Search Results - "Su, Chinh Tran To"

Perspective: The promises of a holistic view of proteins-impact on antibody engineering and drug discovery by Phua, Ser-Xian, Chan, Kwok-Fong, Su, Chinh Tran-To, Poh, Jun-Jie, Gan, Samuel Ken-En

“…The reductionist approach is prevalent in biomedical science. However, increasing evidence now shows that biological systems cannot be simply considered as the…”
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Role of the IgE variable heavy chain in FcεRIα and superantigen binding in allergy and immunotherapy by Lua, Wai-Heng, Su, Chinh Tran-To, Yeo, Joshua Yi, Poh, Jun-Jie, Ling, Wei-Li, Phua, Ser-Xian, Gan, Samuel Ken-En

“…Variable heavy chain (VH) family frameworks (FWRs) have been reported to affect antibody receptor and superantigen binding; however, such effects in IgE remain…”
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Reviewing HIV-1 Gag Mutations in Protease Inhibitors Resistance: Insights for Possible Novel Gag Inhibitor Designs by Su, Chinh Tran-To, Koh, Darius Wen-Shuo, Gan, Samuel Ken-En

“…HIV protease inhibitors against the viral protease are often hampered by drug resistance mutations in protease and in the viral substrate Gag. To overcome this…”
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The Determination of HIV-1 RT Mutation Rate, Its Possible Allosteric Effects, and Its Implications on Drug Resistance by Yeo, Joshua Yi, Goh, Ghin-Ray, Su, Chinh Tran-To, Gan, Samuel Ken-En

“…The high mutation rate of the human immunodeficiency virus type 1 (HIV-1) plays a major role in treatment resistance, from the development of vaccines to…”
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Structural modelling of the lumenal domain of human GPAA1, the metallo-peptide synthetase subunit of the transamidase complex, reveals zinc-binding mode and two flaps surrounding the active site by Su, Chinh Tran-To, Sinha, Swati, Eisenhaber, Birgit, Eisenhaber, Frank

“…The transamidase complex is a molecular machine in the endoplasmic reticulum of eukaryotes that attaches a glycosylphosphatidylinositol (GPI) lipid anchor to…”
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Targeting the GPI transamidase subunit GPAA1 abrogates the CD24 immune checkpoint in ovarian cancer by Mishra, Alok K., Ye, Tianyi, Banday, Shahid, Thakare, Ritesh P., Su, Chinh Tran-To, Pham, Ngoc N.H., Ali, Amjad, Kulshreshtha, Ankur, Chowdhury, Shreya Roy, Simone, Tessa M., Hu, Kai, Zhu, Lihua Julie, Eisenhaber, Birgit, Deibler, Sara K., Simin, Karl, Thompson, Paul R., Kelliher, Michelle A., Eisenhaber, Frank, Malonia, Sunil K., Green, Michael R.

“…CD24 is frequently overexpressed in ovarian cancer and promotes immune evasion by interacting with its receptor Siglec10, present on tumor-associated…”
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Molecular Insights of Nickel Binding to Therapeutic Antibodies as a Possible New Antibody Superantigen by Su, Chinh Tran-To, Lua, Wai-Heng, Poh, Jun-Jie, Ling, Wei-Li, Yeo, Joshua Yi, Gan, Samuel Ken-En

“…The binding of nickel by immune proteins can manifest as Type IV contact dermatitis (Ni-specific T cells mediated) and less frequently as Type I…”
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Essentially Leading Antibody Production: An Investigation of Amino Acids, Myeloma, and Natural V-Region Signal Peptides in Producing Pertuzumab and Trastuzumab Variants by Ling, Wei-Li, Su, Chinh Tran-To, Lua, Wai-Heng, Poh, Jun-Jie, Ng, Yuen-Ling, Wipat, Anil, Gan, Samuel Ken-En

“…Boosting the production of recombinant therapeutic antibodies is crucial in both academic and industry settings. In this work, we investigated the usage of…”
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An Alternative HIV-1 Non-Nucleoside Reverse Transcriptase Inhibition Mechanism: Targeting the p51 Subunit by Chan, Kwok-Fong, Su, Chinh Tran-To, Krah, Alexander, Phua, Ser-Xian, Yeo, Joshua Yi, Ling, Wei-Li, Bond, Peter J, Gan, Samuel Ken-En

“…The ongoing development of drug resistance in HIV continues to push for the need of alternative drug targets in inhibiting HIV. One such target is the Reverse…”
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The role of Antibody Vκ Framework 3 region towards Antigen binding: Effects on recombinant production and Protein L binding by Su, Chinh Tran-To, Ling, Wei-Li, Lua, Wai-Heng, Poh, Jun-Jie, Gan, Samuel Ken-En

