Search Results - "Stuetz, Anton"

NVP-LDE225, a potent and selective SMOOTHENED antagonist reduces melanoma growth in vitro and in vivo by Jalili, Ahmad, Mertz, Kirsten D, Romanov, Julia, Wagner, Christine, Kalthoff, Frank, Stuetz, Anton, Pathria, Gaurav, Gschaider, Melanie, Stingl, Georg, Wagner, Stephan N

“…Melanoma is one of the most aggressive cancers and its incidence is increasing worldwide. So far there are no curable therapies especially after metastasis…”
Get full text

Binding of Pimecrolimus and Tacrolimus to Skin and Plasma Proteins: Implications for Systemic Exposure after Topical Application by WEISS, H. Markus, FRESNEAU, Marcel, MOENIUS, Thomas, STUETZ, Anton, BILLICH, Andreas

“…Pimecrolimus and tacrolimus are calcineurin inhibitors used for the topical treatment of atopic dermatitis. Although structurally similar, they display…”
Get full text

Pimecrolimus permeates less than tacrolimus through normal, inflamed, or corticosteroid-pretreated skin by Meingassner, Josef G., Aschauer, Heinrich, Stuetz, Anton, Billich, Andreas

“…:  The permeabilities of normal human and normal, inflamed, or corticosteroid (CS) pretreated skin of young domestic pigs for pimecrolimus and tacrolimus were…”
Get full text

Synthesis and Structure-Activity Relationships of Side-Chain-Substituted Analogs of the Allylamine Antimycotic Terbinafine Lacking the Central Amino Function by Nussbaumer, Peter, Leitner, Ingrid, Mraz, Karin, Stuetz, Anton

“…Terbinafine is a therapeutically used inhibitor of fungal squalene epoxidase that has prompted extensive derivatization programs for structure-activity…”
Get full text

Partnership Among Dermatology, the Society for Investigative Dermatology, and Industry: Suggestions for Change by Stuetz, Anton

Get full text

SPINK5 knockdown in organotypic human skin culture as a model system for Netherton syndrome: effect of genetic inhibition of serine proteases kallikrein 5 and kallikrein 7 by Wang, Shirley, Olt, Sabine, Schoefmann, Nicole, Stuetz, Anton, Winiski, Anthony, Wolff-Winiski, Barbara

“…Netherton syndrome (NS; OMIM 256500) is a genetic skin disease resulting from defects in the serine protease inhibitor Kazal‐type 5 (SPINK5) gene, which…”
Get full text

Topical Treatment of Basal Cell Carcinomas in Nevoid Basal Cell Carcinoma Syndrome with a Smoothened Inhibitor by Skvara, Hans, Kalthoff, Frank, Meingassner, Josef G., Wolff-Winiski, Barbara, Aschauer, Heinrich, Kelleher, Joseph F., Wu, Xu, Pan, Shifeng, Mickel, Lesanka, Schuster, Christopher, Stary, Georg, Jalili, Ahmad, David, Olivier J., Emotte, Corinne, Antunes, Ana Monica Costa, Rose, Kristine, Decker, Jeremy, Carlson, Ilene, Gardner, Humphrey, Stuetz, Anton, Bertolino, Arthur P., Stingl, Georg, De Rie, Menno A.

“…Basal cell carcinoma (BCC) is a distinctive manifestation in nevoid basal cell carcinoma syndrome (NBCCS) patients. Both inherited and acquired mutations of…”
Get full text

Inhibition of Chronic and Acute Skin Inflammation by Treatment with a Vascular Endothelial Growth Factor Receptor Tyrosine Kinase Inhibitor by Halin, Cornelia, Fahrngruber, Hermann, Meingassner, Josef G, Bold, Guido, Littlewood-Evans, Amanda, Stuetz, Anton, Detmar, Michael

“…Although vascular remodeling is a hallmark of many chronic inflammatory disorders, antivascular strategies to treat these conditions have received little…”
Get full text

Percutaneous absorption of drugs used in atopic eczema: pimecrolimus permeates less through skin than corticosteroids and tacrolimus by Billich, Andreas, Aschauer, Heinrich, Aszódi, András, Stuetz, Anton

“…For treatment of skin diseases with topical drugs, penetration of the agents into the relevant layers of the skin is required. Permeation through the skin…”
Get full text

Mechanical and Metabolic Injury to the Skin Barrier Leads to Increased Expression of Murine β-Defensin-1, -3, and -14 by Ahrens, Kerstin, Schunck, Michael, Podda, Graziella-Francesca, Meingassner, Josef, Stuetz, Anton, Schröder, Jens-Michael, Harder, Jürgen, Proksch, Ehrhardt

“…Protection of the skin against microbiological infection is provided by the permeability barrier and by antimicrobial proteins. We asked whether the expression…”
Get full text

Pimecrolimus Enhances TLR2/6-Induced Expression of Antimicrobial Peptides in Keratinocytes by Büchau, Amanda S., Schauber, Jürgen, Hultsch, Thomas, Stuetz, Anton, Gallo, Richard L.

