Search Results - "Stutzmann, Grace E"

Endoplasmic Reticulum Ca2+ Handling in Excitable Cells in Health and Disease by Stutzmann, Grace E, Mattson, Mark P

“…The endoplasmic reticulum (ER) is a morphologically and functionally diverse organelle capable of integrating multiple extracellular and internal signals and…”
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Ca2+ Dyshomeostasis Disrupts Neuronal and Synaptic Function in Alzheimer’s Disease by McDaid, John, Mustaly-Kalimi, Sarah, Stutzmann, Grace E.

“…Ca2+ homeostasis is essential for multiple neuronal functions and thus, Ca2+ dyshomeostasis can lead to widespread impairment of cellular and synaptic…”
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Deviant Ryanodine Receptor-Mediated Calcium Release Resets Synaptic Homeostasis in Presymptomatic 3xTg-AD Mice by Chakroborty, Shreaya, Goussakov, Ivan, Miller, Megan B, Stutzmann, Grace E

“…Presenilin mutations result in exaggerated endoplasmic reticulum (ER) calcium release in cellular and animal models of Alzheimer's disease (AD). In this study,…”
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Nitric oxide signaling is recruited as a compensatory mechanism for sustaining synaptic plasticity in Alzheimer's disease mice by Chakroborty, Shreaya, Kim, Joyce, Schneider, Corinne, West, Anthony R, Stutzmann, Grace E

“…Synaptic plasticity deficits are increasingly recognized as causing the memory impairments which define Alzheimer's disease (AD). In AD mouse models, evidence…”
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NMDA-Mediated Ca2+ Influx Drives Aberrant Ryanodine Receptor Activation in Dendrites of Young Alzheimer's Disease Mice by Goussakov, Ivan, Miller, Megan B, Stutzmann, Grace E

“…Deficits in synaptic function, particularly through NMDA receptors (NMDARs), are linked to late-stage cognitive impairments in Alzheimer's disease (AD). At…”
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Stabilizing ER Ca2+ channel function as an early preventative strategy for Alzheimer's disease by Chakroborty, Shreaya, Briggs, Clark, Miller, Megan B, Goussakov, Ivan, Schneider, Corinne, Kim, Joyce, Wicks, Jaime, Richardson, Jill C, Conklin, Vincent, Cameransi, Benjamin G, Stutzmann, Grace E

“…Alzheimer's disease (AD) is a devastating neurodegenerative condition with no known cure. While current therapies target late-stage amyloid formation and…”
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Enhanced Ryanodine Receptor Recruitment Contributes to Ca2+ Disruptions in Young, Adult, and Aged Alzheimer's Disease Mice by Stutzmann, Grace E, Smith, Ian, Caccamo, Antonella, Oddo, Salvatore, LaFerla, Frank M, Parker, Ian

“…Neuronal Ca2+ signaling through inositol triphosphate receptors (IP3R) and ryanodine receptors (RyRs) must be tightly regulated to maintain cell viability,…”
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Therapeutic correction of ApoER2 splicing in Alzheimer's disease mice using antisense oligonucleotides by Hinrich, Anthony J, Jodelka, Francine M, Chang, Jennifer L, Brutman, Daniella, Bruno, Angela M, Briggs, Clark A, James, Bryan D, Stutzmann, Grace E, Bennett, David A, Miller, Steven A, Rigo, Frank, Marr, Robert A, Hastings, Michelle L

“…Apolipoprotein E receptor 2 ( ApoER2 ) is an apolipoprotein E receptor involved in long‐term potentiation, learning, and memory. Given its role in cognition…”
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Altered ryanodine receptor expression in mild cognitive impairment and Alzheimer's disease by Bruno, Angela M, Huang, Jeff Y, Bennett, David A, Marr, Robert A, Hastings, Michelle L, Stutzmann, Grace E

“…Abstract Intracellular Ca2+ dysregulation is an underlying component of Alzheimer's disease (AD) pathophysiology, and recent evidence implicates the ryanodine…”
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Oxidative Phosphorylation Is Dysregulated Within the Basocortical Circuit in a 6-month old Mouse Model of Down Syndrome and Alzheimer’s Disease by Alldred, Melissa J., Lee, Sang Han, Stutzmann, Grace E., Ginsberg, Stephen D.

“…Down syndrome (DS) is the primary genetic cause of intellectual disability (ID), which is due to the triplication of human chromosome 21 (HSA21). In addition…”
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Calcium Dysregulation, IP3 Signaling, and Alzheimer’s Disease by Stutzmann, Grace E.

