Search Results - "Studer, Deborah"

The BET inhibitor apabetalone decreases neuroendothelial proinflammatory activation in vitro and in a mouse model of systemic inflammation by Wasiak, Sylwia, Fu, Li, Daze, Emily, Gilham, Dean, Rakai, Brooke D., Stotz, Stephanie C., Tsujikawa, Laura M., Sarsons, Chris D., Studer, Deborah, Rinker, Kristina D., Jahagirdar, Ravi, Wong, Norman C. W., Sweeney, Michael, Johansson, Jan O., Kulikowski, Ewelina

“…Brain vascular inflammation is characterized by endothelial activation and immune cell recruitment to the blood vessel wall, potentially causing a breach in…”
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Linking Aortic Mechanical Properties, Gene Expression and Microstructure: A New Perspective on Regional Weakening in Abdominal Aortic Aneurysms by Forneris, Arianna, Kennard, Jacob, Ismaguilova, Alina, Shepherd, Robert D, Studer, Deborah, Bromley, Amy, Moore, Randy D, Rinker, Kristina D, Di Martino, Elena S

“…Current clinical practice for the assessment of abdominal aortic aneurysms (AAA) is based on vessel diameter and does not account for the multifactorial,…”
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Ribosomal protein l13a as a reference gene for human bone marrow-derived mesenchymal stromal cells during expansion, adipo-, chondro-, and osteogenesis by Studer, Deborah, Lischer, Stefanie, Jochum, Wolfram, Ehrbar, Martin, Zenobi-Wong, Marcy, Maniura-Weber, Katharina

“…In the field of human mesenchymal stromal cell (MSC) research, quantitative real-time reverse transcription-polymerase chain reaction (qPCR) is the method of…”
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Molecular and biophysical mechanisms regulating hypertrophic differentiation in chondrocytes and mesenchymal stem cells by Studer, Deborah, Millan, Christopher, Öztürk, Ece, Maniura-Weber, Katharina, Zenobi-Wong, Marcy

“…Chondrocyte hypertrophy is one of the key physiological processes involved in the longitudinal growth of long bones, yet the regulation of hypertrophy is also…”
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Apabetalone (RVX-208) reduces vascular inflammation in vitro and in CVD patients by a BET-dependent epigenetic mechanism by Tsujikawa, Laura M, Fu, Li, Das, Shovon, Halliday, Christopher, Rakai, Brooke D, Stotz, Stephanie C, Sarsons, Christopher D, Gilham, Dean, Daze, Emily, Wasiak, Sylwia, Studer, Deborah, Rinker, Kristina D, Sweeney, Michael, Johansson, Jan O, Wong, Norman C W, Kulikowski, Ewelina

“…Apabetalone (RVX-208) is a bromodomain and extraterminal protein inhibitor (BETi) that in phase II trials reduced the relative risk (RR) of major adverse…”
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APABETALONE, AN EPIGENETIC BET INHIBITOR IN A PHASE 3 TRIAL, INHIBITS VASCULAR INFLAMMATION AND CELLULAR ADHESION LEADING TO BENEFICIAL OUTCOMES IN CVD PATIENTS by Tsujikawa, Laura, Fu, Li, Das, Shovon, Rakai, Brooke D., Sarsons, Chris D., Halliday, Christopher, Stotz, Stephanie C., Daze, Emily, Wasiak, Sylwia, Studer, Deborah, Dorosz, Sam, Rinker, Kristina D., Sweeney, Michael, Johansson, Jan O., Wong, Norman, Kulikowski, Ewelina

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Abstract 257: Apabetalone (RVX-208) Reduces Pathologic Cell-Cell Adhesion and Expression of Key Vascular Inflammation Markers in Monocytes, Endothelial Cells and Mouse Aorta by Tsujikawa, Laura, Wasiak, Sylwia, Daze, Emily, Sarsons, Chris D, Stotz, Stephanie C, Jahagirdar, Ravi, Studer, Deborah, Rinker, Kristina D, Sweeney, Michael, Johansson, Jan O, Wong, Norman C, Kulikowski, Ewelina

“…Abstract only Apabetalone (RVX-208) is a bromodomain & extraterminal (BET) protein inhibitor, an epigenetic modifier of gene expression, currently in a phase 3…”
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Human chondroprogenitors in alginate–collagen hybrid scaffolds produce stable cartilage in vivo by Studer, Deborah, Cavalli, Emma, Formica, Florian A., Kuhn, Gisela Anne, Salzmann, Gian, Mumme, Marcus, Steinwachs, Matthias R., Laurent‐Applegate, Lee Ann, Maniura‐Weber, Katharina, Zenobi‐Wong, Marcy

“…The goal of this study was to evaluate human epiphyseal chondroprogenitor cells (ECPs) as a potential new cell source for cartilage regeneration. ECPs were…”
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Retrieval of a Metabolite from Cells with Polyelectrolyte Microcapsules by Deborah, Studer, Palankar, Raghavendra, Springer, Sebastian, Winterhalter, Mathias

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Human chondroprogenitors in alginate-collagen hybrid scaffolds produce stable cartilage in vivo: Chondroprogenitors produce stable cartilage in vivo by Studer, Deborah, Cavalli, Emma, Formica, Florian A., Kuhn, Gisela Anne, Salzmann, Gian, Mumme, Marcus, Steinwachs, Matthias R., Laurent-Applegate, Lee Ann, Maniura-Weber, Katharina, Zenobi-Wong, Marcy

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Retrieval of a Metabolite from Cells with Polyelectrolyte Microcapsules by Studer, Deborah, Palankar, Raghavendra, Bédard, Matthieu, Winterhalter, Mathias, Springer, Sebastian

“…To monitor cellular processes in individual cells, it is important to measure the concentrations of intracellular metabolites and to retrieve them for…”
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Retrieval of a Metabolite from Cells with Polyelectrolyte Microcapsules by Studer, Deborah, Palankar, Raghavendra, Springer, Sebastian, Winterhalter, Mathias

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Abstract 14104: Apabetalone (RVX-208) Suppresses Expression of Key Vascular Inflammation Markers in Monocytes, Endothelial Cells and LPS-Challenged Mouse Liver and Monocyte Adhesiveness to Activated Endothelial Cells by Tsujikawa, Laura, Daze, Emily, Fu, Li, Wasiak, Sylwia, Sarsons, Chris D, Halliday, Christopher, Stotz, Stephanie C, Studer, Deborah, Rinker, Kristina D, Jahagirdar, Ravi, Sweeney, Mike, Johansson, Jan, Wong, Norman C, Kulikowski, Ewelina

“…Apabetalone (RVX-208), a small molecule bromodomain & extraterminal (BET) protein inhibitor that selectively targets the second bromodomain (BD2), ameliorates…”
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Design and synthesis of 4-substituted-8-(2-phenyl-cyclohexyl)-2,8-diaza-spiro[4.5]decan-1-one as a novel class of GlyT1 inhibitors: Achieving selectivity against the μ opioid and nociceptin/orphanin FQ peptide (NOP) receptors by Alberati, Daniela, Ceccarelli, Simona M., Jolidon, Synèse, Krafft, Eva A., Kurt, Anke, Maier, Axel, Pinard, Emmanuel, Stalder, Henri, Studer, Deborah, Thomas, Andrew W., Zimmerli, Daniel

“…A novel class of 4-substituted-8-(2-phenyl-cyclohexyl)-2,8-diaza-spiro[4.5]decan-1-ones have been discovered and developed as potent and selective GlyT1…”
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