, Siavash K., Berk, Arnold J.

“…Oncogenic transformation by adenovirus small e1a depends on simultaneous interactions with the host lysine acetylases p300/CBP and the tumor suppressor RB. How…”
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Reorganization of the host epigenome by a viral oncogene by Ferrari, Roberto, Su, Trent, Li, Bing, Bonora, Giancarlo, Oberai, Amit, Chan, Yvonne, Sasidharan, Rajkumar, Berk, Arnold J, Pellegrini, Matteo, Kurdistani, Siavash K

“…Adenovirus small e1a oncoprotein causes ~70% reduction in cellular levels of histone H3 lysine 18 acetylation (H3K18ac). It is unclear, however, where this…”
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Cbx3 maintains lineage specificity during neural differentiation by Huang, Chengyang, Su, Trent, Xue, Yong, Cheng, Chen, Lay, Fides D, McKee, Robin A, Li, Meiyang, Vashisht, Ajay, Wohlschlegel, James, Novitch, Bennett G, Plath, Kathrin, Kurdistani, Siavash K, Carey, Michael

“…Chromobox homolog 3 (Cbx3/heterochromatin protein 1γ [HP1γ]) stimulates cell differentiation, but its mechanism is unknown. We found that Cbx3 binds to gene…”
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Chromatin Remodeler EP400 Deposits H3.3 into Promoters and Enhancers During Gene Activation by Pradhan, Suman Kalyan, Su, Trent, Yen, Linda, Jacquet, Karine, Cote, Jacques, Kurdistani, Siavash, Carey, Michael

“…Abstract only Increasing evidence indicates that gene activation in metazoans is accompanied by deposition of the histone variants H2AZ and H3.3 into promoters…”
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