“…Ca2+ ions subserve complex signaling roles in neurons, regulating functions ranging from gene transcription to modulation of membrane excitability. Ca2+ ions…”
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Reduced presynaptic vesicle stores mediate cellular and network plasticity defects in an early-stage mouse model of Alzheimer's disease by Chakroborty, Shreaya, Hill, Evan S, Christian, Daniel T, Helfrich, Rosalind, Riley, Shannon, Schneider, Corinne, Kapecki, Nicolas, Mustaly-Kalimi, Sarah, Seiler, Figen A, Peterson, Daniel A, West, Anthony R, Vertel, Barbara M, Frost, William N, Stutzmann, Grace E

“…Identifying effective strategies to prevent memory loss in AD has eluded researchers to date, and likely reflects insufficient understanding of early…”
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NCLX controls hepatic mitochondrial Ca2+ extrusion and couples hormone-mediated mitochondrial Ca2+ oscillations with gluconeogenesis by Taha, Mahmoud, Assali, Essam A., Ben-Kasus Nissim, Tsipi, Stutzmann, Grace E., Shirihai, Orian S., Hershfinkel, Michal, Sekler, Israel

“…Hepatic Ca2+ signaling has been identified as a crucial key factor in driving gluconeogenesis. The involvement of mitochondria in hormone-induced Ca2+…”
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Human-Induced Neurons from Presenilin 1 Mutant Patients Model Aspects of Alzheimer's Disease Pathology by Schrank, Sean, McDaid, John, Briggs, Clark A, Mustaly-Kalimi, Sarah, Brinks, Deanna, Houcek, Aiden, Singer, Oded, Bottero, Virginie, Marr, Robert A, Stutzmann, Grace E

“…Traditional approaches to studying Alzheimer's disease (AD) using mouse models and cell lines have advanced our understanding of AD pathogenesis. However, with…”
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Age- and sex-related changes in cortical and striatal nitric oxide synthase in the Q175 mouse model of Huntington's disease by Padovan-Neto, Fernando E., Jurkowski, Lauren, Murray, Conor, Stutzmann, Grace E., Kwan, Mei, Ghavami, Afshin, Beaumont, Vahri, Park, Larry C., West, Anthony R.

“…In Huntington's disease (HD), corticostriatal and striatopallidal projection neurons preferentially degenerate as a result of mutant huntingtin expression…”
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Sustained Hippocampal Synaptic Pathophysiology Following Single and Repeated Closed-Head Concussive Impacts by McDaid, John, Briggs, Clark A, Barrington, Nikki M, Peterson, Daniel A, Kozlowski, Dorothy A, Stutzmann, Grace E

“…Traumatic brain injury (TBI), and related diseases such as chronic traumatic encephalopathy (CTE) and Alzheimer's (AD), are of increasing concern in part due…”
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Engineered neurogenesis in naïve adult rat cortex by Ngn2-mediated neuronal reprogramming of resident oligodendrocyte progenitor cells by Bazarek, Stanley F., Thaqi, Mentor, King, Patrick, Mehta, Amol R., Patel, Ronil, Briggs, Clark A., Reisenbigler, Emily, Yousey, Jonathon E., Miller, Elis A., Stutzmann, Grace E., Marr, Robert A., Peterson, Daniel A.

“…Adult tissue stem cells contribute to tissue homeostasis and repair but the long-lived neurons in the human adult cerebral cortex are not replaced, despite…”
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Calcium-Handling Defects and Neurodegenerative Disease by Schrank, Sean, Barrington, Nikki, Stutzmann, Grace E

“…Calcium signaling is critical to neuronal function and regulates highly diverse processes such as gene transcription, energy production, protein handling, and…”
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Phosphodiesterase 9A Inhibition Facilitates Corticostriatal Transmission in Wild-Type and Transgenic Rats That Model Huntington’s Disease by Chakroborty, Shreaya, Manfredsson, Fredric P., Dec, Alexander M., Campbell, Peter W., Stutzmann, Grace E., Beaumont, Vahri, West, Anthony R.

“…Huntington’s disease (HD) results from abnormal expansion in CAG trinucleotide repeats within the HD gene, a mutation which leads to degeneration of striatal…”
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Calcium Signaling and Amyloid Toxicity in Alzheimer Disease by Demuro, Angelo, Parker, Ian, Stutzmann, Grace E.

“…Intracellular Ca2+ signaling is fundamental to neuronal physiology and viability. Because of its ubiquitous roles, disruptions in Ca2+ homeostasis are…”
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