Search Results - "Stupia, Simone"
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Vaccination With a FAT1-Derived B Cell Epitope Combined With Tumor-Specific B and T Cell Epitopes Elicits Additive Protection in Cancer Mouse Models
Published in Frontiers in oncology (26-10-2018)“…Human FAT1 is overexpressed on the surface of most colorectal cancers (CRCs) and in particular a 25 amino acid sequence (D8) present in one of the 34 cadherin…”
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Innate immune receptor signaling induces transient melanoma dedifferentiation while preserving immunogenicity
Published in Journal for immunotherapy of cancer (01-06-2022)“…BackgroundImmune-stimulatory agents, like agonists of the innate immune receptor RIG-I, are currently tested in clinical trials as an intratumoral treatment…”
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Bacterial outer membrane vesicles engineered with lipidated antigens as a platform for Staphylococcus aureus vaccine
Published in Proceedings of the National Academy of Sciences - PNAS (22-10-2019)“…Bacterial outer membrane vesicles (OMVs) represent an interesting vaccine platform for their built-in adjuvanticity and simplicity of production process…”
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HLA Class II Loss and JAK1/2 Deficiency Coevolve in Melanoma Leading to CD4 T-cell and IFNγ Cross-Resistance
Published in Clinical cancer research (01-08-2023)“…Recent studies have demonstrated HLA class II (HLA-II)-dependent killing of melanoma cells by cytotoxic CD4 T cells. We investigated evolution of HLA-II-loss…”
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Melanoma Differentiation Trajectories Determine Sensitivity toward Pre-Existing CD8+ Tumor-Infiltrating Lymphocytes
Published in Journal of investigative dermatology (01-10-2021)“…The highly plastic nature of melanoma enables its transition among diverse cell states to survive hostile conditions. However, the interplay between specific…”
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Melanoma differentiation trajectories determine sensitivity towards pre-existing CD8 + tumor-infiltrating lymphocytes
Published in Journal of investigative dermatology (30-03-2021)“…The highly plastic nature of melanoma enables its transition among diverse cell states to survive hostile conditions. However, the interplay between specific…”
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