Search Results - "Sturm, Dominik"

Pediatric Gliomas: Current Concepts on Diagnosis, Biology, and Clinical Management by Sturm, Dominik, Pfister, Stefan M, Jones, David T W

“…Gliomas are the most common CNS tumors in children and adolescents, and they show an extremely broad range of clinical behavior. The majority of pediatric…”
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DNA methylation-based classification and grading system for meningioma: a multicentre, retrospective analysis by Sahm, Felix, MD, Schrimpf, Daniel, PhD, Stichel, Damian, PhD, Jones, David T W, PhD, Hielscher, Thomas, MSc, Schefzyk, Sebastian, MSc, Okonechnikov, Konstantin, PhD, Koelsche, Christian, MD, Reuss, David E, MD, Capper, David, MD, Sturm, Dominik, MD, Wirsching, Hans-Georg, MD, Berghoff, Anna Sophie, MD, Baumgarten, Peter, MD, Kratz, Annekathrin, MD, Huang, Kristin, MD, Wefers, Annika K, MD, Hovestadt, Volker, PhD, Sill, Martin, PhD, Ellis, Hayley P, BSc, Kurian, Kathreena M, Prof, Okuducu, Ali Fuat, MD, Jungk, Christine, MD, Drueschler, Katharina, MD, Schick, Matthias, Bewerunge-Hudler, Melanie, PhD, Mawrin, Christian, Prof, Seiz-Rosenhagen, Marcel, Prof, Ketter, Ralf, Prof, Simon, Matthias, Prof, Westphal, Manfred, Prof, Lamszus, Katrin, Prof, Becker, Albert, Prof, Koch, Arend, MD, Schittenhelm, Jens, Prof, Rushing, Elisabeth J, Prof, Collins, V Peter, Prof, Brehmer, Stefanie, MD, Chavez, Lukas, PhD, Platten, Michael, Prof, Hänggi, Daniel, Prof, Unterberg, Andreas, Prof, Paulus, Werner, Prof, Wick, Wolfgang, Prof, Pfister, Stefan M, Prof, Mittelbronn, Michel, Prof, Preusser, Matthias, Prof, Herold-Mende, Christel, Prof, Weller, Michael, Prof, von Deimling, Andreas, Prof

“…Summary Background The WHO classification of brain tumours describes 15 subtypes of meningioma. Nine of these subtypes are allotted to WHO grade I, and three…”
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Reduced H3K27me3 and DNA Hypomethylation Are Major Drivers of Gene Expression in K27M Mutant Pediatric High-Grade Gliomas by Bender, Sebastian, Tang, Yujie, Lindroth, Anders M., Hovestadt, Volker, Jones, David T.W., Kool, Marcel, Zapatka, Marc, Northcott, Paul A., Sturm, Dominik, Wang, Wei, Radlwimmer, Bernhard, Højfeldt, Jonas W., Truffaux, Nathalène, Castel, David, Schubert, Simone, Ryzhova, Marina, Şeker-Cin, Huriye, Gronych, Jan, Johann, Pascal David, Stark, Sebastian, Meyer, Jochen, Milde, Till, Schuhmann, Martin, Ebinger, Martin, Monoranu, Camelia-Maria, Ponnuswami, Anitha, Chen, Spenser, Jones, Chris, Witt, Olaf, Collins, V. Peter, von Deimling, Andreas, Jabado, Nada, Puget, Stephanie, Grill, Jacques, Helin, Kristian, Korshunov, Andrey, Lichter, Peter, Monje, Michelle, Plass, Christoph, Cho, Yoon-Jae, Pfister, Stefan M.

“…Two recurrent mutations, K27M and G34R/V, within histone variant H3.3 were recently identified in ∼50% of pHGGs. Both mutations define clinically and…”
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Radiation-induced gliomas represent H3-/IDH-wild type pediatric gliomas with recurrent PDGFRA amplification and loss of CDKN2A/B by Deng, Maximilian Y., Sturm, Dominik, Pfaff, Elke, Sill, Martin, Stichel, Damian, Balasubramanian, Gnana Prakash, Tippelt, Stephan, Kramm, Christof, Donson, Andrew M., Green, Adam L., Jones, Chris, Schittenhelm, Jens, Ebinger, Martin, Schuhmann, Martin U., Jones, Barbara C., van Tilburg, Cornelis M., Wittmann, Andrea, Golanov, Andrey, Ryzhova, Marina, Ecker, Jonas, Milde, Till, Witt, Olaf, Sahm, Felix, Reuss, David, Sumerauer, David, Zamecnik, Josef, Korshunov, Andrey, von Deimling, Andreas, Pfister, Stefan M., Jones, David T. W.

