Search Results - "Su, Jack M. F."

Maximizing the potential of aggressive mouse tumor models in preclinical drug testing by Elghetany, M. Tarek, Ho, Jia-Min, Shi-Qi, Lois Hew, Karthik, Sekar, Su, Jack M. F., Lin, Qi, Du, YuChen, Shen, Jianhe, Chow, Wing-Yuk, Lau, Ching C., Adesina, Adekunle, Major, Angela, Erdreich-Epstein, Anat, Hui, Kam-Man, Li, Xiao-Nan, Teo, Wan-Yee

“…Atypical teratoid rhabdoid tumor (ATRT) is an aggressive embryonal brain tumor among infants and young children. Two challenges exist for preclinical testing…”
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Publisher Correction: Epigenetic alterations of repeated relapses in patient-matched childhood ependymomas by Zhao, Sibo, Li, Jia, Zhang, Huiyuan, Qi, Lin, Du, Yuchen, Kogiso, Mari, Braun, Frank K., Xiao, Sophie, Huang, Yulun, Li, Jianfang, Teo, Wan-Yee, Lindsay, Holly, Baxter, Patricia, Su, Jack M. F., Adesina, Adekunle, Laczik, Miklós, Genevini, Paola, Veillard, Anne-Clemence, Schvartzman, Sol, Berguet, Geoffrey, Ding, Shi-Rong, Du, Liping, Stephan, Clifford, Yang, Jianhua, Davies, Peter J. A., Lu, Xinyan, Chintagumpala, Murali, Parsons, Donald William, Perlaky, Laszlo, Xia, Yun-Fei, Man, Tsz-Kwong, Huang, Yun, Sun, Deqiang, Li, Xiao-Nan

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Epigenetic Alterations of Repeated Relapses in Patient-matched Childhood Ependymomas by Zhao, Sibo, Li, Jia, Zhang, Huiyuan, Qi, Lin, Du, Yuchen, Kogiso, Mari, Braun, Frank K., Xiao, Sophie, Huang, Yulun, Li, Jianfang, Teo, Wan-Yee, Lindsay, Holly, Baxter, Patricia, Su, Jack M. F., Adesina, Adekunle, Laczik, Miklós, Genevini, Paola, Veillard, Anne-Clemence, Schvartzman, Sol, Berguet, Geoffrey, Ding, Shi-Rong, Du, Liping, Stephan, Clifford, Yang, Jianhua, Davies, Peter J. A., Lu, Xinyan, Chintagumpala, Murali, Parsons, Donald William, Perlaky, Laszlo, Xia, Yun-Fei, Man, Tsz-Kwong, Huang, Yun, Sun, Deqiang, Li, Xiao-Nan

“…Recurrence is frequent in pediatric ependymoma (EPN). Our longitudinal integrated analysis of 30 patient-matched repeated relapses (3.67 ± 1.76 times) over 13…”
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Spatial Dissection of Invasive Front from Tumor Mass Enables Discovery of Novel microRNA Drivers of Glioblastoma Invasion by Huang, Yulun, Qi, Lin, Kogiso, Mari, Du, Yuchen, Braun, Frank K., Zhang, Huiyuan, Huang, L. Frank, Xiao, Sophie, Teo, Wan‐Yee, Lindsay, Holly, Zhao, Sibo, Baxter, Patricia, Su, Jack M. F., Adesina, Adekunle, Yang, Jianhua, Brabetz, Sebastian, Kool, Marcel, Pfister, Stefan M., Chintagumpala, Murali, Perlaky, Laszlo, Wang, Zhong, Zhou, Youxin, Man, Tsz‐Kwong, Li, Xiao‐Nan

“…Diffuse invasion is the primary cause of treatment failure of glioblastoma (GBM). Previous studies on GBM invasion have long been forced to use the resected…”
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Fractionated radiation therapy alters energy metabolism and induces cellular quiescence exit in patient-derived orthotopic xenograft models of high-grade glioma by Huang, Zi-Lu, Liu, Zhi-Gang, Lin, Qi, Tao, Ya-Lan, Li, Xinzhuoyun, Baxter, Patricia, Su, Jack MF, Adesina, Adekunle M., Man, Chris, Chintagumpala, Murali, Teo, Wan Yee, Du, Yu-Chen, Xia, Yun-Fei, Li, Xiao-Nan

