Search Results - "Stumpf, Spencer D"
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Pantoea ananatis Genetic Diversity Analysis Reveals Limited Genomic Diversity as Well as Accessory Genes Correlated with Onion Pathogenicity
Published in Frontiers in microbiology (13-02-2018)“…is a member of the family Enterobacteriaceae and an enigmatic plant pathogen with a broad host range. Although strains can be aggressive on onion causing…”
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Critical analysis of polycyclic tetramate macrolactam biosynthetic gene cluster phylogeny and functional diversity
Published in Applied and environmental microbiology (18-06-2024)“…Polycyclic tetramate macrolactams (PTMs) are bioactive natural products commonly associated with certain actinobacterial and proteobacterial lineages. These…”
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Piperazate-Guided Isolation of Caveamides A and B, Cyclohexenylalanine-Containing Nonribosomal Peptides from a Cave Actinomycete
Published in Organic letters (17-05-2024)“…Hybrid genome-mining/15N-NMR was used to target compounds containing piperazate (Piz) residues, leading to the discovery of caveamides A (1) and B (2) from…”
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Discovery of unusual dimeric piperazyl cyclopeptides encoded by a Lentzea flaviverrucosa DSM 44664 biosynthetic supercluster
Published in Proceedings of the National Academy of Sciences - PNAS (26-04-2022)“…Rare actinomycetes represent an underexploited source of new bioactive compounds. Here, we report the use of a targeted metabologenomic approach to identify…”
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Bioinformatic and Functional Evaluation of Actinobacterial Piperazate Metabolism
Published in ACS chemical biology (19-04-2019)“…Piperazate (Piz) is a nonproteinogenic amino acid noted for its unusual N–N bond motif. Piz is a proline mimic that imparts conformational rigidity to…”
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SARS-CoV-2 productively infects primary human immune system cells in vitro and in COVID-19 patients
Published in Journal of molecular cell biology (17-08-2022)“…Abstract The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is associated with a hyperinflammatory state and lymphocytopenia, a…”
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