“…Long-term complications such as radiation-induced second malignancies occur in a subset of patients following radiation-therapy, particularly relevant in…”
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Recurrent somatic mutations in ACVR1 in pediatric midline high-grade astrocytoma by Fontebasso, Adam M, Papillon-Cavanagh, Simon, Schwartzentruber, Jeremy, Nikbakht, Hamid, Gerges, Noha, Fiset, Pierre-Olivier, Bechet, Denise, Faury, Damien, De Jay, Nicolas, Ramkissoon, Lori A, Corcoran, Aoife, Jones, David T W, Sturm, Dominik, Johann, Pascal, Tomita, Tadanori, Goldman, Stewart, Nagib, Mahmoud, Bendel, Anne, Goumnerova, Liliana, Bowers, Daniel C, Leonard, Jeffrey R, Rubin, Joshua B, Alden, Tord, Browd, Samuel, Geyer, J Russell, Leary, Sarah, Jallo, George, Cohen, Kenneth, Gupta, Nalin, Prados, Michael D, Carret, Anne-Sophie, Ellezam, Benjamin, Crevier, Louis, Klekner, Almos, Bognar, Laszlo, Hauser, Peter, Garami, Miklos, Myseros, John, Dong, Zhifeng, Siegel, Peter M, Malkin, Hayley, Ligon, Azra H, Albrecht, Steffen, Pfister, Stefan M, Ligon, Keith L, Majewski, Jacek, Jabado, Nada, Kieran, Mark W

“…Nada Jabado and colleagues report identification of gain-of-function mutations in ACVR1 , which encodes activin A receptor type I, in midline pediatric…”
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K27M mutation in histone H3.3 defines clinically and biologically distinct subgroups of pediatric diffuse intrinsic pontine gliomas by Khuong-Quang, Dong-Anh, Buczkowicz, Pawel, Rakopoulos, Patricia, Liu, Xiao-Yang, Fontebasso, Adam M., Bouffet, Eric, Bartels, Ute, Albrecht, Steffen, Schwartzentruber, Jeremy, Letourneau, Louis, Bourgey, Mathieu, Bourque, Guillaume, Montpetit, Alexandre, Bourret, Genevieve, Lepage, Pierre, Fleming, Adam, Lichter, Peter, Kool, Marcel, von Deimling, Andreas, Sturm, Dominik, Korshunov, Andrey, Faury, Damien, Jones, David T., Majewski, Jacek, Pfister, Stefan M., Jabado, Nada, Hawkins, Cynthia

“…Pediatric glioblastomas (GBM) including diffuse intrinsic pontine gliomas (DIPG) are devastating brain tumors with no effective therapy. Here, we investigated…”
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BCAT1 promotes cell proliferation through amino acid catabolism in gliomas carrying wild-type IDH1 by Tönjes, Martje, Barbus, Sebastian, Park, Yoon Jung, Wang, Wei, Schlotter, Magdalena, Lindroth, Anders M, Pleier, Sabrina V, Bai, Alfa H C, Karra, Daniela, Piro, Rosario M, Felsberg, Jörg, Addington, Adele, Lemke, Dieter, Weibrecht, Irene, Hovestadt, Volker, Rolli, Claudio G, Campos, Benito, Turcan, Sevin, Sturm, Dominik, Witt, Hendrik, Chan, Timothy A, Herold-Mende, Christel, Kemkemer, Ralf, König, Rainer, Schmidt, Kathrin, Hull, William-Edmund, Pfister, Stefan M, Jugold, Manfred, Hutson, Susan M, Plass, Christoph, Okun, Jürgen G, Reifenberger, Guido, Lichter, Peter, Radlwimmer, Bernhard

