Search Results - "Stummer, Walter"

5‐ALA in the management of malignant glioma by Stepp, Herbert, Stummer, Walter

“…Background Patients suffering from malignant gliomas have a poor prognosis. For the surgical treatment of these tumors, 5‐aminolevulinic acid (5‐ALA) has…”
Get full text

What is the Surgical Benefit of Utilizing 5-Aminolevulinic Acid for Fluorescence-Guided Surgery of Malignant Gliomas? by Hadjipanayis, Costas G., Widhalm, Georg, Stummer, Walter

“…Abstract The current neurosurgical goal for patients with malignant gliomas is maximal safe resection of the contrast-enhancing tumor. However, a complete…”
Get full text

Fluorescence Guidance and Intraoperative Adjuvants to Maximize Extent of Resection by Orillac, Cordelia, Stummer, Walter, Orringer, Daniel A

“…Abstract Safely maximizing extent of resection has become the central goal in glioma surgery. Especially in eloquent cortex, the goal of maximal resection is…”
Get full text

Randomized, Prospective Double-Blinded Study Comparing 3 Different Doses of 5-Aminolevulinic Acid for Fluorescence-Guided Resections of Malignant Gliomas by Stummer, Walter, Stepp, Herbert, Wiestler, Otmar D, Pichlmeier, Uwe

“…Abstract BACKGROUND: Five-aminolevulinic acid (5-ALA) is used for fluorescence-guided resections of malignant glioma at a dose of 20 mg/kg; yet, it is unknown…”
Get full text

Mechanisms of tumor-related brain edema by Stummer, Walter

“…Cerebral edema contributes strongly to symptoms associated with brain tumors. Although the introduction of corticosteroids has greatly simplified treatment of…”
Get full text

Resection and survival in glioblastoma multiforme: an RTOG recursive partitioning analysis of ALA study patients by Pichlmeier, Uwe, Bink, Andrea, Schackert, Gabriele, Stummer, Walter

“…The benefit of cytoreductive surgery for glioblastoma multiforme (GBM) is unclear, and selection bias in past series has been observed. The 5-aminolevulinic…”
Get full text

Fluorescence-Based Measurement of Real-Time Kinetics of Protoporphyrin IX After 5-Aminolevulinic Acid Administration in Human In Situ Malignant Gliomas by Kaneko, Sadahiro, Suero Molina, Eric, Ewelt, Christian, Warneke, Nils, Stummer, Walter

“…Abstract BACKGROUND Five-aminolevulinic acid (5-ALA) is well established for fluorescence-guided resections of malignant gliomas by eliciting the accumulation…”
Get full text

5-Aminolevulinic Acid Fluorescence-Guided Resection of 18F-FET-PET Positive Tumor Beyond Gadolinium Enhancing Tumor Improves Survival in Glioblastoma by Müther, Michael, Koch, Raphael, Weckesser, Matthias, Sporns, Peter, Schwindt, Wolfram, Stummer, Walter

“…Abstract BACKGROUND The value of early postoperative 18F-FET-PET in patients with glioblastoma (GBM) is unclear. Five-aminolevulinic acid (5-ALA) is used for…”
Get full text

Double dose of 5-aminolevulinic acid and its effect on protoporphyrin IX accumulation in low-grade glioma by Suero Molina, Eric, Black, David, Kaneko, Sadahiro, Müther, Michael, Stummer, Walter

“…Administration of 5-aminolevulinic acid (5-ALA) does not regularly elicit fluorescence in low-grade glioma (LGG) at currently established doses and timing of…”
Get full text

Is Visible Aminolevulinic Acid-Induced Fluorescence an Independent Biomarker for Prognosis in Histologically Confirmed (World Health Organization 2016) Low-Grade Gliomas? by Jaber, Mohammed, Ewelt, Christian, Wölfer, Johannes, Brokinkel, Benjamin, Thomas, Christian, Hasselblatt, Martin, Grauer, Oliver, Stummer, Walter

“…Abstract BACKGROUND Approximately 20% of low-grade gliomas (LGG) display visible protoporphyrin fluorescence during surgery after 5-aminolevulinic acid (5-ALA)…”
Get full text

