Search Results - "Stursa, Jan"

Targeting Mitochondrial Iron Metabolism Suppresses Tumor Growth and Metastasis by Inducing Mitochondrial Dysfunction and Mitophagy by Sandoval-Acuña, Cristian, Torrealba, Natalia, Tomkova, Veronika, Jadhav, Sukanya B, Blazkova, Kristyna, Merta, Ladislav, Lettlova, Sandra, Adamcová, Miroslava K, Rosel, Daniel, Brábek, Jan, Neuzil, Jiri, Stursa, Jan, Werner, Lukas, Truksa, Jaroslav

“…Deferoxamine (DFO) represents a widely used iron chelator for the treatment of iron overload. Here we describe the use of mitochondrially targeted deferoxamine…”
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Designing the nanobiointerface of fluorescent nanodiamonds: highly selective targeting of glioma cancer cells by Slegerova, Jitka, Hajek, Miroslav, Rehor, Ivan, Sedlak, Frantisek, Stursa, Jan, Hruby, Martin, Cigler, Petr

“…Core-shell nanoparticles based on fluorescent nanodiamonds coated with a biocompatible N-(2-hydroxypropyl)methacrylamide copolymer shell were developed for…”
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Mitochondrially targeted tamoxifen alleviates markers of obesity and type 2 diabetes mellitus in mice by Vacurova, Eliska, Trnovska, Jaroslava, Svoboda, Petr, Skop, Vojtech, Novosadova, Vendula, Reguera, David Pajuelo, Petrezselyová, Silvia, Piavaux, Benoit, Endaya, Berwini, Spoutil, Frantisek, Zudova, Dagmar, Stursa, Jan, Melcova, Magdalena, Bielcikova, Zuzana, Werner, Lukas, Prochazka, Jan, Sedlacek, Radislav, Huttl, Martina, Hubackova, Sona Stemberkova, Haluzik, Martin, Neuzil, Jiri

“…Type 2 diabetes mellitus represents a major health problem with increasing prevalence worldwide. Limited efficacy of current therapies has prompted a search…”
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SMAD4 loss limits the vulnerability of pancreatic cancer cells to complex I inhibition via promotion of mitophagy by Ezrova, Zuzana, Nahacka, Zuzana, Stursa, Jan, Werner, Lukas, Vlcak, Erik, Kralova Viziova, Petra, Berridge, Michael V., Sedlacek, Radislav, Zobalova, Renata, Rohlena, Jakub, Boukalova, Stepana, Neuzil, Jiri

“…Pancreatic cancer is one of the deadliest forms of cancer, which is attributed to lack of effective treatment options and drug resistance. Mitochondrial…”
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Metformin directly targets the H3K27me3 demethylase KDM6A/UTX by Cuyàs, Elisabet, Verdura, Sara, Llorach‐Pares, Laura, Fernández‐Arroyo, Salvador, Luciano‐Mateo, Fedra, Cabré, Noemí, Stursa, Jan, Werner, Lukas, Martin‐Castillo, Begoña, Viollet, Benoit, Neuzil, Jiri, Joven, Jorge, Nonell‐Canals, Alfons, Sanchez‐Martinez, Melchor, Menendez, Javier A.

“…Summary Metformin, the first drug chosen to be tested in a clinical trial aimed to target the biology of aging per se, has been clinically exploited for…”
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Extremely rapid isotropic irradiation of nanoparticles with ions generated in situ by a nuclear reaction by Havlik, Jan, Petrakova, Vladimira, Kucka, Jan, Raabova, Helena, Panek, Dalibor, Stepan, Vaclav, Zlamalova Cilova, Zuzana, Reineck, Philipp, Stursa, Jan, Kucera, Jan, Hruby, Martin, Cigler, Petr