“…Branched-chain amino acid transaminase 1, the enzyme that initiates the catabolism of branched-chain amino acids, is involved in glioma pathogenesis, making it…”
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A subset of pediatric-type thalamic gliomas share a distinct DNA methylation profile, H3K27me3 loss and frequent alteration of EGFR by Sievers, Philipp, Sill, Martin, Schrimpf, Daniel, Stichel, Damian, Reuss, David E, Sturm, Dominik, Hench, Jürgen, Frank, Stephan, Krskova, Lenka, Vicha, Ales, Zapotocky, Michal, Bison, Brigitte, Castel, David, Grill, Jacques, Debily, Marie-Anne, Harter, Patrick N, Snuderl, Matija, Kramm, Christof M, Reifenberger, Guido, Korshunov, Andrey, Jabado, Nada, Wesseling, Pieter, Wick, Wolfgang, Solomon, David A, Perry, Arie, Jacques, Thomas S, Jones, Chris, Witt, Olaf, Pfister, Stefan M, von Deimling, Andreas, Jones, David T W, Sahm, Felix

“…Abstract Background Malignant astrocytic gliomas in children show a remarkable biological and clinical diversity. Small in-frame insertions or missense…”
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Next-generation sequencing in routine brain tumor diagnostics enables an integrated diagnosis and identifies actionable targets by Sahm, Felix, Schrimpf, Daniel, Jones, David T. W., Meyer, Jochen, Kratz, Annekathrin, Reuss, David, Capper, David, Koelsche, Christian, Korshunov, Andrey, Wiestler, Benedikt, Buchhalter, Ivo, Milde, Till, Selt, Florian, Sturm, Dominik, Kool, Marcel, Hummel, Manuela, Bewerunge-Hudler, Melanie, Mawrin, Christian, Schüller, Ulrich, Jungk, Christine, Wick, Antje, Witt, Olaf, Platten, Michael, Herold-Mende, Christel, Unterberg, Andreas, Pfister, Stefan M., Wick, Wolfgang, von Deimling, Andreas

“…With the number of prognostic and predictive genetic markers in neuro-oncology steadily growing, the need for comprehensive molecular analysis of…”
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GOPC:ROS1 and other ROS1 fusions represent a rare but recurrent drug target in a variety of glioma types by Sievers, Philipp, Stichel, Damian, Sill, Martin, Schrimpf, Daniel, Sturm, Dominik, Selt, Florian, Ecker, Jonas, Kazdal, Daniel, Miele, Evelina, Kranendonk, Mariëtte E. G., Tops, Bastiaan B. J., Kohlhof-Meinecke, Patricia, Beschorner, Rudi, Kramm, Christof M., Hasselblatt, Martin, Reifenberger, Guido, Capper, David, Wesseling, Pieter, Stenzinger, Albrecht, Milde, Till, Korshunov, Andrey, Witt, Olaf, Pfister, Stefan M., Wick, Wolfgang, von Deimling, Andreas, Jones, David T. W., Sahm, Felix

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Primary mismatch repair deficient IDH-mutant astrocytoma (PMMRDIA) is a distinct type with a poor prognosis by Suwala, Abigail K., Stichel, Damian, Schrimpf, Daniel, Kloor, Matthias, Wefers, Annika K., Reinhardt, Annekathrin, Maas, Sybren L. N., Kratz, Christian P., Schweizer, Leonille, Hasselblatt, Martin, Snuderl, Matija, Abedalthagafi, Malak Sameer J., Abdullaev, Zied, Monoranu, Camelia M., Bergmann, Markus, Pekrun, Arnulf, Freyschlag, Christian, Aronica, Eleonora, Kramm, Christof M., Hinz, Felix, Sievers, Philipp, Korshunov, Andrey, Kool, Marcel, Pfister, Stefan M., Sturm, Dominik, Jones, David T. W., Wick, Wolfgang, Unterberg, Andreas, Hartmann, Christian, Dodgshun, Andrew, Tabori, Uri, Wesseling, Pieter, Sahm, Felix, von Deimling, Andreas, Reuss, David E.

