Search Results - "Stuttle, A"

Anti-inflammatory 17β-Thioalkyl-16α,17α-ketal and -acetal Androstanes:  A New Class of Airway Selective Steroids for the Treatment of Asthma by Ashton, Michael J, Lawrence, Christopher, Karlsson, Jan-Anders, Stuttle, Keith A. J, Newton, Christopher G, Vacher, Bernard Y. J, Webber, Stephen, Withnall, Michael J

“…The synthesis and anti-inflammatory potencies of a new class of 17β-thioalkyl-16α,17α-ketal and -acetal androstanes are described. This new class of steroids…”
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Intrasplenic blood cell kinetics in man before and after brief maximal exercise by Allsop, P, Peters, A M, Arnot, R N, Stuttle, A W, Deenmamode, M, Gwilliam, M E, Myers, M J, Hall, G M

“…1. After a 4 min period of maximal exercise in 10 normal subjects (14 studies), there was a consistent decrease in total blood volume and a consistent increase…”
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Granulocyte margination in the human lung and its response to strenuous exercise by Peters, A M, Allsop, P, Stuttle, A W, Arnot, R N, Gwilliam, M, Hall, G M

“…1. It is widely believed that the lung is an important site of granulocyte margination and releases most of the granulocytes of the peripheral neutrophilia of…”
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Imaging of bone infection with labelled white blood cells: role of contemporaneous bone marrow imaging by King, A D, Peters, A M, Stuttle, A W, Lavender, J P

“…The uptake of white blood cells (WBC) into normal bone marrow may lead to difficulty in detecting bone infection. Twenty-one patients in whom the WBC scan was…”
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New Low-Density Lipoprotein Receptor Upregulators Acting via a Novel Mechanism by Ashton, Michael J, Brown, Thomas J, Fenton, Garry, Halley, Frank, Harper, Mark F, Lockey, Peter M, Porter, Barry, Roach, Alan G, Stuttle, Keith A. J, Vicker, Nigel, Walsh, Roger J. A

“…The synthesis and biological activity of a new series of benzamides and related compounds that upregulate the expression of the low-density lipoprotein (LDL)…”
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Effects of a monoclonal antibody to glycoprotein IIb/IIIa (P256) and of enzymically derived fragments of P256 on human platelets by Stuttle, A W, Powling, M J, Ritter, J M, Hardisty, R M

“…The anti-platelet monoclonal antibody P256 is currently undergoing development for in vivo detection of thrombus. We have examined the actions of P256 and two…”
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Sequential imaging of post-operative thrombus using the In-111-labelled platelet-specific monoclonal antibody P256 by Stuttle, A W, Klosok, J, Peters, A M, Lavender, J P

“…Eleven patients undergoing total hip replacement were studied by radioimmunoscintigraph for development of postoperative thrombus. Images were obtained using…”
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Indium-111 Whole-Body Retention: A Method for Quantification of Disease Activity in Inflammatory Bowel Disease by de Kaski, Marta Carpani, Peters, A. Michael, Knight, Deborah, Stuttle, Alan W. J, Lavender, J. Peter, Hodgson, Humphrey J

“…Quantification of disease activity in inflammatory bowel disease (IBD) has been by measurement of fecal excretion of 111In-granulocytes. The difficulties of…”
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In vitro studies with an anti-platelet monoclonal antibody; P256 by Stuttle, A W, Ritter, J M, Peters, A M, Lavender, J P

“…P256 is a platelet-specific monoclonal antibody. It has potential as a diagnostic agent for use in thrombus detection by radioimmunoscintigraphy. However, the…”
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Anti-platelet monoclonal antibody P256 in the diagnosis of renal transplant rejection by Carpani de Kaski, M, Keane, P F, Stuttle, A W, Lavender, J P, Williams, G, Peters, A M

“…Platelets labeled in vitro with In-111 have a recognized place in the diagnosis of renal transplant rejection. Following their introduction for imaging…”
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In vivo studies with an anti-platelet monoclonal antibody; P256 by Lavender, J P, Stuttle, A W, Peters, A M, O'Donnell, C J, Davies, G J, Harrison, R, Hogg, N

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Use of an anti-platelet monoclonal antibody F(ab')2 fragment for imaging thrombus by Stuttle, A W, Peters, A M, Loutfi, I, Lumley, P, George, P, Lavender, J P

“…Ten patients with suspected thrombus have been studied using 111In-labelled F(ab')2 fragments of P256, a monoclonal antibody which recognizes an epitope on the…”
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99Tcm-HMPAO labelled leucocytes: comparison with 111In-tropolonate labelled granulocytes by Peters, A M, Roddie, M E, Danpure, H J, Osman, S, Zacharopoulos, G P, George, P, Stuttle, A W, Lavender, J P

“…The lipophilic complex, 99Tcm-hexamethylpropyleneamine oxime (HMPAO) is an efficient leucocyte label, and labels granulocytes with more stability than…”
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Imaging of metastatic melanoma utilising a technetium-99m labelled RGD-containing synthetic peptide by Sivolapenko, G B, Skarlos, D, Pectasides, D, Stathopoulou, E, Milonakis, A, Sirmalis, G, Stuttle, A, Courtenay-Luck, N S, Konstantinides, K, Epenetos, A A

“…Integrins are cell-surface glycoproteins found in different forms on all cells except erythrocytes. Integrins bind to cell adhesion molecules and to proteins…”
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Evidence for a dual pathway in platelet activating factor-induced aggregation of rat polymorphonuclear leucocytes by Moodley, I, Stuttle, A

“…The purpose of this study was to determine the role, if any, of Leukotriene B4 (LTB4) in Platelet Activating Factor (PAF)-induced aggregation of rat…”
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Platelet imaging of thromboembolism. Natural history of postoperative deep venous thrombosis and pulmonary embolism illustrated using the 111In-labelled platelet-specific monoclonal antibody, P256 by King, A D, Bell, S D, Stuttle, A W, Carpani de Kaski, M, Peters, A M, Lavender, J P

“…Deep venous thrombosis (DVT) and pulmonary thromboembolic disease are difficult to diagnose, particularly following surgery. This report demonstrates the use…”
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Inhaled platelet-activating factor causes pulmonary neutrophil sequestration in normal humans by Tam, F W, Clague, J, Dixon, C M, Stuttle, A W, Henderson, B L, Peters, A M, Lavender, J P, Ind, P W

“…Inhaled platelet-activating factor (PAF) causes bronchoconstriction and transient peripheral neutropenia in humans. We studied eight normal subjects to…”
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Prostaglandins. Part 4. Synthesis of (+/-)-11-deoxyprostaglandins from 2-(omega-hydroxyheptyl)cyclopent-2-enones by Burton, T S, Caton, M P, Coffee, E C, Parker, T, Stuttle, A J, Watkins, G L

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Imaging venous thrombosis with indium-111 labelled P256 Fab by Stuttle, A W, Klosok, J, Peters, A M, Henderson, B L, Lavender, J P

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A structural analog of thromboxane A2 by Ansell, M F, Caton, M P, Palfreyman, M N, Stuttle, K A, Tuffin, D, Walker, J L

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