Search Results - "Stunz, Laura L."

CD40 and autoimmunity: The dark side of a great activator by Peters, Anna L, Stunz, Laura L, Bishop, Gail A

“…Abstract CD40 is a tumor necrosis factor receptor superfamily member expressed by immune and non-immune cells. CD40:CD154 interactions mediate T-dependent B…”
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TRAF3 as a Multifaceted Regulator of B Lymphocyte Survival and Activation by Bishop, Gail A, Stunz, Laura L, Hostager, Bruce S

“…The adaptor protein TNF receptor-associated factor 3 (TRAF3) serves as a powerful negative regulator in multiple aspects of B cell biology. Early studies in…”
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Tumor Necrosis Factor Receptor-Associated Factor 3 Is a Critical Regulator of B Cell Homeostasis in Secondary Lymphoid Organs by Xie, Ping, Stunz, Laura L., Larison, Karen D., Yang, Baoli, Bishop, Gail A.

“…Tumor necrosis factor receptor-associated factor 3 (TRAF3) is an adaptor protein that directly binds to a number of receptors of the tumor necrosis factor…”
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Epstein-Barr Functional Mimicry: Pathogenicity of Oncogenic Latent Membrane Protein-1 in Systemic Lupus Erythematosus and Autoimmunity by Munroe, Melissa E, Anderson, Jourdan R, Gross, Timothy F, Stunz, Laura L, Bishop, Gail A, James, Judith A

“…Systemic lupus erythematosus (SLE) and other autoimmune diseases are propelled by immune dysregulation and pathogenic, disease-specific autoantibodies…”
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Nuclear TRAF3 is a negative regulator of CREB in B cells by Mambetsariev, Nurbek, Lin, Wai W., Stunz, Laura L., Hanson, Brett M., Hildebrand, Joanne M., Bishop, Gail A.

“…The adaptor protein TNF receptor-associated factor 3 (TRAF3) regulates signaling through B-lymphocyte receptors, including CD40, BAFF receptor, and Toll-like…”
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Roles for TNF-receptor associated factor 3 (TRAF3) in lymphocyte functions by Yi, Zuoan, Lin, Wai Wai, Stunz, Laura L, Bishop, Gail A

“…Abstract TRAF3 is an adapter protein that serves and regulates the functions of several types of receptors, located both inside the cell and at the plasma…”
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Roles of tumor necrosis factor receptor associated factor 3 (TRAF3) and TRAF5 in immune cell functions by Hildebrand, Joanne M., Yi, Zuoan, Buchta, Claire M., Poovassery, Jayakumar, Stunz, Laura L., Bishop, Gail A.

“…A large and diverse group of receptors utilizes the family of cytoplasmic signaling proteins known as tumor necrosis factor receptor (TNFR)‐associated factors…”
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TRAF3 regulates the oncogenic proteins Pim2 and c-Myc to restrain survival in normal and malignant B cells by Whillock, Amy L., Mambetsariev, Nurbek, Lin, Wai W., Stunz, Laura L., Bishop, Gail A.

“…TRAF3 is a versatile intracellular adapter protein with multiple context-specific roles. Uniquely in B cells, TRAF3 deficiency enhances survival and increases…”
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The adaptor protein TRAF3 inhibits interleukin-6 receptor signaling in B cells to limit plasma cell development by Lin, Wai W, Yi, Zuoan, Stunz, Laura L, Maine, Christian J, Sherman, Linda A, Bishop, Gail A

“…Tumor necrosis factor receptor-associated factor 3 (TRAF3) is an adaptor protein that inhibits signaling by CD40 and by the receptor for B cell-activating…”
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CD40 Signaling in Mice Elicits a Broad Antiviral Response Early during Acute Infection with RNA Viruses by Rogers, Kai J, Richards, Paige T, Zacharias, Zeb R, Stunz, Laura L, Vijay, Rahul, Butler, Noah S, Legge, Kevin L, Bishop, Gail A, Maury, Wendy

“…Macrophages are critical in the pathogenesis of a diverse group of viral pathogens, both as targets of infection and for eliciting primary defense mechanisms…”
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Enhanced Toll-like receptor (TLR) responses of TNFR-associated factor 3 (TRAF3)-deficient B lymphocytes by Xie, Ping, Poovassery, Jayakumar, Stunz, Laura L., Smith, Sonja M., Schultz, Mark L., Carlin, Lindsey E., Bishop, Gail A.