“…Diffuse IDH-mutant astrocytoma mostly occurs in adults and carries a favorable prognosis compared to IDH-wildtype malignant gliomas. Acquired mismatch repair…”
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Distribution of TERT promoter mutations in pediatric and adult tumors of the nervous system by Koelsche, Christian, Sahm, Felix, Capper, David, Reuss, David, Sturm, Dominik, Jones, David T. W., Kool, Marcel, Northcott, Paul A., Wiestler, Benedikt, Böhmer, Katja, Meyer, Jochen, Mawrin, Christian, Hartmann, Christian, Mittelbronn, Michel, Platten, Michael, Brokinkel, Benjamin, Seiz, Marcel, Herold-Mende, Christel, Unterberg, Andreas, Schittenhelm, Jens, Weller, Michael, Pfister, Stefan, Wick, Wolfgang, Korshunov, Andrey, von Deimling, Andreas

“…Hot spot mutations in the promoter region of telomerase reverse transcriptase ( TERT ) have recently been described in several human tumor entities. These…”
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STENCIL-NET for equation-free forecasting from data by Maddu, Suryanarayana, Sturm, Dominik, Cheeseman, Bevan L., Müller, Christian L., Sbalzarini, Ivo F.

“…We present an artificial neural network architecture, termed STENCIL-NET, for equation-free forecasting of spatiotemporal dynamics from data. STENCIL-NET works…”
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Comprehensive Analysis of Chromatin States in Atypical Teratoid/Rhabdoid Tumor Identifies Diverging Roles for SWI/SNF and Polycomb in Gene Regulation by Erkek, Serap, Johann, Pascal D., Finetti, Martina A., Drosos, Yiannis, Chou, Hsien-Chao, Zapatka, Marc, Sturm, Dominik, Jones, David T.W., Korshunov, Andrey, Rhyzova, Marina, Wolf, Stephan, Mallm, Jan-Philipp, Beck, Katja, Witt, Olaf, Kulozik, Andreas E., Frühwald, Michael C., Northcott, Paul A., Korbel, Jan O., Lichter, Peter, Eils, Roland, Gajjar, Amar, Roberts, Charles W.M., Williamson, Daniel, Hasselblatt, Martin, Chavez, Lukas, Pfister, Stefan M., Kool, Marcel

“…Biallelic inactivation of SMARCB1, encoding a member of the SWI/SNF chromatin remodeling complex, is the hallmark genetic aberration of atypical teratoid…”
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Mutations in SETD2 and genes affecting histone H3K36 methylation target hemispheric high-grade gliomas by Fontebasso, Adam M., Schwartzentruber, Jeremy, Khuong-Quang, Dong-Anh, Liu, Xiao-Yang, Sturm, Dominik, Korshunov, Andrey, Jones, David T. W., Witt, Hendrik, Kool, Marcel, Albrecht, Steffen, Fleming, Adam, Hadjadj, Djihad, Busche, Stephan, Lepage, Pierre, Montpetit, Alexandre, Staffa, Alfredo, Gerges, Noha, Zakrzewska, Magdalena, Zakrzewski, Krzystof, Liberski, Pawel P., Hauser, Peter, Garami, Miklos, Klekner, Almos, Bognar, Laszlo, Zadeh, Gelareh, Faury, Damien, Pfister, Stefan M., Jabado, Nada, Majewski, Jacek

“…Recurrent mutations affecting the histone H3.3 residues Lys27 or indirectly Lys36 are frequent drivers of pediatric high-grade gliomas (over 30 % of HGGs). To…”
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PATZ1 fusions define a novel molecularly distinct neuroepithelial tumor entity with a broad histological spectrum by Alhalabi, Karam T., Stichel, Damian, Sievers, Philipp, Peterziel, Heike, Sommerkamp, Alexander C., Sturm, Dominik, Wittmann, Andrea, Sill, Martin, Jäger, Natalie, Beck, Pengbo, Pajtler, Kristian W., Snuderl, Matija, Jour, George, Delorenzo, Michael, Martin, Allison M., Levy, Adam, Dalvi, Nagma, Hansford, Jordan R., Gottardo, Nicholas G., Uro-Coste, Emmanuelle, Maurage, Claude-Alain, Godfraind, Catherine, Vandenbos, Fanny, Pietsch, Torsten, Kramm, Christof, Filippidou, Maria, Kattamis, Antonis, Jones, Chris, Øra, Ingrid, Mikkelsen, Torben Stamm, Zapotocky, Michal, Sumerauer, David, Scheie, David, McCabe, Martin, Wesseling, Pieter, Tops, Bastiaan B. J., Kranendonk, Mariëtte E. G., Karajannis, Matthias A., Bouvier, Nancy, Papaemmanuil, Elli, Dohmen, Hildegard, Acker, Till, von Hoff, Katja, Schmid, Simone, Miele, Evelina, Filipski, Katharina, Kitanovski, Lidija, Krskova, Lenka, Gojo, Johannes, Haberler, Christine, Alvaro, Frank, Ecker, Jonas, Selt, Florian, Milde, Till, Witt, Olaf, Oehme, Ina, Kool, Marcel, von Deimling, Andreas, Korshunov, Andrey, Pfister, Stefan M., Sahm, Felix, Jones, David T. W.

