Search Results - "Stumpp, T."

Half-life extension using serum albumin-binding DARPin® domains by Steiner, Daniel, Merz, Frieder W, Sonderegger, Ivo, Gulotti-Georgieva, Maya, Villemagne, Denis, Phillips, Douglas J, Forrer, Patrik, Stumpp, Michael T, Zitt, Christof, Binz, H Kaspar

“…Abstract A long systemic half-life is key for therapeutic proteins. To that end we have generated serum albumin-binding designed ankyrin repeat domains. These…”
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High-affinity binders selected from designed ankyrin repeat protein libraries by Kohl, Andreas, Forrer, Patrik, Briand, Christophe, Stumpp, Michael T, Binz, H Kaspar, Amstutz, Patrick, Grütter, Markus G, Plückthun, Andreas

“…We report here the evolution of ankyrin repeat (AR) proteins in vitro for specific, high-affinity target binding. Using a consensus design strategy, we…”
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DARPins: A new generation of protein therapeutics by Stumpp, Michael T., Binz, H. Kaspar, Amstutz, Patrick

“…DARPins (designed ankyrin repeat proteins) are a novel class of binding molecules with the potential to overcome limitations of monoclonal antibodies, hence…”
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Comprehensive Survey of Proteins Targeted by Chloroplast Thioredoxin by Motohashi, Ken, Kondoh, Aiko, Stumpp, Michael T., Hisabori, Toru

“…Possible target proteins of chloroplast thioredoxin (Trx) have been investigated in the stroma lysate of spinach chloroplasts. For that purpose, we immobilized…”
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Designing Repeat Proteins: Well-expressed, Soluble and Stable Proteins from Combinatorial Libraries of Consensus Ankyrin Repeat Proteins by Binz, H.Kaspar, Stumpp, Michael T, Forrer, Patrik, Amstutz, Patrick, Plückthun, Andreas

“…We describe an efficient way to generate combinatorial libraries of stable, soluble and well-expressed ankyrin repeat (AR) proteins. Using a combination of…”
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Beyond Antibodies: The DARPin® Drug Platform by Stumpp, Michael T., Dawson, Keith M., Binz, H. Kaspar

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Designed to Be Stable: Crystal Structure of a Consensus Ankyrin Repeat Protein by Kohl, Andreas, Binz, H. Kaspar, Forrer, Patrik, Stumpp, Michael T., Plückthun, Andreas, Grütter, Markus G.

“…Ankyrin repeat (AR) proteins mediate innumerable protein-protein interactions in virtually all phyla. This finding suggested the use of AR proteins as designed…”
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Efficient Tumor Targeting with High-Affinity Designed Ankyrin Repeat Proteins: Effects of Affinity and Molecular Size by ZAHND, Christian, KAWE, Martin, PLÜCKTHUN, Andreas, STUMPP, Michael T, DE PASQUALE, Christine, TAMASKOVIC, Rastislav, NAGY-DAVIDESCU, Gabriela, DREIER, Birgit, SCHIBLI, Roger, KASPAR BINZ, H, WAIBEL, Robert

“…Slow-clearing, tumor-targeting proteins such as monoclonal antibodies typically exhibit high tumor accumulation but low tissue contrast, whereas…”
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A phase 1b/2 study evaluating efficacy and safety of MP0250, a designed ankyrin repeat protein (DARPin) simultaneously targeting vascular endothelial growth factor (VEGF) and hepatocyte growth factor (HGF), in combination with bortezomib and dexamethasone, in patients with relapsed or refractory multiple myeloma by Knop, Stefan, Szarejko, Monika, Grząśko, Norbert, Bringhen, Sara, Trautmann‐Grill, Karolin, Jurczyszyn, Artur, Vacca, Angelo, Khandanpour, Cyrus, Gamberi, Barbara, Pour, Ludek, Iversen, Katrine F., Stumpp, Michael T., Suter, Cosima, Dawson, Keith M., Zitt, Christof, Legenne, Philippe, Stavropoulou, Vaia, Fey, Martin F., Leupin, Nicolas, Goldschmidt, Hartmut

“…MP0250 is a designed ankyrin repeat protein that specifically inhibits both vascular endothelial growth factor A (VEGF‐A) and hepatocyte growth factor (HGF),…”
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Designing Repeat Proteins: Modular Leucine-rich Repeat Protein Libraries Based on the Mammalian Ribonuclease Inhibitor Family by Stumpp, Michael T., Forrer, Patrik, Binz, H.Kaspar, Plückthun, Andreas

“…We present a novel approach to design repeat proteins of the leucine-rich repeat (LRR) family for the generation of libraries of intracellular binding…”
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Intracellular Kinase Inhibitors Selected from Combinatorial Libraries of Designed Ankyrin Repeat Proteins by Amstutz, Patrick, Binz, H. Kaspar, Parizek, Petra, Stumpp, Michael T., Kohl, Andreas, Grütter, Markus G., Forrer, Patrik, Plückthun, Andreas

“…The specific intracellular inhibition of protein activity at the protein level allows the determination of protein function in the cellular context. We…”
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Consensus Design of Repeat Proteins by Forrer, Patrik, Binz, H. Kaspar, Stumpp, Michael T, Plückthun, Andreas

“…Consensus design is a valuable protein-engineering method that is based on statistical information derived from sequence alignments of homologous proteins…”
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Signal sequences directing cotranslational translocation expand the range of proteins amenable to phage display by STEINER, Daniel, FORRER, Patrik, STUMPP, Michael T, PLÜCKTHUN, Andreas

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Carnitine partially protects the rat testis against the late damage produced by doxorubicin administered during pre‐puberty by Cabral, R. E. L., Okada, F. K., Stumpp, T., Vendramini, V., Miraglia, S. M.