“…TRAF3 decreases B‐cell early signals and downstream functions in response to Toll‐like receptors. The key role of TRAF6 in TLR signaling pathways is well…”
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TRAF3 regulates homeostasis of CD8+ central memory T cells by Yi, Zuoan, Stunz, Laura L, Lin, Wai Wai, Bishop, Gail A

“…Our laboratory reported previously that TNF receptor associated factor 3 (TRAF3) is a positive regulator of TCR signaling and T cell function. In the current…”
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TRAF6 is a critical regulator of LMP1 functions in vivo by Arcipowski, Kelly M, Stunz, Laura L, Bishop, Gail A

“…EBV-encoded latent membrane protein 1 (LMP1) is critical for EBV-driven B-cell transformation and most EBV-associated malignancies and is also implicated in…”
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Molecular Mechanisms of TNFR-associated Factor 6 (TRAF6) Utilization by the Oncogenic Viral Mimic of CD40, Latent Membrane Protein 1 (LMP1) by Arcipowski, Kelly M., Stunz, Laura L., Graham, John P., Kraus, Zachary J., Bush, Tony J. Vanden, Bishop, Gail A.

“…Latent membrane protein 1 (LMP1), encoded by Epstein-Barr virus, is required for EBV-mediated B cell transformation and plays a significant role in the…”
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A Novel Mechanism for TNFR-Associated Factor 6-Dependent CD40 Signaling by Rowland, Sarah L, Tremblay, Mikaela M, Ellison, Jason M, Stunz, Laura L, Bishop, Gail A, Hostager, Bruce S

“…Members of the TNFR family play critical roles in the regulation of the immune system. One member of the family critical for efficient activation of…”
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Inhibitory oligonucleotides specifically block effects of stimulatory CpG oligonucleotides in B cells by Stunz, Laura L., Lenert, Petar, Peckham, David, Yi, Ae‐Kyung, Haxhinasto, Sokol, Chang, Ming, Krieg, Arthur M., Ashman, Robert F.

“…Reaction to certain motifs in bacterial DNA is an important function of natural immunity. For example, single stranded oligonucleotides (ODN) containing the…”
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The oncogenic membrane protein LMP1 sequesters TRAF3 in B-cell lymphoma cells to produce functional TRAF3 deficiency by Bangalore-Prakash, Pradeep, Stunz, Laura L., Mambetsariev, Nurbek, Whillock, Amy L., Hostager, Bruce S., Bishop, Gail A.

“…Loss-of-function mutations in genes encoding the signaling protein tumor necrosis factor receptor–associated factor 3 (TRAF3) are commonly found in human…”
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The adaptor TRAF3 restrains the lineage determination of thymic regulatory T cells by modulating signaling via the receptor for IL-2 by Yi, Zuoan, Lin, Wai Wai, Stunz, Laura L, Bishop, Gail A

“…Regulatory T (T reg ) cells require the cytokine IL-2 for their development. Bishop and colleagues show that the adaptor molecule TRAF3 reduces IL-2 receptor…”
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TRAF3 deficiency promotes metabolic reprogramming in B cells by Mambetsariev, Nurbek, Lin, Wai W., Wallis, Alicia M., Stunz, Laura L., Bishop, Gail A.

“…The adaptor protein TNF receptor-associated factor 3 (TRAF3) is a critical regulator of B lymphocyte survival. B cell-specific TRAF3 deficiency results in…”
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CD40-Mediated Maintenance of Immune Homeostasis in the Adipose Tissue Microenvironment by ZUOAN YI, STUNZ, Laura L, BISHOP, Gail A

“…Chronic inflammation in visceral adipose tissue is considered a key element for induction of insulin resistance in obesity. CD40 is required for efficient…”
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