“…Large-scale molecular profiling studies in recent years have shown that central nervous system (CNS) tumors display a much greater heterogeneity in terms of…”
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Recurrent fusions in PLAGL1 define a distinct subset of pediatric-type supratentorial neuroepithelial tumors by Sievers, Philipp, Henneken, Sophie C., Blume, Christina, Sill, Martin, Schrimpf, Daniel, Stichel, Damian, Okonechnikov, Konstantin, Reuss, David E., Benzel, Julia, Maaß, Kendra K., Kool, Marcel, Sturm, Dominik, Zheng, Tuyu, Ghasemi, David R., Kohlhof-Meinecke, Patricia, Cruz, Ofelia, Suñol, Mariona, Lavarino, Cinzia, Ruf, Viktoria, Boldt, Henning B., Pagès, Mélanie, Pouget, Celso, Schweizer, Leonille, Kranendonk, Mariëtte E. G., Akhtar, Noreen, Bunkowski, Stephanie, Stadelmann, Christine, Schüller, Ulrich, Mueller, Wolf C., Dohmen, Hildegard, Acker, Till, Harter, Patrick N., Mawrin, Christian, Beschorner, Rudi, Brandner, Sebastian, Snuderl, Matija, Abdullaev, Zied, Aldape, Kenneth, Gilbert, Mark R., Armstrong, Terri S., Ellison, David W., Capper, David, Ichimura, Koichi, Reifenberger, Guido, Grundy, Richard G., Jabado, Nada, Krskova, Lenka, Zapotocky, Michal, Vicha, Ales, Varlet, Pascale, Wesseling, Pieter, Rutkowski, Stefan, Korshunov, Andrey, Wick, Wolfgang, Pfister, Stefan M., Jones, David T. W., von Deimling, Andreas, Pajtler, Kristian W., Sahm, Felix

“…Ependymomas encompass a heterogeneous group of central nervous system (CNS) neoplasms that occur along the entire neuroaxis. In recent years, extensive…”
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Integrated DNA methylation and copy-number profiling identify three clinically and biologically relevant groups of anaplastic glioma by Wiestler, Benedikt, Capper, David, Sill, Martin, Jones, David T. W., Hovestadt, Volker, Sturm, Dominik, Koelsche, Christian, Bertoni, Anna, Schweizer, Leonille, Korshunov, Andrey, Weiß, Elisa K., Schliesser, Maximilian G., Radbruch, Alexander, Herold-Mende, Christel, Roth, Patrick, Unterberg, Andreas, Hartmann, Christian, Pietsch, Torsten, Reifenberger, Guido, Lichter, Peter, Radlwimmer, Bernhard, Platten, Michael, Pfister, Stefan M., von Deimling, Andreas, Weller, Michael, Wick, Wolfgang

“…The outcome of patients with anaplastic gliomas varies considerably. Whether a molecular classification of anaplastic gliomas based on large-scale genomic or…”
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Chromatin Remodeling Defects in Pediatric and Young Adult Glioblastoma: A Tale of a Variant Histone 3 Tail by Fontebasso, Adam M., Liu, Xiao-Yang, Sturm, Dominik, Jabado, Nada

“…Primary brain tumors occur in 8 out of 100 000 people and are the leading cause of cancer‐related death in children. Among brain tumors, high‐grade…”
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Evidence of H3 K27M mutations in posterior fossa ependymomas by Gessi, Marco, Capper, David, Sahm, Felix, Huang, Kristin, von Deimling, Andreas, Tippelt, Stephan, Fleischhack, Gudrun, Scherbaum, Daniel, Alfer, Joachim, Juhnke, Björn-Ole, von Hoff, Katja, Rutkowski, Stefan, Warmuth-Metz, Monika, Chavez, Lukas, Pfister, Stefan M., Pietsch, Torsten, Jones, David T. W., Sturm, Dominik

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