Search Results - "Stylos, Evgenios K."

Encapsulation of Temozolomide in a Calixarene Nanocapsule Improves Its Stability and Enhances Its Therapeutic Efficacy against Glioblastoma by Renziehausen, Alexander, Tsiailanis, Antonis D, Perryman, Richard, Stylos, Evgenios K, Chatzigiannis, Christos, O'Neill, Kevin, Crook, Timothy, Tzakos, Andreas G, Syed, Nelofer

“…The alkylating agent temozolomide (TMZ) is the first-line chemotherapeutic for glioblastoma (GBM), a common and aggressive primary brain tumor in adults…”
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Host–Guest Interactions between Candesartan and Its Prodrug Candesartan Cilexetil in Complex with 2‑Hydroxypropyl-β-cyclodextrin: On the Biological Potency for Angiotensin II Antagonism by Ntountaniotis, Dimitrios, Andreadelis, Ioannis, Kellici, Tahsin F, Karageorgos, Vlasios, Leonis, Georgios, Christodoulou, Eirini, Kiriakidi, Sofia, Becker-Baldus, Johanna, Stylos, Evgenios K, Chatziathanasiadou, Maria V, Chatzigiannis, Christos M, Damalas, Dimitrios E, Aksoydan, Busecan, Javornik, Uroš, Valsami, Georgia, Glaubitz, Clemens, Durdagi, Serdar, Thomaidis, Nikolaos S, Kolocouris, Antonios, Plavec, Janez, Tzakos, Andreas G, Liapakis, George, Mavromoustakos, Thomas

“…Renin–angiotensin aldosterone system inhibitors are for a long time extensively used for the treatment of cardiovascular and renal diseases. AT1 receptor…”
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Development and validation of simple step protein precipitation UHPLC-MS/MS methods for quantitation of temozolomide in cancer patient plasma samples by El Mubarak, Mohamed A., Stylos, Evgenios K., Chatziathanasiadou, Maria V., Danika, Charikleia, Alexiou, George A., Tsekeris, Periklis, Renziehausen, Alexander, Crook, Tim, Syed, Nelofer, Sivolapenko, Gregory B., Tzakos, Andreas G.

“…•Development of two cost-effective methods for quantitation of TMZ in human plasma.•A simple protein precipitation step is used in the sample preparation.•The…”
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Single Peptide Backbone Surrogate Mutations to Regulate Angiotensin GPCR Subtype Selectivity by Vrettos, Eirinaios I., Valverde, Ibai E., Mascarin, Alba, Pallier, Patrick N., Cerofolini, Linda, Fragai, Marco, Parigi, Giacomo, Hirmiz, Baydaa, Bekas, Nick, Grob, Nathalie M., Stylos, Evgenios Κ., Shaye, Hamidreza, Del Borgo, Mark, Aguilar, Marie‐Isabel, Magnani, Francesca, Syed, Nelofer, Crook, Timothy, Waqif, Emal, Ghazaly, Essam, Cherezov, Vadim, Widdop, Robert E., Luchinat, Claudio, Michael‐Titus, Adina T., Mindt, Thomas L., Tzakos, Andreas G.

“…Mutating the side‐chains of amino acids in a peptide ligand, with unnatural amino acids, aiming to mitigate its short half‐life is an established approach…”
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Development of a validated LC-MS/MS method for the in vitro and in vivo quantitation of sunitinib in glioblastoma cells and cancer patients by Chatziathanasiadou, Maria V., Stylos, Evgenios K., Giannopoulou, Efstathia, Spyridaki, Maria-Helen, Briasoulis, Evangelos, Kalofonos, Haralabos P., Crook, Tim, Syed, Nelofer, Sivolapenko, Gregory B., Tzakos, Andreas G.

“…•A cost-effective and rapid bioanalytical method for quantitation of sunitinib.•A simple protein precipitation step is used in the sample preparation.•The…”
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Tailoring acyclovir prodrugs with enhanced antiviral activity: rational design, synthesis, human plasma stability and in vitro evaluation by Chayrov, Radoslav L., Stylos, Evgenios K., Chatziathanasiadou, Maria V., Chuchkov, Kiril N., Tencheva, Aleksandra I., Kostagianni, Androniki D., Milkova, Tsenka S., Angelova, Assia L., Galabov, Angel S., Shishkov, Stoyan A., Todorov, Daniel G., Tzakos, Andreas G., Stankova, Ivanka G.

“…Bile acid prodrugs have served as a viable strategy for refining the pharmaceutical profile of parent drugs through utilizing bile acid transporters. A series…”
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Novel stable analogues of the neurotensin C-terminal hexapeptide containing unnatural amino acids by Magafa, Vassiliki, Matsoukas, Minos-Timotheos, Karageorgos, Vlasios, Dermitzaki, Eirini, Exarchakou, Revekka, Stylos, Evgenios Κ., Pardalos, Michail, Margioris, Andrew N., Varvounis, George, Tzakos, Andreas G., Spyroulias, Georgios A., Liapakis, George

“…Neurotensin (NT) (pGlu–Leu–Tyr–Glu–Asn–Lys–Pro–Arg–Arg–Pro–Tyr–Ile–Leu) exerts a dual function as a neurotransmitter/neuromodulator in the central nervous…”
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Discovery of a stable tripeptide targeting the N-domain of CRF1 receptor by Liapakis, George, Karageorgos, Vlasios, Andreadelis, Ioannis, Holz, George G., Dermitzaki, Eirini, Kordopati, Golfo G., Stylos, Evgenios Κ., Spyridaki, Katerina, Poulaki, Smaragda, Ntountaniotis, Dimitris, Sakellaris, Stelios, Vanioti, Marianna, Kostagianni, Androniki, Marousis, Konstantinos D., Leonis, Georgios, Kokotos, George, Venihaki, Maria, Spyroulias, Georgios A., Tselios, Theodoros, Margioris, Andrew, Tzakos, Andreas G., Mavromoustakos, Thomas

“…The corticotropin-releasing factor (CRF) and its CRF1 receptor (CRF 1 R) play a central role in the maintenance of homeostasis. Malfunctioning of the CRF/CRF 1…”
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