Search Results - "Sturdy, Megan"

X‐ray structural studies of quinone reductase 2 nanomolar range inhibitors by Pegan, Scott D., Sturdy, Megan, Ferry, Gilles, Delagrange, Philippe, Boutin, Jean A., Mesecar, Andrew D.

“…Quinone reductase 2 (QR2) is one of two members comprising the mammalian quinone reductase family of enzymes responsible for performing FAD mediated reductions…”
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Strongylophorines: Natural Product Inhibitors of Hypoxia-Inducible Factor-1 Transcriptional Pathway by Mohammed, Kaleem A, Jadulco, Raquel C, Bugni, Tim S, Harper, Mary Kay, Sturdy, Megan, Ireland, Chris M

“…Rapidly increasing experimental and clinical data provides evidence for the role of hypoxia inducible factor-1 (HIF-1) as a crucial mediator of tumor survival…”
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Metabolic stress, reactive oxygen species, and arrhythmia by Jeong, Euy-Myoung, Liu, Man, Sturdy, Megan, Gao, Ge, Varghese, Susan T, Sovari, Ali A, Dudley, Samuel C

“…Abstract Cardiac arrhythmias can cause sudden cardiac death (SCD) and add to the current heart failure (HF) health crisis. Nevertheless, the pathological…”
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Factors Influencing Incidence of Supraventricular Arrhythmias during and after Autologous Stem Cell Transplant in Multiple Myeloma by Sturdy, Megan, Ye, Rebecca, Jenkins, Trevor L, Driscoll, James, Caimi, Paolo, Metheny, Leland, Zebrowski, Rachel, Ferrari, Nicole, Kolk, Merle, de Lima, Marcos, Malek, Ehsan

“…Multiple Myeloma (MM) are often treated with high-dose melphalan and autologous stem cell transplant (ASCT), followed by maintenance therapy (McCarthy et al…”
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Eucapsitrione, an Anti-Mycobacterium tuberculosis Anthraquinone Derivative from the Cultured Freshwater Cyanobacterium Eucapsis sp by Sturdy, Megan, Krunic, Aleksej, Cho, Sanghyun, Franzblau, Scott, Orjala, Jimmy

“…Eucapsitrione (1), an anthraquinone derivative with an indeno-anthracene-trione skeleton, was isolated from the cyanobacterium Eucapsis sp. (UTEX 1519) by…”
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Diastolic dysfunction is associated with cardiac fibrosis in the senescence-accelerated mouse by Reed, Alana L, Tanaka, Atsuko, Sorescu, Dan, Liu, Hong, Jeong, Euy-Myoung, Sturdy, Megan, Walp, Erik R, Dudley, Jr, Samuel C, Sutliff, Roy L

“…Diastolic heart failure is a major cause of mortality in the elderly population. It is often preceded by diastolic dysfunction, which is characterized by…”
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Minutissamides E–L, antiproliferative cyclic lipodecapeptides from the cultured freshwater cyanobacterium cf. Anabaena sp by Kang, Hahk-Soo, Sturdy, Megan, Krunic, Aleksej, Kim, Hyunjung, Shen, Qi, Swanson, Steven M., Orjala, Jimmy

“…The extract of UIC 10035, a strain obtained from a sample collected near the town of Homestead, South Florida, showed antiproliferative activity against…”
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Screening Natural Products for Inhibitors of Quinone Reductase-2 Using Ultrafiltration LC−MS by Choi, Yongsoo, Jermihov, Katherine, Nam, Sang-Jip, Sturdy, Megan, Maloney, Katherine, Qiu, Xi, Chadwick, Lucas R, Main, Matthew, Chen, Shao-Nong, Mesecar, Andrew D, Farnsworth, Norman R, Pauli, Guido F, Fenical, William, Pezzuto, John M, van Breemen, Richard B

“…Inhibitors of quinone reductase-2 (NQO2; QR-2) can have antimalarial activity and antitumor activities or can function as chemoprevention agents by preventing…”
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Abstract 17209: Diabetes Mellitus Potentially Can Cause Diastolic Dysfunction by Sturdy, Megan, Jeong, Euy-Myoung, Dudley, Samuel C

