Effect of oxytetracycline on metacarpophalangeal and distal interphalangeal joint angles in newborn foals

Thirty-five newborn foals were assigned to 1 of 3 groups and treated with 0.9% NaCl solution (saline; group 1; n = 12), oxytetracycline (44 mg/kg of body weight; group 2; n = 12), or 2-pyrrolidone (oxytetracycline vehicle; group 3; n = 11) in saline solution during the first 36 hours after birth. Se...

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Bibliographic Details
Published in:	Journal of the American Veterinary Medical Association Vol. 204; no. 2; p. 246
Main Authors:	Madison, J B, Garber, J L, Rice, B, Stumf, A J, Zimmer, A E, Ott, E A
Format:	Journal Article
Language:	English
Published:	United States 15-01-1994
Subjects:	Animals Animals, Newborn Blood Urea Nitrogen Congenital Abnormalities - drug therapy Congenital Abnormalities - veterinary Creatinine - blood Forelimb Horses - abnormalities Horses - anatomy & histology Joints - abnormalities Joints - drug effects Kidney - drug effects Oxytetracycline - pharmacology Oxytetracycline - therapeutic use Oxytetracycline - toxicity Pyrrolidinones - pharmacology
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Summary:	Thirty-five newborn foals were assigned to 1 of 3 groups and treated with 0.9% NaCl solution (saline; group 1; n = 12), oxytetracycline (44 mg/kg of body weight; group 2; n = 12), or 2-pyrrolidone (oxytetracycline vehicle; group 3; n = 11) in saline solution during the first 36 hours after birth. Serum biochemical analyses were performed on samples obtained from group-1 and group-2 foals before treatment and 24 and 96 hours after treatment. Lateral to medial radiographic views of the forelimbs were obtained before treatment and 24 and 96 hours after treatment in all foals. Metacarpophalangeal and distal interphalangeal joint angles were measured from the radiographic images. Significant changes in blood chemistry values, other than those typically observed in newborn foals, were not detected. A significant decrease in mean metacarpophalangeal joint angle was observed in foals 24 hours after treatment with oxytetracycline, compared with that in foals of groups 1 and 3. The mean metacarpophalangeal joint angle returned to pretreatment values by 96 hours. Oxytetracycline appears to be an effective method for obtaining a short-term moderate decrease in metacarpophalangeal joint angle in newborn foals.
ISSN:	0003-1488
DOI:	10.2460/javma.1994.204.02.246