Search Results - "Sturdy, Jacob"
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1
A guide to uncertainty quantification and sensitivity analysis for cardiovascular applications
Published in International journal for numerical methods in biomedical engineering (01-08-2016)“…Summary As we shift from population‐based medicine towards a more precise patient‐specific regime guided by predictions of verified and well‐established…”
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2
Parameter estimation for closed-loop lumped parameter models of the systemic circulation using synthetic data
Published in Mathematical biosciences (01-01-2022)“…Physics-based models can be applied to describe mechanisms in both health and disease, which has the potential to accelerate the development of personalized…”
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3
Examining temporal changes in model-optimized parameters using longitudinal hemodynamic measurements
Published in Biomedical engineering online (10-07-2024)“…We previously applied hemodynamic data to personalize a mathematical model of the circulation expressed as physically interpretable parameters. The aim of this…”
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4
Monitoring variability in parameter estimates for lumped parameter models of the systemic circulation using longitudinal hemodynamic measurements
Published in Biomedical engineering online (13-04-2023)“…Physics-based cardiovascular models are only recently being considered for disease diagnosis or prognosis in clinical settings. These models depend on…”
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5
Modeling the afferent dynamics of the baroreflex control system
Published in PLoS computational biology (01-12-2013)“…In this study we develop a modeling framework for predicting baroreceptor firing rate as a function of blood pressure. We test models within this framework…”
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6
Age and sex-dependent sensitivity analysis of a common carotid artery model
Published in Biomechanics and modeling in mechanobiology (01-06-2024)“…The common carotid artery (CCA) is an accessible and informative site for assessing cardiovascular function which makes it a prime candidate for clinically…”
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7
Global sensitivity analysis with multifidelity Monte Carlo and polynomial chaos expansion for vascular haemodynamics
Published in International journal for numerical methods in biomedical engineering (01-08-2024)“…Computational models of the cardiovascular system are increasingly used for the diagnosis, treatment, and prevention of cardiovascular disease. Before being…”
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8
Machine learning augmented reduced-order models for FFR-prediction
Published in Computer methods in applied mechanics and engineering (01-10-2021)“…Computational predictions in cardiovascular medicine have largely relied on explicit models derived from physical and physiological principles. Recently, the…”
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9
Effect of side branch flow upon physiological indices in coronary artery disease
Published in Journal of biomechanics (16-04-2020)“…Recent efforts have demonstrated the ability of computational models to predict fractional flow reserve from coronary artery imaging without the need for…”
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10
Evaluating the precision and reproducibility of non-invasive deformation measurements in an arterial phantom
Published in Measurement : journal of the International Measurement Confederation (01-07-2023)“…Computer modeling combined with non-invasive measurement modalities may provide a means to advanced diagnosis and treatment of cardiovascular diseases;…”
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11
Uncertainty Quantification and Sensitivity Analysis for Computational FFR Estimation in Stable Coronary Artery Disease
Published in Cardiovascular engineering and technology (01-12-2018)“…Purpose The main objectives of this study are to validate a reduced-order model for the estimation of the fractional flow reserve (FFR) index based on blood…”
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12
Modeling the differentiation of A- and C-type baroreceptor firing patterns
Published in Journal of computational neuroscience (01-02-2017)“…The baroreceptor neurons serve as the primary transducers of blood pressure for the autonomic nervous system and are thus critical in enabling the body to…”
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13
Modeling the Afferent Dynamics of the Baroreflex Control System: e1003384
Published in PLoS computational biology (01-12-2013)“…In this study we develop a modeling framework for predicting baroreceptor firing rate as a function of blood pressure. We test models within this framework…”
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14
Uncertainty quantification of computational coronary stenosis assessment and model based mitigation of image resolution limitations
Published in Journal of computational science (01-02-2019)“…•The effects of clinically relevant uncertainties on the prediction of FFR are quantified.•The effects of limitations in medical imaging are assessed and a new…”
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15
Global sensitivity analysis with multifidelity Monte Carlo and polynomial chaos expansion for carotid artery haemodynamics
Published 09-01-2024“…Computational models of the cardiovascular system are increasingly used for the diagnosis, treatment, and prevention of cardiovascular disease. Before being…”
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16
Modeling the differentiation of A- and C-type baroreceptor firing patterns
Published 07-09-2016“…Journal of Computational Neuroscience, 2016 The baroreceptor neurons serve as the primary transducers of blood pressure for the autonomic nervous system and…”
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