Search Results - "Stump, W. Tom"

Disrupted mechanobiology links the molecular and cellular phenotypes in familial dilated cardiomyopathy by Clippinger, Sarah R., Cloonan, Paige E., Greenberg, Lina, Ernst, Melanie, Stump, W. Tom, Greenberg, Michael J.

“…Familial dilated cardiomyopathy (DCM) is a leading cause of sudden cardiac death and a major indicator for heart transplant. The disease is frequently caused…”
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SARS-CoV-2 Infects Human Engineered Heart Tissues and Models COVID-19 Myocarditis by Bailey, Adam L., Dmytrenko, Oleksandr, Greenberg, Lina, Bredemeyer, Andrea L., Ma, Pan, Liu, Jing, Penna, Vinay, Winkler, Emma S., Sviben, Sanja, Brooks, Erin, Nair, Ajith P., Heck, Kent A., Rali, Aniket S., Simpson, Leo, Saririan, Mehrdad, Hobohm, Dan, Stump, W. Tom, Fitzpatrick, James A., Xie, Xuping, Zhang, Xianwen, Shi, Pei-Yong, Hinson, J. Travis, Gi, Weng-Tein, Schmidt, Constanze, Leuschner, Florian, Lin, Chieh-Yu, Diamond, Michael S., Greenberg, Michael J., Lavine, Kory J.

“…[Display omitted] •SARS-CoV-2 directly infects cardiomyocytes in patients with COVID-19 myocarditis and does not infect cardiac macrophages, fibroblasts, or…”
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Formation of Tertiary Interactions during rRNA GTPase Center Folding by Rau, Michael J., Welty, Robb, Tom Stump, W., Hall, Kathleen B.

“…The 60-nt GTPase center (GAC) of 23S rRNA has a phylogenetically conserved secondary structure with two hairpin loops and a 3-way junction. It folds into an…”
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Resident cardiac macrophages mediate adaptive myocardial remodeling by Wong, Nicole R., Mohan, Jay, Kopecky, Benjamin J., Guo, Shuchi, Du, Lixia, Leid, Jamison, Feng, Guoshuai, Lokshina, Inessa, Dmytrenko, Oleksandr, Luehmann, Hannah, Bajpai, Geetika, Ewald, Laura, Bell, Lauren, Patel, Nikhil, Bredemeyer, Andrea, Weinheimer, Carla J., Nigro, Jessica M., Kovacs, Attila, Morimoto, Sachio, Bayguinov, Peter O., Fisher, Max.R., Stump, W. Tom, Greenberg, Michael, Fitzpatrick, James A.J., Epelman, Slava, Kreisel, Daniel, Sah, Rajan, Liu, Yongjian, Hu, Hongzhen, Lavine, Kory J.

“…Cardiac macrophages represent a heterogeneous cell population with distinct origins, dynamics, and functions. Recent studies have revealed that C-C Chemokine…”
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Computational Tool for Ensemble Averaging of Single-Molecule Data by Blackwell, Thomas, Stump, W. Tom, Clippinger, Sarah R., Greenberg, Michael J.

“…Molecular motors couple chemical transitions to conformational changes that perform mechanical work in a wide variety of biological processes. Disruption of…”
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Distinct effects of two hearing loss–associated mutations in the sarcomeric myosin MYH7b by Lee, Lindsey A., Barrick, Samantha K., Buvoli, Ada E., Walklate, Jonathan, Stump, W. Tom, Geeves, Michael, Greenberg, Michael J., Leinwand, Leslie A.

“…For decades, sarcomeric myosin heavy chain proteins were assumed to be restricted to striated muscle where they function as molecular motors that contract…”
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Single-molecule mechanics and kinetics of cardiac myosin interacting with regulated thin filaments by Clippinger Schulte, Sarah R., Scott, Brent, Barrick, Samantha K., Stump, W. Tom, Blackwell, Thomas, Greenberg, Michael J.

“…The cardiac cycle is a tightly regulated process wherein the heart generates force to pump blood to the body during systole and then relaxes during diastole…”
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Functional divergence of the sarcomeric myosin, MYH7b, supports species-specific biological roles by Lee, Lindsey A., Barrick, Samantha K., Meller, Artur, Walklate, Jonathan, Lotthammer, Jeffrey M., Tay, Jian Wei, Stump, W. Tom, Bowman, Gregory, Geeves, Michael A., Greenberg, Michael J., Leinwand, Leslie A.

“…Myosin heavy chain 7b (MYH7b) is an evolutionarily ancient member of the sarcomeric myosin family, which typically supports striated muscle function. However,…”
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CRISPR Activation Reverses Haploinsufficiency and Functional Deficits Caused by TTN Truncation Variants by Ghahremani, Shahnaz, Kanwal, Aditya, Pettinato, Anthony, Ladha, Feria, Legere, Nicholas, Thakar, Ketan, Zhu, Yanfen, Tjong, Harianto, Wilderman, Andrea, Stump, W Tom, Greenberg, Lina, Greenberg, Michael J, Cotney, Justin, Wei, Chia-Lin, Hinson, J Travis

“…truncation variants (TTNtvs) are the most common genetic lesion identified in individuals with dilated cardiomyopathy, a disease with high morbidity and…”
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Mechanical dysfunction of the sarcomere induced by a pathogenic mutation in troponin T drives cellular adaptation by Clippinger, Sarah R, Cloonan, Paige E, Wang, Wei, Greenberg, Lina, Stump, W Tom, Angsutararux, Paweorn, Nerbonne, Jeanne M, Greenberg, Michael J

“…Familial hypertrophic cardiomyopathy (HCM), a leading cause of sudden cardiac death, is primarily caused by mutations in sarcomeric proteins. The pathogenesis…”
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Intrinsic flexibility of snRNA hairpin loops facilitates protein binding by Rau, Michael, Stump, W Tom, Hall, Kathleen B

“…Stem-loop II of U1 snRNA and Stem-loop IV of U2 snRNA typically have 10 or 11 nucleotides in their loops. The fluorescent nucleobase 2-aminopurine was used as…”
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Abstract P439: Harnessing Multiscale Models Of A Dilated Cardiomyopathy Mutation For Precision Medicine by Greenberg, Lina, Stump, W. Tom, Bredemeyer, Andrea L, Lavine, Kory J, Greenberg, Michael J

“…Familial dilated cardiomyopathy (DCM) is a leading cause of both adult and pediatric heart failure. Currently, there is no cure for DCM, and the 5-year…”
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Interaction of N-terminal domain of U1A protein with an RNA stem/loop by Hall, Kathleen B., Stump, W. Tom

“…The U1A protein is a sequence-specific RNA binding protein found in the U1 snRNP particle where it binds to stem/loop II of U1 snRNA. U1A contains two ‘RNP’ or…”
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Crosslinking of an iodo-uridine-RNA hairpin to a single site on the human U1A N-terminal RNA binding domain by Stump, W T, Hall, K B

“…The N-terminal RNA binding domain (RBD) of the human U1A snRNP protein binds tightly and specifically to an RNA hairpin that contains a 10-nucleotide loop. The…”
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SP6 RNA polymerase efficiently synthesizes RNA from short double-stranded DNA templates by Stump, W.Tom, Hall, Kathleen B.

“…SP6 DNA-dependent RNA polymerase, like T7 RNA polymerase, can be used to synthesize RNA sequences from short DNA templates which contain the 18 base pair…”
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