Search Results - "Stunkard, Lee M"

Sulfonate/Nitro Bearing Methylmalonyl-Thioester Isosteres Applied to Methylmalonyl-CoA Decarboxylase Structure–Function Studies by Stunkard, Lee M, Dixon, Austin D, Huth, Tyler J, Lohman, Jeremy R

“…Malonyl-thioesters are reactive centers of malonyl-CoA and malonyl-S-acyl carrier protein, essential to fatty acid, polyketide and various specialized…”
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Structure-Based Prototyping of Allosteric Inhibitors of Human Uridine/Cytidine Kinase 2 (UCK2) by Mashayekh, Siavash, Stunkard, Lee M., Kienle, Maryline, Mathews, Irimpan I., Khosla, Chaitan

“…Pyrimidine nucleotide biosynthesis in humans is a promising chemotherapeutic target for infectious diseases caused by RNA viruses. Because mammalian cells…”
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Structures of LnmK, a Bifunctional Acyltransferase/Decarboxylase, with Substrate Analogues Reveal the Basis for Selectivity and Stereospecificity by Stunkard, Lee M, Kick, Benjamin J, Lohman, Jeremy R

“…LnmK stereospecifically accepts (2R)-methylmalonyl-CoA, generating propionyl-S-acyl carrier protein to support polyketide biosynthesis. LnmK and its homologues…”
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Substrate Enolate Intermediate and Mimic Captured in the Active Site of Streptomyces coelicolor Methylmalonyl‐CoA Epimerase by Stunkard, Lee M., Benjamin, Aaron B., Bower, James B., Huth, Tyler J., Lohman, Jeremy R.

“…Methylmalonyl‐CoA epimerase (MMCE) is proposed to use general acid‐base catalysis, but the proposed catalytic glutamic acids are highly asymmetrical in the…”
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Structures of chloramphenicol acetyltransferase III and Escherichia coli β‐ketoacylsynthase III co‐crystallized with partially hydrolysed acetyl‐oxa(dethia)CoA by Benjamin, Aaron B., Stunkard, Lee M., Ling, Jianheng, Nice, Jaelen N., Lohman, Jeremy R.

“…Acetyl coenzyme A (acetyl‐CoA) is a reactive metabolite that nonproductively hydrolyzes in a number of enzyme active sites in the crystallization time frame…”
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Activity of Fatty Acid Biosynthesis Initiating Ketosynthase FabH with Acetyl/Malonyl-oxa/aza(dethia)CoAs by Boram, Trevor J., Benjamin, Aaron B., Silva de Sousa, Amanda, Stunkard, Lee M., Stewart, Taylor A., Adams, Timothy J., Craft, Nicholas A., Velázquez-Marrero, Kevin G., Ling, Jianheng, Nice, Jaelen N., Lohman, Jeremy R.

“…Fatty acid and polyketide biosynthetic enzymes exploit the reactivity of acyl- and malonyl-thioesters for catalysis. A prime example is FabH, which initiates…”
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Substrate Enolate Intermediate and Mimic Captured in the Active Site of Streptomyces coelicolor Methylmalonyl‐CoA Epimerase by Stunkard, Lee M., Benjamin, Aaron B., Bower, James B., Huth, Tyler J., Lohman, Jeremy R.

“…Abstract Methylmalonyl‐CoA epimerase (MMCE) is proposed to use general acid‐base catalysis, but the proposed catalytic glutamic acids are highly asymmetrical…”
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Abstract 1440: Identification of a novel EGFR sparing brain penetrant ErbB2 inhibitor with activity against oncogenic ErbB2 mutations by Chicarelli, Mark J, Bouhana, Karyn, Brizendine, Richard K., Cable, LouAnn, Crow, Michelle, Fell, Brad, Fischer, John, Fulton, Jennifer, Guarnieri, Anna, Jalluri, Ravi, Knox, Hailey, Koch, Keith A., Rieger, Rob, Robinson, John, Stunkard, Lee M., Sullivan, Francis, Turton, Roy, Winski, Shannon, Zhou, Yeyun

“…Abstract Oncogenic driver mutations in ErbB2 (e.g., S310F/Y, L755S, V777L, V842I) are present in a variety of tumor types including gastric, uterine,…”
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