“…•Applied clinically relavant fractionated radiation therapy in patient derived orthotopic xenograft (PDOX) mouse models of pediatric high grade glioma…”
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A single intravenous injection of oncolytic picornavirus SVV-001 eliminates medulloblastomas in primary tumor-based orthotopic xenograft mouse models by Yu, Litian, Baxter, Patricia A., Zhao, Xiumei, Liu, Zhigang, Wadhwa, Lalita, Zhang, Yujing, Su, Jack MF, Tan, Xiaojie, Yang, Jianhua, Adesina, Adekunle, Perlaky, Lazlo, Hurwitz, Mary, Idamakanti, Neeraja, Police, Seshidhar Reddy, Hallenbeck, Paul L., Blaney, Susan M., Chintagumpala, Murali, Hurwitz, Richard L., Li, Xiao-Nan

“…Difficulties of drug delivery across the blood-brain barrier (BBB) and failure to eliminate cancer stem cells (CSCs) are believed to be the major causes of…”
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CD57 defines a novel cancer stem cell that drive invasion of diffuse pediatric-type high grade gliomas by Qi, Lin, Du, Yuchen, Huang, Yulun, Kogiso, Mari, Zhang, Huiyuan, Xiao, Sophie, Abdallah, Aalaa, Suarez, Milagros, Niu, Long, Liu, Zhi-gang, Lindsay, Holly, Braun, Frank K., Stephen, Clifford, Davies, Peter J., Teo, Wan Yee, Adenkunle, Adesina, Baxter, Patricia, Su, Jack MF, Li, Xiao-Nan

“…Background Diffuse invasion remains a primary cause of treatment failure in pediatric high-grade glioma (pHGG). Identifying cellular driver(s) of pHGG invasion…”
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Re-programming by a six-factor-secretome in the patient tumor ecosystem during nutrient stress and drug response by Elghetany, M. Tarek, Pan, Jie-Ling, Sekar, Karthik, Major, Angela, MF Su, Jack, Adesina, Adekunle, Hui, Kam-Man, Li, Xiao-Nan, Teo, Wan-Yee

“…Cancer cells need nutrients to grow and proliferate. During nutrient stress in the microenvironment, it is unclear if or how cancer cells can adopt alternative…”
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Impact of SCID mouse gender on tumorigenicity, xenograft growth and drug-response in a large panel of orthotopic PDX models of pediatric brain tumors by Qi, Lin, Kogiso, Mari, Du, Yuchen, Zhang, Huiyuan, Braun, Frank K., Huang, Yulun, Teo, Wan-Yee, Lindsay, Holly, Zhao, Sibo, Baxter, Patricia, Zhao, Xiumei, Yu, Litian, Liu, Zhigang, Zhang, Xingding, Su, Jack MF, Adesina, Adekunle, Yang, Jianhua, Chintagumpala, Murali, Perlaky, Laszlo, Tsz-Kwong Man, Chris, Lau, Ching C., Li, Xiao-Nan

“…Brain tumor is the leading cause of cancer related death in children. Clinically relevant animals are critical for new therapy development. To address the…”
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Evaluation of an EZH2 inhibitor in patient-derived orthotopic xenograft models of pediatric brain tumors alone and in combination with chemo- and radiation therapies by Qi, Lin, Lindsay, Holly, Kogiso, Mari, Du, Yuchen, Braun, Frank K., Zhang, Huiyuan, Guo, Lei, Zhao, Sibo, Injac, Sarah G., Baxter, Patricia A., Su, Jack MF, Xiao, Sophie, Erickson, Stephen W., Earley, Eric J., Teicher, Beverly, Smith, Malcolm A., Li, Xiao-Nan

“…Brain tumors are the leading cause of cancer-related death in children. Tazemetostat is an FDA-approved enhancer of zeste homolog (EZH2) inhibitor. To…”
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MEDB-08. Inhibition of different mitotic targets demonstrated distinct DNA damage and cell death response in p53-mutant medulloblastoma by Huang, Shiying, Pan, Jie-Ling, Karthik, Sekar, Du, YuChen, Lin, Qi, Lau, Ching C, Adekunle, Adesina, Su, Jack M F, Major, Angela, Elghetany, M Tarek, Hui, Kam-Man, Li, Xiaonan, Teo, Wan-Yee

