Search Results - "Su, Shinsan M"

Proto-Oncogenic Role of Mutant IDH2 in Leukemia Initiation and Maintenance by Kats, Lev M., Reschke, Markus, Taulli, Riccardo, Pozdnyakova, Olga, Burgess, Kerri, Bhargava, Parul, Straley, Kimberly, Karnik, Rahul, Meissner, Alexander, Small, Donald, Su, Shinsan M., Yen, Katharine, Zhang, Jiangwen, Pandolfi, Pier Paolo

“…Mutations in the metabolic enzymes isocitrate dehydrogenase-1 (IDH1) and IDH2 that produce the oncometabolite D-2-hydroxyglutarate (2-HG) occur frequently in…”
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An Inhibitor of Mutant IDH1 Delays Growth and Promotes Differentiation of Glioma Cells by Rohle, Dan, Popovici-Muller, Janeta, Palaskas, Nicolaos, Turcan, Sevin, Grommes, Christian, Campos, Carl, Tsoi, Jennifer, Clark, Owen, Oldrini, Barbara, Komisopoulou, Evangelia, Kunii, Kaiko, Pedraza, Alicia, Schalm, Stefanie, Silverman, Lee, Miller, Alexandra, Wang, Fang, Yang, Hua, Chen, Yue, Kernytsky, Andrew, Rosenblum, Marc K., Liu, Wei, Biller, Scott A., Su, Shinsan M., Brennan, Cameron W., Chan, Timothy A., Graeber, Thomas G., Yen, Katharine E., Mellinghoff, Ingo K.

“…The recent discovery of mutations in metabolic enzymes has rekindled interest in harnessing the altered metabolism of cancer cells for cancer therapy. One…”
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Cancer-associated IDH1 mutations produce 2-hydroxyglutarate by Bittinger, Mark A, Driggers, Edward M, Ward, Patrick S, Gross, Stefan, Su, Shinsan M, Liau, Linda M, Dang, Lenny, Fantin, Valeria R, Jang, Hyun Gyung, Marks, Kevin M, White, David W, Vander Heiden, Matthew G, Thompson, Craig B, Rabinowitz, Joshua D, Cantley, Lewis C, Keenan, Marie C, Prins, Robert M, Jin, Shengfang, Bennett, Bryson D, Yen, Katharine E

“…Mutations in the enzyme cytosolic isocitrate dehydrogenase 1 (IDH1) are a common feature of a major subset of primary human brain cancers. These mutations…”
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D-2-hydroxyglutarate produced by mutant IDH1 perturbs collagen maturation and basement membrane function by Sasaki, Masato, Knobbe, Christiane B, Itsumi, Momoe, Elia, Andrew J, Harris, Isaac S, Chio, Iok In Christine, Cairns, Rob A, McCracken, Susan, Wakeham, Andrew, Haight, Jillian, Ten, Annick You, Snow, Bryan, Ueda, Takeshi, Inoue, Satoshi, Yamamoto, Kazuo, Ko, Myunggon, Rao, Anjana, Yen, Katharine E, Su, Shinsan M, Mak, Tak Wah

“…Isocitrate dehydrogenase-1 (IDH1) R132 mutations occur in glioma, but their physiological significance is unknown. Here we describe the generation and…”
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IDH2 mutation-induced histone and DNA hypermethylation is progressively reversed by small-molecule inhibition by Kernytsky, Andrew, Wang, Fang, Hansen, Erica, Schalm, Stefanie, Straley, Kimberly, Gliser, Camelia, Yang, Hua, Travins, Jeremy, Murray, Stuart, Dorsch, Marion, Agresta, Sam, Schenkein, David P., Biller, Scott A., Su, Shinsan M., Liu, Wei, Yen, Katharine E.

“…Mutations of IDH1 and IDH2, which produce the oncometabolite 2-hydroxyglutarate (2HG), have been identified in several tumors, including acute myeloid…”
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Cancer-associated IDH1 mutations produce 2-hydroxyglutarate by Marks, Kevin M, Rabinowitz, Joshua D, Dang, Lenny, Gross, Stefan, Fantin, Valeria R, Keenan, Marie C, Driggers, Edward M, Bennett, Bryson D, Jang, Hyun Gyung, Liau, Linda M, Ward, Patrick S, Jin, Shengfang, Yen, Katharine E, Su, Shinsan M, Prins, Robert M, Vander Heiden, Matthew G, White, David W, Cantley, Lewis C, Thompson, Craig B, Bittinger, Mark A

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Non-invasive detection of 2-hydroxyglutarate and other metabolites in IDH1 mutant glioma patients using magnetic resonance spectroscopy by Pope, Whitney B., Prins, Robert M., Albert Thomas, M., Nagarajan, Rajakumar, Yen, Katharine E., Bittinger, Mark A., Salamon, Noriko, Chou, Arthur P., Yong, William H., Soto, Horacio, Wilson, Neil, Driggers, Edward, Jang, Hyun G., Su, Shinsan M., Schenkein, David P., Lai, Albert, Cloughesy, Timothy F., Kornblum, Harley I., Wu, Hong, Fantin, Valeria R., Liau, Linda M.

