Search Results - "Sturgeon, Christopher"

Wnt signaling controls the specification of definitive and primitive hematopoiesis from human pluripotent stem cells by Sturgeon, Christopher M, Ditadi, Andrea, Awong, Geneve, Kennedy, Marion, Keller, Gordon

“…Hematopoietic differentiation of human pluripotent stem cells is directed to either the definitive or primitive program, a step toward the generation of…”
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A view of human haematopoietic development from the Petri dish by Ditadi, Andrea, Sturgeon, Christopher M., Keller, Gordon

“…Key Points Human pluripotent stem cells (hPSCs) provide outstanding new opportunities to study human haematopoietic development and blood cell disease…”
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T Lymphocyte Potential Marks the Emergence of Definitive Hematopoietic Progenitors in Human Pluripotent Stem Cell Differentiation Cultures by Kennedy, Marion, Awong, Geneve, Sturgeon, Christopher M., Ditadi, Andrea, LaMotte-Mohs, Ross, Zúñiga-Pflücker, Juan Carlos, Keller, Gordon

“…The efficient generation of hematopoietic stem cells from human pluripotent stem cells is dependent on the appropriate specification of the definitive…”
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Directed differentiation of definitive hemogenic endothelium and hematopoietic progenitors from human pluripotent stem cells by Ditadi, Andrea, Sturgeon, Christopher M.

“…•hPSCs can be differentiated towards hematopoietic cell fates.•Primitive erythro-myeloid progenitors can be obtained by stage-specific Wnt…”
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Generation of functionally distinct hemogenic endothelial cell populations from pluripotent stem cells by Luff, Stephanie A., Fernandez, Nestor A., Sturgeon, Christopher M., Ditadi, Andrea

“…A diverse array of protocols have been established for the directed differentiation of human pluripotent stem cells (hPSCs) into a variety of cell types,…”
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Potently Cytotoxic Natural Killer Cells Initially Emerge from Erythro-Myeloid Progenitors during Mammalian Development by Dege, Carissa, Fegan, Katherine H., Creamer, J. Philip, Berrien-Elliott, Melissa M., Luff, Stephanie A., Kim, Darren, Wagner, Julia A., Kingsley, Paul D., McGrath, Kathleen E., Fehniger, Todd A., Palis, James, Sturgeon, Christopher M.

“…Natural killer (NK) cells are a critical component of the innate immune system. However, their ontogenic origin has remained unclear. Here, we report that NK…”
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Human definitive haemogenic endothelium and arterial vascular endothelium represent distinct lineages by Ditadi, Andrea, Sturgeon, Christopher M., Tober, Joanna, Awong, Geneve, Kennedy, Marion, Yzaguirre, Amanda D., Azzola, Lisa, Ng, Elizabeth S., Stanley, Edouard G., French, Deborah L., Cheng, Xin, Gadue, Paul, Speck, Nancy A., Elefanty, Andrew G., Keller, Gordon

“…The generation of haematopoietic stem cells (HSCs) from human pluripotent stem cells (hPSCs) will depend on the accurate recapitulation of embryonic…”
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Back to the future: lessons from development drive innovation of human pluripotent stem cell therapies by Ditadi, Andrea, Sturgeon, Christopher M.

“…•Leaders in hPSC-derived hematopoiesis met in Seattle, Washington, for a 1-day symposium.•hPSC-based blood disease modeling allows identification of new…”
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Haematopoietic stem and progenitor cell heterogeneity is inherited from the embryonic endothelium by Ghersi, Joey J., Baldissera, Gabriel, Hintzen, Jared, Luff, Stephanie A., Cheng, Siyuan, Xia, Ivan Fan, Sturgeon, Christopher M., Nicoli, Stefania

“…Definitive haematopoietic stem and progenitor cells (HSPCs) generate erythroid, lymphoid and myeloid lineages. HSPCs are produced in the embryo via…”
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Posttranscriptional modulation of TERC by PAPD5 inhibition rescues hematopoietic development in dyskeratosis congenita by Fok, Wilson Chun, Shukla, Siddharth, Vessoni, Alexandre Teixeira, Brenner, Kirsten Ann, Parker, Roy, Sturgeon, Christopher M., Batista, Luis Francisco Zirnberger

“…Reduced levels of TERC, the telomerase RNA component, cause dyskeratosis congenita (DC) in patients harboring mutations in TERC, PARN, NOP10, NHP2, NAF1, or…”
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Directed Differentiation of Primitive and Definitive Hematopoietic Progenitors from Human Pluripotent Stem Cells by Dege, Carissa, Sturgeon, Christopher M

“…One of the major goals for regenerative medicine is the generation and maintenance of hematopoietic stem cells (HSCs) derived from human pluripotent stem cells…”
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Identification of a retinoic acid-dependent haemogenic endothelial progenitor from human pluripotent stem cells by Luff, Stephanie A., Creamer, J. Philip, Valsoni, Sara, Dege, Carissa, Scarfò, Rebecca, Dacunto, Analisa, Cascione, Sara, Randolph, Lauren N., Cavalca, Eleonora, Merelli, Ivan, Morris, Samantha A., Ditadi, Andrea, Sturgeon, Christopher M.

