Search Results - "Stykel, Morgan G"

Cardiolipin exposure on the outer mitochondrial membrane modulates α-synuclein by Ryan, Tammy, Bamm, Vladimir V., Stykel, Morgan G., Coackley, Carla L., Humphries, Kayla M., Jamieson-Williams, Rhiannon, Ambasudhan, Rajesh, Mosser, Dick D., Lipton, Stuart A., Harauz, George, Ryan, Scott D.

“…Neuronal loss in Parkinson’s disease (PD) is associated with aberrant mitochondrial function and impaired proteostasis. Identifying the mechanisms that link…”
Get full text

Nitrosative stress in Parkinson’s disease by Stykel, Morgan G., Ryan, Scott D.

“…Parkinson’s Disease (PD) is a neurodegenerative disorder characterized, in part, by the loss of dopaminergic neurons within the nigral-striatal pathway…”
Get full text

Temporal Analysis of Gene Expression in the Murine Schwann Cell Lineage and the Acutely Injured Postnatal Nerve by Balakrishnan, Anjali, Stykel, Morgan G, Touahri, Yacine, Stratton, Jo Anne, Biernaskie, Jeff, Schuurmans, Carol

“…Schwann cells (SCs) arise from neural crest cells (NCCs) that first give rise to SC precursors (SCPs), followed by immature SCs, pro-myelinating SCs, and…”
Get full text

Overtraining Strengthens the Visual Discrimination Memory Trace Outside the Hippocampus in Male Rats by Lehmann, Hugo, Stykel, Morgan G, Glenn, Melissa J

“…The hippocampus (HPC) may compete with other memory systems when establishing a representation, a process termed overshadowing. However, this overshadowing may…”
Get full text

The immunomodulatory properties of adult skin-derived precursor Schwann cells: implications for peripheral nerve injury therapy by Stratton, Jo Anne, Shah, Prajay T., Kumar, Ranjan, Stykel, Morgan G., Shapira, Yuval, Grochmal, Joey, Guo, Gui Fang, Biernaskie, Jeff, Midha, Rajiv

“…Skin‐derived precursor Schwann cell (SKPSC) therapy has been identified as a potentially beneficial treatment for peripheral nerve injuries. One hypothesised…”
Get full text

Author Correction: Nitrosative stress in Parkinson’s disease by Stykel, Morgan G., Ryan, Scott D.

Get full text

Genetic and pharmacological reduction of CDK14 mitigates synucleinopathy by Parmasad, Jean-Louis A., Ricke, Konrad M., Nguyen, Benjamin, Stykel, Morgan G., Buchner-Duby, Brodie, Bruce, Amanda, Geertsma, Haley M., Lian, Eric, Lengacher, Nathalie A., Callaghan, Steve M., Joselin, Alvin, Tomlinson, Julianna J., Schlossmacher, Michael G., Stanford, William L., Ma, Jiyan, Brundin, Patrik, Ryan, Scott D., Rousseaux, Maxime W. C.

“…Parkinson’s disease (PD) is a debilitating neurodegenerative disease characterized by the loss of midbrain dopaminergic neurons (DaNs) and the abnormal…”
Get full text

Network analysis of S-nitrosylated synaptic proteins demonstrates unique roles in health and disease by Stykel, Morgan G., Ryan, Scott D.

“…Nitric oxide can covalently modify cysteine thiols on target proteins to alter that protein's function in a process called S-nitrosylation (SNO)…”
Get full text

Nitration of microtubules blocks axonal mitochondrial transport in a human pluripotent stem cell model of Parkinson's disease by Stykel, Morgan G., Humphries, Kayla, Kirby, Mathew P., Czaniecki, Chris, Wang, Tinya, Ryan, Tammy, Bamm, Vladimir, Ryan, Scott D.

“…ABSTRACT Neuronal loss in Parkinson's disease (PD) is associated with aberrant mitochondrial function in dopaminergic (DA) neurons of the substantia nigra pars…”
Get full text

Intracellular Accumulation of α-Synuclein Aggregates Promotes S-Nitrosylation of MAP1A Leading to Decreased NMDAR-Evoked Calcium Influx and Loss of Mature Synaptic Spines by Hallam, Ryan D, Buchner-Duby, Brodie, Stykel, Morgan G, Coackley, Carla L, Ryan, Scott D

“…Cortical synucleinopathies, including dementia with Lewy bodies and Parkinson's disease dementia, collectively known as Lewy body dementia, are characterized…”
Get full text

Docosahexanoic acid signals through the Nrf2-Nqo1 pathway to maintain redox balance and promote neurite outgrowth by Drolet, Jennifer, Buchner-Duby, Brodie, Stykel, Morgan G, Coackley, Carla, Kang, Jing X, Ma, David W L, Ryan, Scott D

“…Evidence suggests that n-3 polyunsaturated fatty acids may act as activators of the Nrf2 antioxidant pathway. The antioxidant response, in turn, promotes…”
Get full text

α-Synuclein mutation impairs processing of endomembrane compartments and promotes exocytosis and seeding of α-synuclein pathology by Stykel, Morgan G., Humphries, Kayla M., Kamski-Hennekam, Evelyn, Buchner-Duby, Brodie, Porte-Trachsel, Natalie, Ryan, Tammy, Coackley, Carla L., Bamm, Vladimir V., Harauz, George, Ryan, Scott D.