“…Mutations of the isocitrate dehydrogenase 1 and 2 genes ( IDH1 and IDH2 ) are commonly found in primary brain cancers. We previously reported that a novel…”
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ALDH2(E487K) mutation increases protein turnover and promotes murine hepatocarcinogenesis by Jin, Shengfang, Jiang Chen, Lizao Chen, Gavin Histen, Zhizhong Lin, Stefan Gross, Jeffrey Hixon, Yue Chen, Charles Kung, Yiwei Chen, Yufei Fu, Yuxuan Lu, Hui Lin, Xiujun Cai, Hua Yang, Rob A. Cairns, Marion Dorsch, Shinsan M. Su, Scott Biller, Tak W. Mak, Yong Cang

“…Mitochondrial aldehyde dehydrogenase 2 (ALDH2) in the liver removes toxic aldehydes including acetaldehyde, an intermediate of ethanol metabolism. Nearly 40%…”
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IDH1(R132H) mutation increases murine haematopoietic progenitors and alters epigenetics by Sasaki, Masato, Knobbe, Christiane B., Munger, Joshua C., Lind, Evan F., Brenner, Dirk, Brüstle, Anne, Harris, Isaac S., Holmes, Roxanne, Wakeham, Andrew, Haight, Jillian, You-Ten, Annick, Li, Wanda Y., Schalm, Stefanie, Su, Shinsan M., Virtanen, Carl, Reifenberger, Guido, Ohashi, Pamela S., Barber, Dwayne L., Figueroa, Maria E., Melnick, Ari, Zúñiga-Pflücker, Juan-Carlos, Mak, Tak W.

“…Mutations in isocitrate dehydrogenases IDH1 and IDH2 are common in human gliomas and acute myeloid leukaemias; here, mice that carry the IDH1(R132H) mutation…”
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IDH mutations in glioma and acute myeloid leukemia by Dang, Lenny, Jin, Shengfang, Su, Shinsan M

“…The systematic sequencing of glioblastoma multiforme (GBM) genomes has identified the recurrent mutation of IDH1, a gene encoding NADP+ -dependent isocitrate…”
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Cancer-associated metabolite 2-hydroxyglutarate accumulates in acute myelogenous leukemia with isocitrate dehydrogenase 1 and 2 mutations by Gross, Stefan, Cairns, Rob A, Minden, Mark D, Driggers, Edward M, Bittinger, Mark A, Jang, Hyun Gyung, Sasaki, Masato, Jin, Shengfang, Schenkein, David P, Su, Shinsan M, Dang, Lenny, Fantin, Valeria R, Mak, Tak W

“…Mutations in isocitrate dehydrogenase 1 and 2 (IDH1/2), are present in most gliomas and secondary glioblastomas, but are rare in other neoplasms. IDH1/2…”
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The Common Feature of Leukemia-Associated IDH1 and IDH2 Mutations Is a Neomorphic Enzyme Activity Converting α-Ketoglutarate to 2-Hydroxyglutarate by Ward, Patrick S., Patel, Jay, Wise, David R., Abdel-Wahab, Omar, Bennett, Bryson D., Coller, Hilary A., Cross, Justin R., Fantin, Valeria R., Hedvat, Cyrus V., Perl, Alexander E., Rabinowitz, Joshua D., Carroll, Martin, Su, Shinsan M., Sharp, Kim A., Levine, Ross L., Thompson, Craig B.

“…The somatic mutations in cytosolic isocitrate dehydrogenase 1 (IDH1) observed in gliomas can lead to the production of 2-hydroxyglutarate (2HG). Here, we…”
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Targeted Inhibition of Mutant IDH2 in Leukemia Cells Induces Cellular Differentiation by Wang, Fang, Travins, Jeremy, DeLaBarre, Byron, Penard-Lacronique, Virginie, Schalm, Stefanie, Hansen, Erica, Straley, Kimberly, Kernytsky, Andrew, Liu, Wei, Gliser, Camelia, Yang, Hua, Gross, Stefan, Artin, Erin, Saada, Veronique, Mylonas, Elena, Quivoron, Cyril, Popovici-Muller, Janeta, Saunders, Jeffrey O., Salituro, Francesco G., Yan, Shunqi, Murray, Stuart, Wei, Wentao, Gao, Yi, Dang, Lenny, Dorsch, Marion, Agresta, Sam, Schenkein, David P., Biller, Scott A., Su, Shinsan M., de Botton, Stephane, Yen, Katharine E.