“…Calcineurin inhibitors are potent inhibitors of T-cell-receptor mediated activation of the adaptive immune system. The effects of this class of drug on the…”
Get full text

Synthesis and structure-activity relationships of naftifine-related allylamine antimycotics by Stuetz, Anton, Georgopoulos, Apostolos, Granitzer, Waltraud, Petranyi, Gabor, Berney, Daniel

“…Naftifine (1) is the first representative of the new antifungal allylamine derivatives. Its biological activity is strictly bound to specific structural…”
Get full text

Pharmacological Inhibition of Stearoyl CoA Desaturase in the Skin Induces Atrophy of the Sebaceous Glands by Meingassner, Josef G., Aschauer, Heinrich, Winiski, Anthony P., Dales, Natalie, Yowe, David, Winther, Michael D., Zhang, Zaihui, Stütz, Anton, Billich, Andreas

Get full text

SPINK 5 knockdown in organotypic human skin culture as a model system for N etherton syndrome: effect of genetic inhibition of serine proteases kallikrein 5 and kallikrein 7 by Wang, Shirley, Olt, Sabine, Schoefmann, Nicole, Stuetz, Anton, Winiski, Anthony, Wolff‐Winiski, Barbara

“…Abstract Netherton syndrome ( NS ; OMIM 256500) is a genetic skin disease resulting from defects in the serine protease inhibitor K azal‐type 5 ( SPINK 5)…”
Get full text

Corticosteroids But Not Pimecrolimus Affect Viability, Maturation and Immune Function of Murine Epidermal Langerhans Cells by Hoetzenecker, Wolfram, Meingassner, Josef G., Ecker, Rupert, Stingl, Georg, Stuetz, Anton, Elbe-Bürger, Adelheid

“…Given the importance of dendritic cells in the immune response, we investigated the effect of corticosteroids (CS) on the integrity, survival, and function of…”
Get full text

Pimecrolimus leads to an apoptosis-induced depletion of T cells but not Langerhans cells in patients with atopic dermatitis by Hoetzenecker, Wolfram, Ecker, Rupert, Kopp, Tamara, Stuetz, Anton, Stingl, Georg, Elbe-Bürger, Adelheid

“…Apart from the long-used corticosteroids, topical calcineurin inhibitors (tacrolimus, pimecrolimus) represent novel therapeutic options for the treatment of…”
Get full text

Differential suppression of epidermal antimicrobial protein expression in atopic dermatitis and in EFAD mice by pimecrolimus compared to corticosteroids by Jensen, Jens‐Michael, Ahrens, Kerstin, Meingassner, Josef, Scherer, Andreas, Bräutigam, Matthias, Stütz, Anton, Schwarz, Thomas, Fölster‐Holst, Regina, Harder, Jürgen, Gläser, Regine, Proksch, Ehrhardt

“…:  It has been suggested that the increased rate of bacterial infection in atopic dermatitis (AD) may be caused by reduced antimicrobial protein (AMP)…”
Get full text

Correction: NVP-LDE225, a Potent and Selective SMOOTHENED Antagonist Reduces Melanoma Growth In Vitro and In Vivo by Jalili, Ahmad, Mertz, Kirsten D., Romanov, Julia, Wagner, Christine, Kalthoff, Frank, Stuetz, Anton, Pathria, Gaurav, Gschaider, Melanie, Stingl, Georg, Wagner, Stephan N.

Get full text

Pimecrolimus for the treatment of inflammatory skin disease by Wolff, Klaus, Stuetz, Anton

“…Pimecrolimus (SDZ ASM 981, Elidel ) is an ascomycin macrolactam derivative and a cell-selective inhibitor of inflammatory cytokines specifically developed to…”
Get more information

Discovery of topical calcineurin inhibitors and pharmacological profile of pimecrolimus by Stuetz, Anton, Baumann, Karl, Grassberger, Maximilian, Wolff, Klaus, Meingassner, Josef G

“…Using a newly developed model of allergic contact dermatitis in pigs, calcineurin inhibitors of the tacrolimus and ascomycin type were shown to have a highly…”
Get full text