Search Results - "Sturmey, Roger G."

Application of extracellular flux analysis for determining mitochondrial function in mammalian oocytes and early embryos by Muller, Bethany, Lewis, Niamh, Adeniyi, Tope, Leese, Henry J., Brison, Daniel R., Sturmey, Roger G.

“…Mitochondria provide the major source of ATP for mammalian oocyte maturation and early embryo development. Oxygen Consumption Rate (OCR) is an established…”
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The role of fatty acids in oocyte and early embryo development by McKeegan, Paul J, Sturmey, Roger G

“…Growing evidence suggests that endogenous and exogenous fatty acids play diverse roles in developing mammalian oocytes and early embryos. In this review, we…”
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Parallels between embryo and cancer cell metabolism by Smith, Danielle G, Sturmey, Roger G

“…A key characteristic of cancer cells is the ability to switch from a predominantly oxidative metabolism to glycolysis and the production of lactate even when…”
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Elevated non-esterified fatty acid concentrations during bovine oocyte maturation compromise early embryo physiology by Van Hoeck, Veerle, Sturmey, Roger G, Bermejo-Alvarez, Pablo, Rizos, Dimitrios, Gutierrez-Adan, Alfonso, Leese, Henry J, Bols, Peter E J, Leroy, Jo L M R

“…Elevated concentrations of serum non-esterified fatty acids (NEFA), associated with maternal disorders such as obesity and type II diabetes, alter the ovarian…”
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The Quiet Embryo Hypothesis: 20 years on by Leese, Henry J, Brison, Daniel R, Sturmey, Roger G

“…This article revisits the hypothesis, proposed in 2002, that the successful development of oocytes and preimplantation mammalian embryos is associated with a…”
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Genistein crosses the bioartificial oviduct and alters secretion composition by Simintiras, Constantine A., Sturmey, Roger G.

“…•This manuscript utilises an existing technology for the novel application of investigating the effects of genistein on the oviduct in vitro.•The data show…”
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A simple approach for COnsumption and RElease (CORE) analysis of metabolic activity in single mammalian embryos by Guerif, Fabrice, McKeegan, Paul, Leese, Henry J, Sturmey, Roger G

“…Non-invasive assay of the consumption and release of metabolites by individual human embryos could allow selection at the cleavage stage of development and…”
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Intraovarian injection of platelet-rich plasma in assisted reproduction: too much too soon? by Atkinson, Lloyd, Martin, Francesca, Sturmey, Roger G

“…The prospect of ovarian rejuvenation offers the tantalising prospect of treating age-related declines in fertility or in pathological conditions such as…”
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Expression and function of transient receptor potential channels in the female bovine reproductive tract by Ghavideldarestani, Maryam, Atkin, Stephen L., Leese, Henry J., Sturmey, Roger G.

“…The epithelium lining the oviduct is critical for early reproductive events, many of which are mediated via intracellular calcium ions. Despite this, little is…”
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Female reproductive tract fluids: composition, mechanism of formation and potential role in the developmental origins of health and disease by Leese, Henry J, Hugentobler, Sasha A, Gray, Susan M, Morris, Dermot G, Sturmey, Roger G, Whitear, Sarah-Louise, Sreenan, Joseph M

“…The oviduct and uterus provide the environments for the earliest stages of mammalian embryo development. However, little is known about the mechanisms that…”
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Variable imprinting of the MEST gene in human preimplantation embryos by Huntriss, John D, Hemmings, Karen E, Hinkins, Matthew, Rutherford, Anthony J, Sturmey, Roger G, Elder, Kay, Picton, Helen M

“…There is evidence that expression and methylation of the imprinted paternally expressed gene 1/mesoderm-specific transcript homologue (PEG1/MEST) gene may be…”
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Human embryos from overweight and obese women display phenotypic and metabolic abnormalities by Leary, Christine, Leese, Henry J., Sturmey, Roger G.

“…STUDY QUESTION Is the developmental timing and metabolic regulation disrupted in embryos from overweight or obese women? SUMMARY ANSWER Oocytes from overweight…”
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Metabolic profile of in vitro derived human embryos is not affected by the mode of fertilization by Leary, Christine, Sturmey, Roger G

“…Abstract The pattern of metabolism by early embryos in vitro has been linked to a range of phenotypes, including viability. However, the extent to which…”
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Determinants of thermal homeostasis in the preimplantation embryo: a role for the embryo’s central heating system? by Leese, Henry J., Sturmey, Roger G.

“…A number of factors may impinge on thermal homeostasis in the early embryo. The most obvious is the ambient temperature in which development occurs…”
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Amino Acids and the Early Mammalian Embryo: Origin, Fate, Function and Life-Long Legacy by Leese, Henry J, McKeegan, Paul J, Sturmey, Roger G

“…Amino acids are now recognised as having multiple cellular functions in addition to their traditional role as constituents of proteins. This is…”
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Biological optimization, the Goldilocks principle, and how much is lagom in the preimplantation embryo by Leese, Henry J., Guerif, Fabrice, Allgar, Victoria, Brison, Daniel R., Lundin, Kersti, Sturmey, Roger G.

“…ABSTRACT The quiet embryo hypothesis postulates that early embryo viability is associated with a relatively low metabolism (Leese, 2002 BioEssays 24: 845–849)…”
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Changing the public perception of human embryology by Rivron, Nicolas C., Martinez-Arias, Alfonso, Sermon, Karen, Mummery, Christine, Schöler, Hans R., Wells, James, Nichols, Jenny, Hadjantonakis, Anna-Katerina, Lancaster, Madeline A., Moris, Naomi, Fu, Jianping, Sturmey, Roger G., Niakan, Kathy, Rossant, Janet, Kato, Kazuto

“…Human embryology is flourishing thanks to an impetus provided by embryo models formed from stem cells. These scientific advances require meticulous…”
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Metabolic heterogeneity during preimplantation development: the missing link? by Brison, Daniel R, Sturmey, Roger G, Leese, Henry J

“…Most tissues in the body rely on the presence of gap junctions in order to couple their component cells electrically and metabolically via intercellular…”
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Author Correction: Changing the public perception of human embryology by Rivron, Nicolas C., Martinez-Arias, Alfonso, Sermon, Karen, Mummery, Christine, Schöler, Hans R., Wells, James, Nichols, Jenny, Hadjantonakis, Anna-Katerina, Lancaster, Madeline A., Moris, Naomi, Fu, Jianping, Sturmey, Roger G., Niakan, Kathy, Rossant, Janet, Kato, Kazuto

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Effect of metabolic status on conceptus–maternal interactions on day 19 in dairy cattle: II. Effects on the endometrial transcriptome by Bauersachs, Stefan, Simintiras, Constantine A, Sturmey, Roger G, Krebs, Stefan, Bick, Jochen, Blum, Helmut, Wolf, Eckhard, Lonergan, Pat, Forde, Niamh

“…The aim of this study was to test the hypothesis that the metabolic stresses associated with lactation alter the ability of the endometrium to respond…”
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