“…Abstract only Introduction: Diastolic dysfunction (DD) is observed in about 40% of patients with diabetes mellitus (DM). DM is associated with DD in…”
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Synthesis of Casimiroin and Optimization of Its Quinone Reductase 2 and Aromatase Inhibitory Activities by Maiti, Arup, Reddy, P. V. Narasimha, Sturdy, Megan, Marler, Laura, Pegan, Scott D, Mesecar, Andrew D, Pezzuto, John M, Cushman, Mark

“…An efficient method has been developed to synthesize casimiroin (1), a component of the edible fruit of Casimiroa edulis, on a multigram scale in good overall…”
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Cylindrocyclophanes with Proteasome Inhibitory Activity from the Cyanobacterium Nostoc sp by Chlipala, George E, Sturdy, Megan, Krunic, Aleksej, Lantvit, Daniel D, Shen, Qi, Porter, Kyle, Swanson, Steven M, Orjala, Jimmy

“…Material collected from a parkway in the city of Chicago afforded the isolation of a Nostoc species (UIC 10022A). The extract of this strain displayed…”
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Bioactive Compounds from the Fern Lepisorus contortus by Yang, Jian-Hong, Kondratyuk, Tamara P, Jermihov, Katherine C, Marler, Laura E, Qiu, Xi, Choi, Yongsoo, Cao, Hongmei, Yu, Rui, Sturdy, Megan, Huang, Rong, Liu, Ying, Wang, Li-Qin, Mesecar, Andrew D, van Breemen, Richard B, Pezzuto, John, M, Fong, Harry H. S, Chen, Ye-Gao, Zhang, Hong-Jie

“…Phytochemical investigation of the whole plant of Lepisorus contortus (Christ) Ching led to the isolation of five new phenylethanoid glycosides (1−5), each…”
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CYANOS: A Data Management System for Natural Product Drug Discovery Efforts Using Cultured Microorganisms by Chlipala, George E, Krunic, Aleksej, Mo, Shunyan, Sturdy, Megan, Orjala, Jimmy

“…A software package, termed “CYANOS”, has been developed to facilitate the data management and mining for natural product drug discovery efforts. This system…”
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Isolation and evaluation of kaempferol glycosides from the fern Neocheiropteris palmatopedata by Yang, Jian-Hong, Kondratyuk, Tamara P., Marler, Laura E., Qiu, Xi, Choi, Yongsoo, Cao, Hongmei, Yu, Rui, Sturdy, Megan, Pegan, Scott, Liu, Ying, Wang, Li-Qin, Mesecar, Andrew D., Breemen, Richard B. Van, Pezzuto, John M., Fong, Harry H.S., Chen, Ye-Gao, Zhang, Hong-Jie

“…Six kaempferol glycosides including three hitherto unknown compounds (1–3) were isolated from the roots of the fern Neocheiropteris palmatopedata. Compounds 1…”
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Natural Product Drug Discovery Regarding Mycobacterium tuberculosis and Quinone Reductase 2 by Sturdy, Megan

“…Natural Products are a significant source of lead compounds that either are drugs or can be synthetically generated and modified to be drugs for the…”
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Correction to Screening Natural Products for Inhibitors of Quinone Reductase-2 Using Ultrafiltration LC–MS by Choi, Yongsoo, Jermihov, Katherine, Nam, Sang-Jip, Sturdy, Megan, Maloney, Katherine, Qiu, Xi, Chadwick, Lucas R, Main, Matthew, Chen, Shao-Nong, Mesecar, Andrew D, Farnsworth, Norman R, Pauli, Guido F, Fenical, William, Pezzuto, John M, van Breemen, Richard B

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Intermolecular reductive coupling of hindered N-aryl imines towards the modular synthesis of chiral N-heterocyclic carbenes by Mercer, Gregory J., Sturdy, Megan, Jensen, David R., Sigman, Matthew S.

“…We describe a simple method for the synthesis of hindered N-aryl diamines. The diastereoselectivity for these processes are relatively low but the diamines can…”
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Risk Model to Predict Supraventricular Arrhythmias in Multiple Myeloma Patients Undergoing Autologous Stem Cell Transplant by Knaggs, Mike, Sturdy, Megan, Ye, Rebecca, Caimi, Paolo, Metheny, Leland, Kolk, Merle, Ferrari, Nicole, Zebrowski, Rachel, de Lima, Marcos, Malek, Ehsan

“…Multiple Myeloma (MM) are often treated with high-dose melphalan and autologous stem cell transplant (ASCT). Cardiac toxicity, including Supraventricular…”
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