“…A number of human cancers harbor somatic point mutations in the genes encoding isocitrate dehydrogenases 1 and 2 (IDH1 and IDH2). These mutations alter…”
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Discovery of the First Potent Inhibitors of Mutant IDH1 That Lower Tumor 2‑HG in Vivo by Popovici-Muller, Janeta, Saunders, Jeffrey O, Salituro, Francesco G, Travins, Jeremy M, Yan, Shunqi, Zhao, Fang, Gross, Stefan, Dang, Lenny, Yen, Katharine E, Yang, Hua, Straley, Kimberly S, Jin, Shengfang, Kunii, Kaiko, Fantin, Valeria R, Zhang, Shunan, Pan, Qiongqun, Shi, Derek, Biller, Scott A, Su, Shinsan M

“…Optimization of a series of R132H IDH1 inhibitors from a high throughput screen led to the first potent molecules that show robust tumor 2-HG inhibition in a…”
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Small Molecule Activation of PKM2 in Cancer Cells Induces Serine Auxotrophy by Kung, Charles, Hixon, Jeff, Choe, Sung, Marks, Kevin, Gross, Stefan, Murphy, Erin, DeLaBarre, Byron, Cianchetta, Giovanni, Sethumadhavan, Shalini, Wang, Xiling, Yan, Shunqi, Gao, Yi, Fang, Cheng, Wei, Wentao, Jiang, Fan, Wang, Shaohui, Qian, Kevin, Saunders, Jeff, Driggers, Ed, Woo, Hin Koon, Kunii, Kaiko, Murray, Stuart, Yang, Hua, Yen, Katharine, Liu, Wei, Cantley, Lewis C., Vander Heiden, Matthew G., Su, Shinsan M., Jin, Shengfang, Salituro, Francesco G., Dang, Lenny

“…Proliferating tumor cells use aerobic glycolysis to support their high metabolic demands. Paradoxically, increased glycolysis is often accompanied by…”
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Abstract B126: AG-881, a brain penetrant, potent, pan-mutant IDH (mIDH) inhibitor for use in mIDH solid and hematologic malignancies by Yen, Katharine, Konteatis, Zenon, Sui, Zhihua, Artin, Erin, Dang, Lenny, Straley, Kimberly, Tobin, Erica, Campos, Carl, Yang, Hua, Nagaraja, Raj, Chen, Yue, Kim, Hyeryun, Gliser, Camelia, Nicolay, Brandon, Olaharski, Andrew, Silverman, Lee, Biller, Scott, Su, Shinsan M., Mellinghoff, Ingo, Popovici-Muller, Janeta

“…Abstract AG-881 is an orally available, brain penetrant, potent, small-molecule inhibitor of isocitrate dehydrogenase (IDH) 1 and IDH2 mutant proteins…”
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Abstract 2296: IDH2 mutation induced histone and DNA hypermethylation is progressively reversed by small molecule inhibition by Kernytsky, Andrew, Wang, Fang, Hansen, Erica, Schalm, Stefanie, Straley, Kimberly, Gliser, Camelia, Yang, Hua, Travins, Jeremy, Murray, Stuart, Dorsch, Marion, Agresta, Sam, Schenkein, David P., Biller, Scott A., Su, Shinsan M., Liu, Wei, Yen, Katharine E.

“…Abstract Mutations of IDH1 and IDH2 which produce the oncometabolite 2-hydroxyglutarate (2HG), have been identified in several tumors including acute myeloid…”
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Abstract 5452: Cancer-associated metabolite 2-hydroxyglutarate accumulates in AML with IDH1/2 mutations by Fantin, Valeria R., Gross, Stefan, Cairns, Rob A., Minden, Mark D., Driggers, Edward M., Jang, Hyun Gyung, Sasaki, Masato, Jin, Shengfang, Schenkein, David P., Su, Shinsan M., Dang, Lenny, Mak, Tak W.

“…Abstract Mutations in isocitrate dehydrogenase 1 and 2 (IDH1/2), are present in most gliomas and secondary glioblastomas, but are rare in other neoplasms…”
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Abstract 33: Cancer-associated IDH1 mutations produce 2-hydroxyglutarate by Fantin, Valeria R., Dang, Lenny, White, David W., Gross, Stefan, Bittinger, Mark A., Driggers, Edward M., Jang, Hyun Gyung, Jin, Shengfang, Keenan, Marie C., Marks, Kevin M., Yen, Katharine E., Ward, Patrick S., Prins, Robert M., Liau, Linda M., Bennett, Bryson D., Rabinowitz, Joshua D., Cantley, Lewis C., Thompson, Craig B., Heiden, Matthew Vander, Su, Shinsan M.

“…Abstract Mutations in the enzyme isocitrate dehydrogenase 1 (IDH1) are a common feature of most gliomas and secondary glioblastomas, as well as approx 10%…”
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The Common Feature of Leukemia-Associated IDH1 and IDH2 Mutations Is a Neomorphic Enzyme Activity Converting a-Ketoglutarate to 2-Hydroxyglutarate by Ward, Patrick S, Patel, Jay, Wise, David R, Abdel-Wahab, Omar, Bennett, Bryson D, Coller, Hilary A, Cross, Justin R, Fantin, Valeria R, Hedvat, Cyrus V, Perl, Alexander E, Rabinowitz, Joshua D, Carroll, Martin, Su, Shinsan M, Sharp, Kim A, Levine, Ross L, Thompson, Craig B

“…The somatic mutations in cytosolic isocitrate dehydrogenase 1 (IDH1) observed in gliomas can lead to the production of 2-hydroxyglutarate (2HG). Here, we…”
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