Search Results - "Su, Chinh Tran To"
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Perspective: The promises of a holistic view of proteins-impact on antibody engineering and drug discovery
Published in Bioscience reports (31-01-2019)“…The reductionist approach is prevalent in biomedical science. However, increasing evidence now shows that biological systems cannot be simply considered as the…”
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Role of the IgE variable heavy chain in FcεRIα and superantigen binding in allergy and immunotherapy
Published in Journal of allergy and clinical immunology (01-08-2019)“…Variable heavy chain (VH) family frameworks (FWRs) have been reported to affect antibody receptor and superantigen binding; however, such effects in IgE remain…”
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Reviewing HIV-1 Gag Mutations in Protease Inhibitors Resistance: Insights for Possible Novel Gag Inhibitor Designs
Published in Molecules (Basel, Switzerland) (06-09-2019)“…HIV protease inhibitors against the viral protease are often hampered by drug resistance mutations in protease and in the viral substrate Gag. To overcome this…”
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The Determination of HIV-1 RT Mutation Rate, Its Possible Allosteric Effects, and Its Implications on Drug Resistance
Published in Viruses (09-03-2020)“…The high mutation rate of the human immunodeficiency virus type 1 (HIV-1) plays a major role in treatment resistance, from the development of vaccines to…”
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Structural modelling of the lumenal domain of human GPAA1, the metallo-peptide synthetase subunit of the transamidase complex, reveals zinc-binding mode and two flaps surrounding the active site
Published in Biology direct (29-09-2020)“…The transamidase complex is a molecular machine in the endoplasmic reticulum of eukaryotes that attaches a glycosylphosphatidylinositol (GPI) lipid anchor to…”
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Targeting the GPI transamidase subunit GPAA1 abrogates the CD24 immune checkpoint in ovarian cancer
Published in Cell reports (Cambridge) (23-04-2024)“…CD24 is frequently overexpressed in ovarian cancer and promotes immune evasion by interacting with its receptor Siglec10, present on tumor-associated…”
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Molecular Insights of Nickel Binding to Therapeutic Antibodies as a Possible New Antibody Superantigen
Published in Frontiers in immunology (08-07-2021)“…The binding of nickel by immune proteins can manifest as Type IV contact dermatitis (Ni-specific T cells mediated) and less frequently as Type I…”
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Essentially Leading Antibody Production: An Investigation of Amino Acids, Myeloma, and Natural V-Region Signal Peptides in Producing Pertuzumab and Trastuzumab Variants
Published in Frontiers in immunology (07-12-2020)“…Boosting the production of recombinant therapeutic antibodies is crucial in both academic and industry settings. In this work, we investigated the usage of…”
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An Alternative HIV-1 Non-Nucleoside Reverse Transcriptase Inhibition Mechanism: Targeting the p51 Subunit
Published in Molecules (Basel, Switzerland) (13-12-2020)“…The ongoing development of drug resistance in HIV continues to push for the need of alternative drug targets in inhibiting HIV. One such target is the Reverse…”
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The role of Antibody Vκ Framework 3 region towards Antigen binding: Effects on recombinant production and Protein L binding
Published in Scientific reports (19-06-2017)“…Antibody research has traditionally focused on heavy chains, often neglecting the important complementary role of light chains in antibody formation and…”
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A computational study for rational HIV-1 non-nucleoside reverse transcriptase inhibitor selection and the discovery of novel allosteric pockets for inhibitor design
Published in Bioscience reports (27-04-2018)“…HIV drug resistant mutations that render the current Highly Active Anti-Retroviral Therapy (HAART) cocktail drugs ineffective are increasingly reported. To…”
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Allosteric Effects between the Antibody Constant and Variable Regions: A Study of IgA Fc Mutations on Antigen Binding
Published in Antibodies (Basel) (07-06-2018)“…Therapeutic antibodies have shifted the paradigm of disease treatments from small molecules to biologics, especially in cancer therapy. Despite the increasing…”
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IFACEwat: the interfacial water-implemented re-ranking algorithm to improve the discrimination of near native structures for protein rigid docking
Published in BMC bioinformatics (08-12-2014)“…Protein-protein docking is an in silico method to predict the formation of protein complexes. Due to limited computational resources, the protein-protein…”
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Variable-heavy (VH) families influencing IgA1&2 engagement to the antigen, FcαRI and superantigen proteins G, A, and L
Published in Scientific reports (20-04-2022)“…Interest in IgA as an alternative antibody format has increased over the years with much remaining to be investigated in relation to interactions with immune…”
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Structural analysis of the novel influenza A (H7N9) viral Neuraminidase interactions with current approved neuraminidase inhibitors Oseltamivir, Zanamivir, and Peramivir in the presence of mutation R289K
Published in BMC bioinformatics (22-10-2013)“…Since late March 2013, there has been another global health concern with a sudden wave of flu infections by a novel strain of avian influenza A (H7N9) virus in…”
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Structural analyses of 2015-updated drug-resistant mutations in HIV-1 protease: an implication of protease inhibitor cross-resistance
Published in BMC bioinformatics (22-12-2016)“…Strategies to control HIV for improving the quality of patient lives have been aided by the Highly Active Anti-Retroviral Therapy (HAART), which consists of a…”
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Modeling the full length HIV-1 Gag polyprotein reveals the role of its p6 subunit in viral maturation and the effect of non-cleavage site mutations in protease drug resistance
Published in Journal of biomolecular structure & dynamics (10-12-2018)“…HIV polyprotein Gag is increasingly found to contribute to protease inhibitor resistance. Despite its role in viral maturation and in developing drug…”
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Discovery of a novel splice variant of Fcar (CD89) unravels sequence segments necessary for efficient secretion: A story of bad signal peptides and good ones that nevertheless do not make it
Published in Cell cycle (Georgetown, Tex.) (04-03-2017)“…The IgA receptor, Fcar (CD89) consists of 5 sequence segments: 2 segments (S1, S2) forming the potential signal peptide, 2 extracellular EC domains that…”
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QuickVina: Accelerating AutoDock Vina Using Gradient-Based Heuristics for Global Optimization
Published in IEEE/ACM transactions on computational biology and bioinformatics (01-09-2012)“…Predicting binding between macromolecule and small molecule is a crucial phase in the field of rational drug design. AutoDock Vina, one of the most widely used…”
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CovalentDock: Automated covalent docking with parameterized covalent linkage energy estimation and molecular geometry constraints
Published in Journal of computational chemistry (05-02-2013)“…Covalent linkage formation is a very important mechanism for many covalent drugs to work. However, partly due to the limitations of proper computational tools…”
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