A ten-year retrospective analysis of decompressive craniectomy or craniotomy after severe brain injury and its implications for donation after brain death by Englbrecht, Jan Sönke, Bajohr, Charis, Zarbock, Alexander, Stummer, Walter, Holling, Markus

“…Craniotomy or decompressive craniectomy are among the therapeutic options to prevent or treat secondary damage after severe brain injury. The choice of…”
Get full text

Protoporphyrin IX in serum of high-grade glioma patients: A novel target for disease monitoring via liquid biopsy by Walke, Anna, Krone, Christopher, Stummer, Walter, König, Simone, Suero Molina, Eric

“…High-grade gliomas (HGG) carry a dismal prognosis. Diagnosis comprises MRI followed by histopathological evaluation of tissue; no blood biomarker is available…”
Get full text

Telomerase activity, TERT expression, hTERT promoter alterations, and alternative lengthening of the telomeres (ALT) in meningiomas – a systematic review by Stögbauer, Louise, Stummer, Walter, Senner, Volker, Brokinkel, Benjamin

“…Telomerase activity and (human) Telomerase Reverse Transcriptase (hTERT) expression are considered hallmarks in oncogenesis of neoplasms and are upregulated by…”
Get full text

How Should We Treat Meningeal Melanocytoma? A Retrospective Analysis of Potential Treatment Strategies by Ricchizzi, Sarah, Gallus, Marco, Stummer, Walter, Holling, Markus

“…Meningeal melanocytomas (MM) are rare primary melanocytic tumors of the leptomeninges with an incidence of 1:10,000,000. Until now, there has been only sparse…”
Get full text

Characterization of autofluorescence and quantitative protoporphyrin IX biomarkers for optical spectroscopy-guided glioma surgery by Black, David, Kaneko, Sadahiro, Walke, Anna, König, Simone, Stummer, Walter, Suero Molina, Eric

“…5-Aminolevulinic acid (5-ALA)-mediated fluorescence does not effectively depict low grade gliomas (LGG) or the infiltrative tumor portion of high-grade gliomas…”
Get full text

Challenges in, and recommendations for, hyperspectral imaging in ex vivo malignant glioma biopsy measurements by Walke, Anna, Black, David, Valdes, Pablo A., Stummer, Walter, König, Simone, Suero-Molina, Eric

“…The visualization of protoporphyrin IX (PPIX) fluorescence with the help of surgical microscopes during 5-aminolevulinic acid-mediated fluorescence-guided…”
Get full text

Prediction of High-Grade Histology and Recurrence in Meningiomas Using Routine Preoperative Magnetic Resonance Imaging: A Systematic Review by Spille, Dorothee Cäcilia, Sporns, Peter B., Heß, Katharina, Stummer, Walter, Brokinkel, Benjamin

“…Estimating the risk of recurrence after surgery remains crucial during care of patients with meningioma. Numerous studies identified correlations of…”
Get full text

Spreading Depolarization Facilitates the Transition of Neuronal Burst Firing from Interictal to Ictal State by Rathmann, Thomas, Khaleghi Ghadiri, Maryam, Stummer, Walter, Gorji, Ali

“…•A complex link between spreading depolarization (SD) and epileptiform burst discharges has been observed.•The effect of SD on the interictal-to-ictal…”
Get full text

Cytoreductive surgery of glioblastoma as the key to successful adjuvant therapies: new arguments in an old discussion by Stummer, Walter, van den Bent, Martin J., Westphal, Manfred

“…Background This article discusses data from 3 randomized phase 3 trials, supporting a role for surgery in glioblastoma. Methods Data were reviewed by extent of…”
Get full text

Diffuse Astrocytoma, IDH-Wildtype: A Dissolving Diagnosis by Hasselblatt, Martin, Jaber, Mohammed, Reuss, David, Grauer, Oliver, Bibo, Annkatrin, Terwey, Stephanie, Schick, Uta, Ebel, Heinrich, Niederstadt, Thomas, Stummer, Walter, von Deimling, Andreas, Paulus, Werner

“…Abstract The histological and molecular features and even the mere existence of diffuse astrocytoma, IDH-wildtype, remain unclear. We therefore examined 212…”
Get full text