“…Abstract BACKGROUND: In normal cells, cell cycle is tightly regulated by mitotic proteins to ensure smooth transition through each phase of cell division…”
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EMBR-23. KIF11 DEPENDENCY ON P53 MUTATIONAL STATUS IN MEDULLOBLASTOMA by Huang, Shiying, Karthik, Sekar, Lin, Qi, Du, YuChen, Lau, Ching C, Adekunle, Adesina, Su, Jack M F, Major, Angela, Elghetany, M Tarek, Hui, Kam-Man, Li, Xiaonan, Teo, Wan-Yee

“…Abstract Introduction KIF11, a mitotic kinesin, is a component responsible for assembly and maintenance of mitotic spindle during mitosis. Tumor cells can…”
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MODL-29. Molecular Landscape of a comprehensive panel of pediatric brain cancer Patient-derived orthotopic xenograft (PDOX) models inform unique targets for drug responsiveness by Braun, Frank K, Brabetz, Sebastian, Qi, Lin, Du, Yuchen, Kogiso, Mari, Zhang, Hui Yuan, Linday, Holly, Teo, Wanyee, Baxter, Patricia, Su, Jack M F, Adekunle, Adesina, Goeun, Bae, Powell, Reid T, Parsons, Donald W, Chintagumpala, Murali, Stephan, Clifford C, Pfister, Stefan, Lau, Ching C, Kool, Marcel, Li, Xiao-Nan

“…Abstract Brain tumor is a leading cause of cancer related death in children. In addition to replicating histopathology, animal models faithfully replicating…”
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MEDU-07. A PILOT EXPLORATORY STUDY ON THE ROLE OF A SUBPOPULATION OF MACROPHAGES IN MEDULLOBLASTOMA by Yap, Aixin, Elghetany, M Tarek, Major, Angela, Su, Jack MF, Li, Xiaonan, Hui, Kam Man, Teo, Wan-Yee

“…Medulloblastoma (MB) is the most common childhood malignant brain tumor. We have previously described the presence of tumor-infiltrating macrophages among…”
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Abstract 5113: Fractionated radiation therapy alters energy metabolism and induces cellular quiescence exit in patient-derived orthotopic xenograft models of high-grade glioma by Huang, Zi-Lu, Liu, Zhi-Gang, Lin, Qi, Tao, Ya-Lan, Li, Xinzhuoyun, Baxter, Patricia, Su, Jack MF, Adesina, Adekunle M., Man, Chris, Chintagumpala, Murali, Teo, Wan Yee, Du, Yu-Chen, Xia, Yun-Fei, Li, Xiao-Nan

“…Abstract Radiation is one of the standard therapies for pediatric high-grade glioma (pHGG), of which the prognosis remains poor. To gain an in-depth…”
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Abstract 1484: CD57 defines a novel maker of glioblastoma stem cells that have greater invasive potential than CD133+ tumor cells by Qi, Lin, Huang, Yu-lun, Kogiso, Mari, Mao, Hua, Baxter, Patricia, Su, Jack MF, Perlaky, Laszlo, Lau, Ching C., Chintagumpala, Murali, Li, Xiao-Nan

“…Abstract Glioblastoma multiforme (GBM) is the most aggressive and lethal brain tumor that occurs both in children and adults. Diffuse invasion into normal…”
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Abstract 3292: Therapeutic targeting of INI1 deficiency in pediatric ATRT: a preclinical study utilizing patient-derived orthotopic xenograft (PDOX) models by Lindsay, Holly B., Kogiso, Mari, Qi, Lin, Murray, Jeffrey C., Perlaky, Laszlo, Su, Jack MF, Baxter, Patricia, Adesina, Adekunle, Parsons, Donald W., Chintagumpala, Murali, Li, Xiao-Nan

“…Abstract Introduction: Atypical teratoid rhabdoid tumors (ATRTs) are a high grade pediatric brain malignancy with extremely poor survival outcomes. They are…”
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Abstract 1450: Autopsy derived orthotopic xenograft (ADOX) mouse models for terminal pediatric brain tumors by Qi, Lin, Patricia, Baxter A., Mari, Kogiso, Yuchen, Du, Holly, Lindsay, Zhigang, Liu, Zhao, Xiumei, Zhang, Yujing, Su, Jack MF, Adesina, Adekunle, Walter, Andrew W., Murray, Jeffery, McNall-Knapp, Rene, Nazarian, Javad, Parsons, Will, Chintagumpala, Murali, Blaney, Susan, Li, Xiao-Nan

“…Abstract Brain tumors are the leading cause of cancer related death in children, and there is biological differences between treatment naïve tumors and their…”
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