“…Neuronal loss in Parkinson’s disease (PD) is associated with impaired proteostasis and accumulation of α-syn microaggregates in dopaminergic neurons. These…”
Get full text

Axonal pathology in hPSC-based models of Parkinson’s disease results from loss of Nrf2 transcriptional activity at the Map1b gene locus by Czaniecki, Christopher, Ryan, Tammy, Stykel, Morgan G., Drolet, Jennifer, Heide, Juliane, Hallam, Ryan, Wood, Shalandra, Coackley, Carla, Sherriff, Keith, Bailey, Craig D. C., Ryan, Scott D.

“…While mutations in the SNCA gene (α-synuclein [α-syn]) are causal in rare familial forms of Parkinson’s disease (PD), the prevalence of α-syn aggregates in the…”
Get full text

AlphaB-crystallin regulates remyelination after peripheral nerve injury by Lim, Erin-Mai F., Nakanishi, Stan T., Hoghooghi, Vahid, Eaton, Shane E. A., Palmer, Alexandra L., Frederick, Ariana, Stratton, Jo A., Stykel, Morgan G., Whelan, Patrick J., Zochodne, Douglas W., Biernaskie, Jeffrey, Ousman, Shalina S.

“…AlphaB-crystallin (αBC) is a small heat shock protein that is constitutively expressed by peripheral nervous system (PNS) axons and Schwann cells. To determine…”
Get full text

Serum‐free bioprocessing of adult human and rodent skin‐derived Schwann cells: implications for cell therapy in nervous system injury by Mirfeizi, Leila, Stratton, Jo Anne, Kumar, Ranjan, Shah, Prajay, Agabalyan, Natacha, Stykel, Morgan G., Midha, Rajiv, Biernaskie, Jeff, Kallos, Michael S.

“…Peripheral nerve injury affects 2.8% of trauma patients with severe cases often resulting in long‐lived permanent disability, despite nerve repair surgery…”
Get full text

Cyclosporine-immunosuppression does not affect survival of transplanted skin-derived precursor Schwann cells in the injured rat spinal cord by May, Zacnicte, Torres-Espín, Abel, Lucas-Osma, Ana M., Batty, Nicholas J., Raposo, Pamela, Fenrich, Keith K., Stykel, Morgan G., Führmann, Tobias, Shoichet, Molly, Biernaskie, Jeff, Fouad, Karim

“…•Skin-derived precursor Schwann cells were grafted into rats with SCI.•The effect of immune rejection on cell grafts was explored.•Immunosuppression did not…”
Get full text

Nitration of Microtubules Blocks Axonal Mitochondrial Transport in a Human Pluripotent Stem Cell Model of Parkinson's Disease by Stykel, Morgan G., Kirby, Mathew P., Czaniecki, Christopher, Humphries, Kayla, Ryan, Tammy L., Ryan, Scott D.

“…Introduction Neuronal loss in Parkinson's disease (PD) is associated with both accumulation of aggregated α‐synuclein (α‐syn) and impaired mitochondrial…”
Get full text

Cardiolipin exposure on the outer mitochondrial membrane modulates α‐synuclein proteostasis in hPSC‐derived Parkinson's Disease neurons by Ryan, Scott D., Ryan, Tammy L., Bamm, Vladamir V., Stykel, Morgan G., Coackley, Carla C., Humphries, Kayla, Harauz, George

“…Introduction The decline of voluntary motor function in Parkinson's disease (PD) is caused by loss of A9 dopaminergic (DA) neurons in the substantia nigra pars…”
Get full text

The immunomodulatory properties of adult skin‐derived precursor S chwann cells: implications for peripheral nerve injury therapy by Stratton, Jo Anne, Shah, Prajay T., Kumar, Ranjan, Stykel, Morgan G., Shapira, Yuval, Grochmal, Joey, Guo, Gui Fang, Biernaskie, Jeff, Midha, Rajiv

“…Abstract Skin‐derived precursor Schwann cell ( SKPSC ) therapy has been identified as a potentially beneficial treatment for peripheral nerve injuries. One…”
Get full text

Serum-free bioprocessing of adult human and rodent skin-derived Schwann cells: implications for cell therapy in nervous system injury: Adult SKPSC bioprocessing for treating nervous system injury by Mirfeizi, Leila, Stratton, Jo Anne, Kumar, Ranjan, Shah, Prajay, Agabalyan, Natacha, Stykel, Morgan G., Midha, Rajiv, Biernaskie, Jeff, Kallos, Michael S.

Get full text