Search Results - "Stultz, Collin M."

Machine Learning Improves Risk Stratification After Acute Coronary Syndrome by Myers, Paul D., Scirica, Benjamin M., Stultz, Collin M.

“…The accurate assessment of a patient’s risk of adverse events remains a mainstay of clinical care. Commonly used risk metrics have been based on logistic…”
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Molecular Basis for Specific Regulation of Neuronal Kinesin-3 Motors by Doublecortin Family Proteins by Liu, Judy S., Schubert, Christian R., Fu, Xiaoqin, Fourniol, Franck J., Jaiswal, Jyoti K., Houdusse, Anne, Stultz, Collin M., Moores, Carolyn A., Walsh, Christopher A.

“…Doublecortin (Dcx) defines a growing family of microtubule (MT)-associated proteins (MAPs) involved in neuronal migration and process outgrowth. We show that…”
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Patient contrastive learning: A performant, expressive, and practical approach to electrocardiogram modeling by Diamant, Nathaniel, Reinertsen, Erik, Song, Steven, Aguirre, Aaron D, Stultz, Collin M, Batra, Puneet

“…Supervised machine learning applications in health care are often limited due to a scarcity of labeled training data. To mitigate the effect of small sample…”
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A Structure-free Method for Quantifying Conformational Flexibility in proteins by Burger, Virginia M., Arenas, Daniel J., Stultz, Collin M.

“…All proteins sample a range of conformations at physiologic temperatures and this inherent flexibility enables them to carry out their prescribed functions. A…”
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ECG-guided non-invasive estimation of pulmonary congestion in patients with heart failure by Raghu, Aniruddh, Schlesinger, Daphne, Pomerantsev, Eugene, Devireddy, Srikanth, Shah, Pinak, Garasic, Joseph, Guttag, John, Stultz, Collin M.

“…Quantifying hemodynamic severity in patients with heart failure (HF) is an integral part of clinical care. A key indicator of hemodynamic severity is the mean…”
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Detecting QT prolongation from a single-lead ECG with deep learning by Alam, Ridwan, Aguirre, Aaron, Stultz, Collin M

“…For a number of antiarrhythmics, drug loading requires a 3-day hospitalization with continuous monitoring for QT-prolongation. Automated QT monitoring with…”
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Comparative Studies of Disordered Proteins with Similar Sequences: Application to Aβ40 and Aβ42 by Fisher, Charles K., Ullman, Orly, Stultz, Collin M.

“…Quantitative comparisons of intrinsically disordered proteins (IDPs) with similar sequences, such as mutant forms of the same protein, may provide insights…”
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Using Intramolecular Disulfide Bonds in Tau Protein to Deduce Structural Features of Aggregation-resistant Conformations by Walker, Sophie, Ullman, Orly, Stultz, Collin M.

“…Because tau aggregation likely plays a role in a number of neurodegenerative diseases, understanding the processes that affect tau aggregation is of…”
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Intrinsically Disordered Proteins: Where Computation Meets Experiment by Burger, Virginia, Gurry, Thomas, Stultz, Collin

“…Proteins are heteropolymers that play important roles in virtually every biological reaction. While many proteins have well-defined three-dimensional…”
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Beatquency domain and machine learning improve prediction of cardiovascular death after acute coronary syndrome by Liu, Yun, Scirica, Benjamin M., Stultz, Collin M., Guttag, John V.

“…Frequency domain measures of heart rate variability (HRV) are associated with adverse events after a myocardial infarction. However, patterns in the…”
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What is AI and why should I care? by Stultz, Collin M.

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DeepStrain: A Deep Learning Workflow for the Automated Characterization of Cardiac Mechanics by Morales, Manuel A., van den Boomen, Maaike, Nguyen, Christopher, Kalpathy-Cramer, Jayashree, Rosen, Bruce R., Stultz, Collin M., Izquierdo-Garcia, David, Catana, Ciprian

“…Myocardial strain analysis from cinematic magnetic resonance imaging (cine-MRI) data provides a more thorough characterization of cardiac mechanics than…”
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Perturbing the folding energy landscape of the bacterial immunity protein Im7 by site-specific N-linked glycosylation by Chen, Mark M., Bartlett, Alice I., Nerenberg, Paul S., Friel, Claire T., Hackenberger, Christian P. R., Stultz, Collin M., Radford, Sheena E., Imperiali, Barbara

“…N-linked glycosylation modulates protein folding and stability through a variety of mechanisms. As such there is considerable interest in the development of…”
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Predicting outcomes in patients with aortic stenosis using machine learning: the Aortic Stenosis Risk (ASteRisk) score by Namasivayam, Mayooran, Myers, Paul D, Guttag, John V, Capoulade, Romain, Pibarot, Philippe, Picard, Michael H, Hung, Judy, Stultz, Collin M

“…ObjectiveTo use echocardiographic and clinical features to develop an explainable clinical risk prediction model in patients with aortic stenosis (AS),…”
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Cleavage Site Specificity and Conformational Selection in Type I Collagen Degradation by Salsas-Escat, Ramon, Nerenberg, Paul S, Stultz, Collin M

“…Excessive degradation of type I collagen is associated with a variety of human diseases such as arthritis, tumor metastasis, and atherosclerosis. Methods that…”
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Identifying unreliable predictions in clinical risk models by Myers, Paul D., Ng, Kenney, Severson, Kristen, Kartoun, Uri, Dai, Wangzhi, Huang, Wei, Anderson, Frederick A., Stultz, Collin M.

“…The ability to identify patients who are likely to have an adverse outcome is an essential component of good clinical care. Therefore, predictive risk…”
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Mechanism of Amyloid‑β Fibril Elongation by Gurry, Thomas, Stultz, Collin M

“…Amyloid-β is an intrinsically disordered protein that forms fibrils in the brains of patients with Alzheimer’s disease. To explore factors that affect the…”
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Fibronectin unfolding revisited: modeling cell traction-mediated unfolding of the tenth type-III repeat by Gee, Elaine P S, Ingber, Donald E, Stultz, Collin M

“…Fibronectin polymerization is essential for the development and repair of the extracellular matrix. Consequently, deciphering the mechanism of fibronectin…”
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Constructing ensembles for intrinsically disordered proteins by Fisher, Charles K, Stultz, Collin M

“…► We critically discuss methods for modeling intrinsically disordered proteins. ► Both the advantages and limitations of existing methods are analyzed. ► We…”
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Localized Unfolding of Collagen Explains Collagenase Cleavage Near Imino-poor Sites by Stultz, Collin M

“…Collagenases cleave all three chains of type III collagen at specific sites characterized by a Gly–Leu or a Gly–Ile bond that is upstream from an imino…”
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