Search Results - "Styduhar, Evan D."

Total Synthesis of (−)-N-Methylwelwitindolinone C Isothiocyanate by Huters, Alexander D, Quasdorf, Kyle W, Styduhar, Evan D, Garg, Neil K

“…We report the first total synthesis of (−)-N-methylwelwitindolinone C isothiocyanate. Our route features a number of key transformations, including an indolyne…”
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Total Synthesis of (−)‑N‑Methylwelwitindolinone B Isothiocyanate via a Chlorinative Oxabicycle Ring-Opening Strategy by Weires, Nicholas A, Styduhar, Evan D, Baker, Emma L, Garg, Neil K

“…The first total synthesis of N-methylwelwitindolinone B isothiocyanate is reported. The route features several key steps, including a regio- and…”
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Enantiospecific Total Synthesis of N-Methylwelwitindolinone D Isonitrile by Styduhar, Evan D., Huters, Alexander D., Weires, Nicholas A., Garg, Neil K.

“…The total synthesis of N‐methylwelwitindolinone D isonitrile (1) has been achieved in 17 steps from a readily available carvone derivative. The route features…”
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Nitrone Cycloadditions of 1,2-Cyclohexadiene by Barber, Joyann S, Styduhar, Evan D, Pham, Hung V, McMahon, Travis C, Houk, K. N, Garg, Neil K

“…We report the first 1,3-dipolar cycloadditions of 1,2-cyclohexadiene, a rarely exploited strained allene. 1,2-Cyclohexadiene is generated in situ under mild…”
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Total Syntheses of the Elusive Welwitindolinones with Bicyclo[4.3.1] Cores by Huters, Alexander D., Styduhar, Evan D., Garg, Neil K.

“…The welwitindolinones with bicyclo[4.3.1] cores are a class of natural products that have attracted tremendous interest from the synthetic community because of…”
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On-Demand Generation and Use in Continuous Synthesis of the Ambiphilic Nitrogen Source Chloramine by Danahy, Kelley E, Styduhar, Evan D, Fodness, Aria M, Heckman, Laurel M, Jamison, Timothy F

“…Herein, we demonstrate the on-demand synthesis of chloramine from aqueous ammonia and sodium hypochlorite solutions, and its subsequent utilization as an…”
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Xenoprotein engineering via synthetic libraries by Gates, Zachary P., Vinogradov, Alexander A., Quartararo, Anthony J., Bandyopadhyay, Anupam, Choo, Zi-Ning, Evans, Ethan D., Halloran, Kathryn H., Mijalis, Alexander J., Mong, Surin K., Simon, Mark D., Standley, Eric A., Styduhar, Evan D., Tasker, Sarah Z., Touti, Faycal, Weber, Jessica M., Wilson, Jessica L., Jamison, Timothy F., Pentelute, Bradley L.

“…Chemical methods have enabled the total synthesis of protein molecules of ever-increasing size and complexity. However, methods to engineer synthetic proteins…”
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Potent and Selective Biaryl Amide Inhibitors of Hematopoietic Progenitor Kinase 1 (HPK1) by Sokolsky, Alexander, Vechorkin, Oleg, Hummel, Joshua R., Styduhar, Evan D., Wang, Anlai, Nguyen, Minh H., Ye, Hai Fen, Liu, Kai, Zhang, Ke, Pan, Jun, Ye, Qinda, Atasoylu, Onur, Behshad, Elham, He, Xin, Conlen, Patricia, Stump, Kristine, Ye, Min, Diamond, Sharon, Covington, Maryanne, Yeleswaram, Swamy, Yao, Wenqing

“…Herein we report the discovery of a novel biaryl amide series as selective inhibitors of hematopoietic protein kinase 1 (HPK1). Structure–activity relationship…”
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Discovery of Novel Pyrazolopyrimidines as Potent, Selective, and Orally Bioavailable Inhibitors of ALK2 by Nguyen, Minh H., Atasoylu, Onur, Wu, Liangxing, Kapilashrami, Kanishk, Pusey, Michelle, Gallagher, Karen, Lai, Cheng-Tsung, Zhao, Peng, Barbosa, Joseph, Liu, Kai, He, Chunhong, Zhang, Colin, Styduhar, Evan D., Witten, Michael R., Chen, Yaoyu, Lin, Luping, Yang, Yan-ou, Covington, Maryanne, Diamond, Sharon, Yeleswaram, Swamy, Yao, Wenqing

“…Activin receptor-like kinase 2 (ALK2) is a transmembrane kinase receptor that mediates the signaling of the members of the TGF-β superfamily. The aberrant…”
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Discovery of Orally Bioavailable FGFR2/FGFR3 Dual Inhibitors via Structure-Guided Scaffold Repurposing Approach by Nguyen, Minh H., Ye, Hai-Fen, Xu, Yao, Truong, Lisa, Horsey, April, Zhao, Peng, Styduhar, Evan D., Frascella, Michelle, Leffet, Lynn, Federowicz, Kelly, Behshad, Elham, Wang, Anlai, Zhang, Ke, Witten, Michael R., Qi, Chao, Jalluri, Ravi, Lai, Cheng-Tsung, Atasoylu, Onur, Harris, Jennifer J., Hess, Rodrigo, Lin, Luping, Zhang, Guofeng, Covington, Maryanne, Diamond, Sharon, Yao, Wenqing, Vechorkin, Oleg

“…Fibroblast growth factor receptors (FGFRs) are transmembrane receptor tyrosine kinases that regulate multiple physiological processes. Aberrant activation of…”
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Totalsynthesen der Welwitindolinone mit Bicyclo[4.3.1]-Kern by Huters, Alexander D., Styduhar, Evan D., Garg, Neil K.

“…Die Welwitindolinone mit einem Bicyclo[4.3.1]‐Kern sind eine Klasse von Naturstoffen, die aufgrund ihrer faszinierenden Strukturen und ihrer vielversprechenden…”
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Enantiospecific Total Synthesis of N-MethylwelwitindolinoneD Isonitrile by Styduhar, Evan D, Huters, Alexander D, Weires, Nicholas A, Garg, Neil K

“…The total synthesis of N-methylwelwitindolinoneD isonitrile (1) has been achieved in 17 steps from a readily available carvone derivative. The route features a…”
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Totalsynthesen der Welwitindolinone mit Bicyclo[4.3.1]‐Kern by Huters, Alexander D., Styduhar, Evan D., Garg, Neil K.

“…Die Welwitindolinone mit einem Bicyclo[4.3.1]‐Kern sind eine Klasse von Naturstoffen, die aufgrund ihrer faszinierenden Strukturen und ihrer vielversprechenden…”
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Enantiospecific Total Synthesis of N-Methylwelwitindolinone D Isonitrile by Styduhar, Evan D., Huters, Alexander D., Weires, Nicholas A., Garg, Neil K.

“…Die Totalsynthese von N‐Methylwelwitindolinon‐D‐isonitril (1) gelang in 17 Schritten ausgehend von einem leicht zugänglichen Carvonderivat. Die Syntheseroute…”
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Enantiospecific Total Synthesis of N ‐Methylwelwitindolinone D Isonitrile by Styduhar, Evan D., Huters, Alexander D., Weires, Nicholas A., Garg, Neil K.

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Enantiospecific Total Synthesis of N-MethylwelwitindolinoneD Isonitrile by Styduhar, Evan D, Huters, Alexander D, Weires, Nicholas A, Garg, Neil K

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