“…Energetic ions represent an important tool for the creation of controlled structural defects in solid nanomaterials. However, the current preparative…”
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NDRG1 acts as an oncogene in triple-negative breast cancer and its loss sensitizes cells to mitochondrial iron chelation by Jadhav, Sukanya B, Vondrackova, Michaela, Potomova, Petra, Sandoval-Acuña, Cristian, Smigova, Jana, Klanicova, Kristyna, Rosel, Daniel, Brabek, Jan, Stursa, Jan, Werner, Lukas, Truksa, Jaroslav

“…Multiple studies indicate that iron chelators enhance their anti-cancer properties by inducing NDRG1, a known tumor and metastasis suppressor. However, the…”
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Mitochondrially targeted tamoxifen as anticancer therapy: case series of patients with renal cell carcinoma treated in a phase I/Ib clinical trial by Bielcikova, Zuzana, Werner, Lukas, Stursa, Jan, Cerny, Vladimir, Krizova, Ludmila, Spacek, Jan, Hlousek, Stanislav, Vocka, Michal, Bartosova, Olga, Pesta, Michal, Kolostova, Katarina, Klezl, Petr, Bobek, Vladimir, Truksa, Jaroslav, Stemberkova-Hubackova, Sona, Petruzelka, Lubos, Michalek, Pavel, Neuzil, Jiri

“…Mitochondrially targeted anticancer drugs (mitocans) that disrupt the energy-producing systems of cancer are emerging as new potential therapeutics…”
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Characterisation of mesothelioma-initiating cells and their susceptibility to anti-cancer agents by Pasdar, Elham Alizadeh, Smits, Michael, Stapelberg, Michael, Bajzikova, Martina, Stantic, Marina, Goodwin, Jacob, Yan, Bing, Stursa, Jan, Kovarova, Jaromira, Sachaphibulkij, Karishma, Bezawork-Geleta, Ayenachew, Sobol, Margaryta, Filimonenko, Anatoly, Tomasetti, Marco, Zobalova, Renata, Hozak, Pavel, Dong, Lan-Feng, Neuzil, Jiri

“…Malignant mesothelioma (MM) is an aggressive type of tumour causing high mortality. One reason for this paradigm may be the existence of a subpopulation of…”
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Simultaneous targeting of mitochondrial metabolism and immune checkpoints as a new strategy for renal cancer therapy by Stemberkova‐Hubackova, Sona, Zobalova, Renata, Dubisova, Maria, Smigova, Jana, Dvorakova, Sarka, Korinkova, Klara, Ezrova, Zuzana, Endaya, Berwini, Blazkova, Kristyna, Vlcak, Erik, Brisudova, Petra, Le, Dan‐Diem Thi, Juhas, Stefan, Rosel, Daniel, Daniela Kelemen, Cristina, Sovilj, Dana, Vacurova, Eliska, Cajka, Tomas, Filimonenko, Vlada, Dong, Lanfeng, Andera, Ladislav, Hozak, Pavel, Brabek, Jan, Bielcikova, Zuzana, Stursa, Jan, Werner, Lukas, Neuzil, Jiri

“…A thus far untested approach is targeting mitochondrial respiration using compounds from the group of mitocans,3 epitomised by mitochondrially targeted…”
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Neutron spectrum determination of p+Be reaction for 30 MeV protons using the multi-foil activation technique by Stefanik, Milan, Simeckova, Eva, Bem, Pavel, Majerle, Mitja, Novak, Jan, Ansorge, Martin, Mrazek, Jaromir, Stursa, Jan

“…At the NPI in Rez, the p + Be source reaction was investigated for 30 MeV proton beam and thick beryllium target. For neutron field determination of the…”
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Correction: Characterisation of Mesothelioma-Initiating Cells and Their Susceptibility to Anti-Cancer Agents by Pasdar, Elham Alizadeh, Smits, Michael, Stapelberg, Michael, Bajzikova, Martina, Stantic, Marina, Goodwin, Jacob, Yan, Bing, Stursa, Jan, Kovarova, Jaromira, Sachaphibulkij, Karishma, Bezawork-Geleta, Ayenachew, Sobol, Margaryta, Filimonenko, Anatoly, Tomasetti, Marco, Zobalova, Renata, Hozak, Pavel, Dong, Lan-Feng, Neuzil, Jiri