“…The generation of haematopoietic stem cells (HSCs) from human pluripotent stem cells (hPSCs) is a major goal for regenerative medicine. During embryonic…”
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Defining the path to hematopoietic stem cells by Sturgeon, Christopher M, Ditadi, Andrea, Clarke, Raedun L, Keller, Gordon

“…New insights into hemogenic endothelium will facilitate efforts to produce hematopoietic stem cells in vitro …”
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CD32 captures committed haemogenic endothelial cells during human embryonic development by Scarfò, Rebecca, Randolph, Lauren N., Abou Alezz, Monah, El Khoury, Mahassen, Gersch, Amélie, Li, Zhong-Yin, Luff, Stephanie A., Tavosanis, Andrea, Ferrari Ramondo, Giulia, Valsoni, Sara, Cascione, Sara, Didelon, Emma, Passerini, Laura, Amodio, Giada, Brandas, Chiara, Villa, Anna, Gregori, Silvia, Merelli, Ivan, Freund, Jean-Noël, Sturgeon, Christopher M., Tavian, Manuela, Ditadi, Andrea

“…During embryonic development, blood cells emerge from specialized endothelial cells, named haemogenic endothelial cells (HECs). As HECs are rare and only…”
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CD1d expression demarcates CDX4+ hemogenic mesoderm with definitive hematopoietic potential by Philip Creamer, J., Luff, Stephanie A., Yu, Hao, Sturgeon, Christopher M.

“…•scRNAseq of early hPSC differentiation reveals a CDX1/2/4+CD1d + mesodermal population.•KDR + CD1d + mesoderm efficiently gives rise to hemogenic endothelium…”
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Derivation of extra-embryonic and intra-embryonic macrophage lineages from human pluripotent stem cells by Bredemeyer, Andrea L, Amrute, Junedh M, Koenig, Andrew L, Idol, Rachel A, He, Li, Luff, Stephanie A, Dege, Carissa, Leid, Jamison M, Schilling, Joel D, Hinson, J Travis, Dinauer, Mary C, Sturgeon, Christopher M, Lavine, Kory J

“…Tissue-resident macrophages are increasingly recognized as important determinants of organ homeostasis, tissue repair, remodeling and regeneration. Although…”
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Let Me Speak! A Reviewers’ Guide to Writing a Successful Meeting Abstract by Sturgeon, Christopher M., Ditadi, Andrea

“…Being able to summarize properly your work is not an easy task. But learning the skill of writing a good abstract is very important, as it can open many doors,…”
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Chemical inhibition of PAPD5/7 rescues telomerase function and hematopoiesis in dyskeratosis congenita by Shukla, Siddharth, Jeong, Ho-Chang, Sturgeon, Christopher M., Parker, Roy, Batista, Luis Francisco Zirnberger

“…Dyskeratosis congenita (DC) is a pediatric bone marrow failure syndrome caused by germline mutations in telomere biology genes. Mutations in DKC1 (the most…”
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Altered erythropoiesis via JAK2 and ASXL1 mutations in myeloproliferative neoplasms by Collins, Taylor B., Laranjeira, Angelo B.A., Kong, Tim, Fulbright, Mary C., Fisher, Daniel A.C., Sturgeon, Christopher M., Batista, Luis F.Z., Oh, Stephen T.

“…•JAK2 and ASXL1 mutations inflict opposing regulation of erythropoiesis.•Mutant ASXL1 upregulates PRMT6.•PRMT6 inhibition specifically augments disease burden…”
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Human definitive hematopoietic specification from pluripotent stem cells is regulated by mesodermal expression of CDX4 by Creamer, J.Philip, Dege, Carissa, Ren, Qihao, Ho, Jolie T.K., Valentine, Mark C., Druley, Todd E., Sturgeon, Christopher M.

“…The generation of hematopoietic stem cells from human pluripotent stem cells (hPSCs) is a major goal for regenerative medicine. Achieving this goal is…”
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