Search Results - "Stump, Sascha"

Crystal structure of the major quadruplex formed in the promoter region of the human c-MYC oncogene by Stump, Sascha, Mou, Tung-Chung, Sprang, Stephen R, Natale, Nicholas R, Beall, Howard D

“…The c-MYC oncogene mediates multiple tumor cell survival pathways and is dysregulated or overexpressed in the majority of human cancers. The NHE III1 region of…”
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A Hazard-Based Framework for Identifying Safer Alternatives to Classes of Chemicals: A Case Study on Phthalates in Consumer Products by Smith, Marissa N, Stump, Sascha, van Bergen, Saskia K, Davies, Holly G, Fanning, Elinor, Eaton, Rae, Manahan, Craig C, Sergent, Amber, Zarker, Ken

“…Humans are exposed to hazardous chemicals found in consumer products. In 2019, the Pollution Prevention for Healthy People and Puget Sound Act was passed in…”
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10-N-heterocylic aryl-isoxazole-amides (AIMs) have robust anti-tumor activity against breast and brain cancer cell lines and useful fluorescence properties by Weaver, Matthew J., Stump, Sascha, Campbell, Michael J., Backos, Donald S., Li, Chun, Reigan, Philip, Adams, Earle, Beall, Howard D., Natale, Nicholas R.

“…A series of 10-N-heterocyclic anthracenyl isoxazole amides (N-Het-AIMs) were prepared by Suzuki palladation followed by lanthanide double activation. The…”
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10-Alkoxy-anthracenyl-isoxazole analogs have sub-micromolar activity against a Glioblastoma multiforme cell line by Duncan, Nathan S., Campbell, Michael J., Backos, Donald S., Li, Chun, Rider, Kevin C., Stump, Sascha, Weaver, Matthew J., Gajewski, Mariusz P., Beall, Howard D., Reigan, Philip, Natale, Nicholas R.

“…[Display omitted] A series of 10-alkoxy-Anthryl-isoxazole-pyrrole-doubletails (RO-AIMs) were synthesized using a crown ether assisted nucleophilic aromatic…”
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Structural Characterization of the Human C-Myc Quadruplex and Mechanistic Evaluation of Antitumor Agents: Anthracenyl Isoxazole Amides and Quinolinediones by Stump, Sascha Christian LaMotte

“…Cancer is a disease characterized by the abnormal proliferation of cells in the body. For many forms of cancer, there remain only limited and often ineffective…”
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AIMing towards improved antitumor efficacy by Weaver, Matthew J, Kearns, Alison K, Stump, Sascha, Li, Chun, Gajewski, Mariusz P, Rider, Kevin C, Backos, Donald S, Reigan, Philip R, Beall, Howard D, Natale, Nicholas R

“…Using the structure-activity relationship emerging from previous Letter, and guided by pharmacokinetic properties, new AIMs have been prepared with both…”
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