“…[This corrects the article DOI: 10.1371/journal.pone.0119549.]…”
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Assessment of radionuclidic impurities in cyclotron produced 99mTc by Lebeda, Ondřej, van Lier, Erik J., Štursa, Jan, Ráliš, Jan, Zyuzin, Alexander

“…The commercial viability of cyclotron-produced 99mTc as an alternative to generator-produced 99mTc depends on several factors. These include: production yield,…”
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Enhanced beam extraction system at the U-120M cyclotron by Matlocha, Tomáš, Štursa, Jan, Běhal, Radek, Zach, Václav, Čihák, Milan

“…Since its commissioning in 1977, the U-120M cyclotron was initially equipped with a single pair of harmonic coils aimed at optimizing beam quality at lower…”
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The 4-Aminomethylphenoxy-Benzoxaborole AN3057 as a Potential Treatment Option for Primary Amoebic Meningoencephalitis by Ženíšková, Kateřina, Mach, Jan, Arbon, Dominik, Štursa, Jan, Werner, Lukáš, Zoltner, Martin, Sutak, Robert

“…Primary amoebic meningoencephalitis is a rare but fatal central nervous system (CNS) disease caused by the "brain-eating amoeba" Naegleria fowleri. A major…”
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Comprehensive interrogation of the cellular response to fluorescent, detonation and functionalized nanodiamonds by Moore, Laura, Grobárová, Valéria, Shen, Helen, Man, Han Bin, Míčová, Júlia, Ledvina, Miroslav, Štursa, Jan, Nesladek, Milos, Fišerová, Anna, Ho, Dean

“…Nanodiamonds (NDs) are versatile nanoparticles that are currently being investigated for a variety of applications in drug delivery, biomedical imaging and…”
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Luminescence of Nanodiamond Driven by Atomic Functionalization: Towards Novel Detection Principles by Petráková, Vladimíra, Taylor, Andrew, Kratochvílová, Irena, Fendrych, František, Vacík, Jiří, Kučka, Jan, Štursa, Jan, Cígler, Petr, Ledvina, Miroslav, Fišerová, Anna, Kneppo, Peter, Nesládek, Miloš

“…High biocompatibility, variable size ranging from ≈5 nm, stable luminescence from its color centers, and simple carbon chemistry for biomolecule grafting make…”
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Production of 230U/226Th for Targeted Alpha Therapy via Proton Irradiation of 231Pa by Morgenstern, Alfred, Lebeda, Ondrej, Stursa, Jan, Bruchertseifer, Frank, Capote, Roberto, McGinley, John, Rasmussen, Gert, Sin, Mihaela, Zielinska, Barbara, Apostolidis, Christos

“…230U and its daughter nuclide 226Th are novel therapeutic nuclides for application in targeted α-therapy of cancer. We have investigated the feasibility of…”
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Repurposing of MitoTam: Novel Anti-Cancer Drug Candidate Exhibits Potent Activity against Major Protozoan and Fungal Pathogens by Arbon, Dominik, Ženíšková, Kateřina, Šubrtová, Karolína, Mach, Jan, Štursa, Jan, Machado, Marta, Zahedifard, Farnaz, Leštinová, Tereza, Hierro-Yap, Carolina, Neuzil, Jiri, Volf, Petr, Ganter, Markus, Zoltner, Martin, Zíková, Alena, Werner, Lukáš, Sutak, Robert

“…Many of the currently available anti-parasitic and anti-fungal frontline drugs have severe limitations, including adverse side effects, complex administration,…”
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Microwave-Assisted Alkylation of [CB11H12]− and Related Anions by Valášek, Michal, Štursa, Jan, Pohl, Radek, Michl, Josef

“…A total of 19 permethylated derivatives of substituted [CB11H12]− anions have been prepared using alkylation with microwave assistance. The reactions proceed…”
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