“…Antibody research has traditionally focused on heavy chains, often neglecting the important complementary role of light chains in antibody formation and…”
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A computational study for rational HIV-1 non-nucleoside reverse transcriptase inhibitor selection and the discovery of novel allosteric pockets for inhibitor design by Chiang, Ron Zhi-Hui, Gan, Samuel Ken-En, Su, Chinh Tran-To

“…HIV drug resistant mutations that render the current Highly Active Anti-Retroviral Therapy (HAART) cocktail drugs ineffective are increasingly reported. To…”
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Allosteric Effects between the Antibody Constant and Variable Regions: A Study of IgA Fc Mutations on Antigen Binding by Su, Chinh, Lua, Wai-Heng, Ling, Wei-Li, Gan, Samuel

“…Therapeutic antibodies have shifted the paradigm of disease treatments from small molecules to biologics, especially in cancer therapy. Despite the increasing…”
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IFACEwat: the interfacial water-implemented re-ranking algorithm to improve the discrimination of near native structures for protein rigid docking by Su, Chinh, Nguyen, Thuy-Diem, Zheng, Jie, Kwoh, Chee-Keong

“…Protein-protein docking is an in silico method to predict the formation of protein complexes. Due to limited computational resources, the protein-protein…”
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Variable-heavy (VH) families influencing IgA1&2 engagement to the antigen, FcαRI and superantigen proteins G, A, and L by Ling, Wei-Li, Su, Chinh Tran-To, Lua, Wai-Heng, Yeo, Joshua Yi, Poh, Jun-Jie, Ng, Yuen-Ling, Wipat, Anil, Gan, Samuel Ken-En

“…Interest in IgA as an alternative antibody format has increased over the years with much remaining to be investigated in relation to interactions with immune…”
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Structural analysis of the novel influenza A (H7N9) viral Neuraminidase interactions with current approved neuraminidase inhibitors Oseltamivir, Zanamivir, and Peramivir in the presence of mutation R289K by Tran-To Su, Chinh, Ouyang, Xuchang, Zheng, Jie, Kwoh, Chee-Keong

“…Since late March 2013, there has been another global health concern with a sudden wave of flu infections by a novel strain of avian influenza A (H7N9) virus in…”
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Structural analyses of 2015-updated drug-resistant mutations in HIV-1 protease: an implication of protease inhibitor cross-resistance by Su, Chinh Tran-To, Ling, Wei-Li, Lua, Wai-Heng, Haw, Yu-Xuan, Gan, Samuel Ken-En

“…Strategies to control HIV for improving the quality of patient lives have been aided by the Highly Active Anti-Retroviral Therapy (HAART), which consists of a…”
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Modeling the full length HIV-1 Gag polyprotein reveals the role of its p6 subunit in viral maturation and the effect of non-cleavage site mutations in protease drug resistance by Su, Chinh Tran-To, Kwoh, Chee-Keong, Verma, Chandra Shekhar, Gan, Samuel Ken-En

“…HIV polyprotein Gag is increasingly found to contribute to protease inhibitor resistance. Despite its role in viral maturation and in developing drug…”
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Discovery of a novel splice variant of Fcar (CD89) unravels sequence segments necessary for efficient secretion: A story of bad signal peptides and good ones that nevertheless do not make it by Lua, Wai-Heng, Ling, Wei-Li, Su, Chinh Tran-To, Yeo, Joshua Yi, Verma, Chandra Shekhar, Eisenhaber, Birgit, Eisenhaber, Frank, Gan, Samuel Ken-En

“…The IgA receptor, Fcar (CD89) consists of 5 sequence segments: 2 segments (S1, S2) forming the potential signal peptide, 2 extracellular EC domains that…”
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QuickVina: Accelerating AutoDock Vina Using Gradient-Based Heuristics for Global Optimization by Handoko, Stephanus Daniel, Xuchang Ouyang, Chinh Tran To Su, Chee Keong Kwoh, Yew Soon Ong

“…Predicting binding between macromolecule and small molecule is a crucial phase in the field of rational drug design. AutoDock Vina, one of the most widely used…”
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CovalentDock: Automated covalent docking with parameterized covalent linkage energy estimation and molecular geometry constraints by Ouyang, Xuchang, Zhou, Shuo, Su, Chinh Tran To, Ge, Zemei, Li, Runtao, Kwoh, Chee Keong

“…Covalent linkage formation is a very important mechanism for many covalent drugs to work. However, partly due to the limitations of proper computational tools…”
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