“…Summary Doxorubicin, an anticancer drug, is widely included in chemotherapy protocols to combat childhood cancer. Carnitine, an important quaternary amine, is…”
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Beyond Antibodies: The DARPin® Drug Platform by Stumpp, Michael T., Dawson, Keith M., Binz, H. Kaspar

“…The DARPin ® drug platform was established with a vision to expand the medical use of biologics beyond what was possible with monoclonal antibodies. It is…”
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Effects of prenatal and lactation nicotine exposure on rat testicular interstitial tissue by Paccola, C. C., Neves, F. M. O., Cipriano, I., Stumpp, T., Miraglia, S. M.

“…Summary Nicotine is largely consumed as a component of cigarettes. It induces apoptosis, interferes with endocrine function by changing the sex hormones…”
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A novel strategy to design binding molecules harnessing the modular nature of repeat proteins by Forrer, Patrik, Stumpp, Michael T., Binz, H.Kaspar, Plückthun, Andreas

“…Repeat proteins, such as ankyrin or leucine-rich repeat proteins, are ubiquitous binding molecules, which occur, unlike antibodies, intra- and extracellularly…”
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Ensovibep, a SARS‐CoV‐2 antiviral designed ankyrin repeat protein, is safe and well tolerated in healthy volunteers: Results of a first‐in‐human, ascending single‐dose Phase 1 study by Stojcheva, Nina, Gladman, Stacy, Soergel, Marianne, Zitt, Christof, Drake, Roxana, Lockett, Tony, Marchand, Carine, Fustier, Pierre, Stavropoulou, Vaia, Fernandez, Elena, Pettigiani, Nathana Lopes, Watkins, Kate, Puri, Adeep, Watson, Randall, Legenne, Philippe, Stumpp, Michael T., Boyce, Malcolm

“…Aims This study aimed to assess safety, tolerability, pharmacokinetic (PK) and pharmacodynamic (PD) effects of ensovibep, a designed ankyrin repeat protein…”
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The trispecific DARPin ensovibep inhibits diverse SARS-CoV-2 variants by Rothenberger, Sylvia, Hurdiss, Daniel L., Walser, Marcel, Malvezzi, Francesca, Mayor, Jennifer, Ryter, Sarah, Moreno, Hector, Liechti, Nicole, Bosshart, Andreas, Iss, Chloé, Calabro, Valérie, Cornelius, Andreas, Hospodarsch, Tanja, Neculcea, Alexandra, Looser, Thamar, Schlegel, Anja, Fontaine, Simon, Villemagne, Denis, Paladino, Maria, Schiegg, Dieter, Mangold, Susanne, Reichen, Christian, Radom, Filip, Kaufmann, Yvonne, Schaible, Doris, Schlegel, Iris, Zitt, Christof, Sigrist, Gabriel, Straumann, Marcel, Wolter, Julia, Comby, Marco, Sacarcelik, Feyza, Drulyte, Ieva, Lyoo, Heyrhyoung, Wang, Chunyan, Li, Wentao, Du, Wenjuan, Binz, H. Kaspar, Herrup, Rachel, Lusvarghi, Sabrina, Neerukonda, Sabari Nath, Vassell, Russell, Wang, Wei, Adler, Julia M., Eschke, Kathrin, Nascimento, Mariana, Abdelgawad, Azza, Gruber, Achim D., Bushe, Judith, Kershaw, Olivia, Knutson, Charles G., Balavenkatraman, Kamal K., Ramanathan, Krishnan, Wyler, Emanuel, Teixeira Alves, Luiz Gustavo, Lewis, Seth, Watson, Randall, Haeuptle, Micha A., Zürcher, Alexander, Dawson, Keith M., Steiner, Daniel, Weiss, Carol D., Amstutz, Patrick, van Kuppeveld, Frank J. M., Stumpp, Michael T., Bosch, Berend-Jan, Engler, Olivier, Trimpert, Jakob

“…The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants with potential resistance to existing drugs emphasizes the need for new…”
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Treatment of Exudative Age-Related Macular Degeneration with a Designed Ankyrin Repeat Protein that Binds Vascular Endothelial Growth Factor: a Phase I/II Study by Souied, Eric H, Devin, François, Mauget-Faÿsse, Martine, Kolář, Petr, Wolf-Schnurrbusch, Ute, Framme, Carsten, Gaucher, David, Querques, Giuseppe, Stumpp, Michael T, Wolf, Sebastian

“…Purpose To evaluate the safety, tolerability and bioactivity of ascending doses of MP0112, a designed ankyrin repeat protein (DARPin) that binds with high…”
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