Search Results - "Stuart, Patrick M"

Developments in Vaccination for Herpes Simplex Virus by Krishnan, Rohini, Stuart, Patrick M

“…Herpes simplex virus (HSV) is an alpha herpes virus, with two subtypes: HSV-1 and HSV-2. HSV is one of the most prevalent sexually transmitted infections. It…”
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Acanthamoeba Keratitis, Pathology, Diagnosis and Treatment by Fanselow, Nicholas, Sirajuddin, Nadia, Yin, Xiao-Tang, Huang, Andrew J W, Stuart, Patrick M

“…keratitis is an unusual corneal infection that is recently increasing in frequency and is often contracted by contact lens wearers, someone who experienced…”
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UVB induced reactivation leads to HSV1 in the corneas of virtually all latently infected mice and requires STING to develop corneal disease by Yin, Xiao-Tang, Hartman, Alexis, Sirajuddin, Nadia, Shukla, Deepak, Leger, Anthony St, Keadle, Tammie L., Stuart, Patrick M.

“…Reactivation of latent herpes simplex type 1 results in virus returning to the cornea leading to recurrent herpetic stromal keratitis (rHSK). We compare two…”
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Dendritic Cell Autophagy Contributes to Herpes Simplex Virus-Driven Stromal Keratitis and Immunopathology by Jiang, Yike, Yin, Xiaotang, Stuart, Patrick M, Leib, David A

“…Herpetic stromal keratitis (HSK) is a blinding ocular disease that is initiated by HSV-1 and characterized by chronic inflammation in the cornea. Although HSK…”
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Anti-IL-17 therapy restricts and reverses late-term corneal allorejection by Yin, Xiao-Tang, Zobell, Stephanie, Jarosz, Jason G, Stuart, Patrick M

“…Corneal allograft rejection has been described as a Th1-mediated process involving IFN-γ production. However, recent evidence also implicated IL-17 as being…”
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Understanding the Role of Chemokines and Cytokines in Experimental Models of Herpes Simplex Keratitis by Azher, Tayaba N., Stuart, Patrick M., Yin, Xiao-Tang

“…Herpes simplex keratitis is a disease of the cornea caused by HSV-1. It is a leading cause of corneal blindness in the world. Underlying molecular mechanism is…”
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Recurrent Herpetic Stromal Keratitis in Mice : A Model for Studying Human HSK by Stuart, Patrick M., Keadle, Tammie L.

“…Herpes simplex virus 1 (HSV-1) infection of the cornea leads to a potentially blinding disease, termed herpetic stromal keratitis (HSK) that is characterized…”
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Sensory Nerve Retraction and Sympathetic Nerve Innervation Contribute to Immunopathology of Murine Recurrent Herpes Stromal Keratitis by Yun, Hongmin, Yin, Xiao-Tang, Stuart, Patrick M, St Leger, Anthony J

“…Herpes stromal keratitis (HSK) represents a spectrum of pathologies which is caused by herpes simplex virus type 1 (HSV-1) infection and is considered a…”
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Role of NK T cells in transplantation with particular emphasis on corneal transplantation by Sirajuddin, Nadia, Yin, Xiao-Tang, Stuart, Patrick M.

“…Natural killer T cells (NKT cells) are a unique subset of the immune system that possess characteristics of both an innate and adaptive immune response. This…”
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Impaired Fas-Fas Ligand Interactions Result in Greater Recurrent Herpetic Stromal Keratitis in Mice by Stuart, Patrick M., Del Rosso, Chelsea R., Potter, Chloe A., Herndon, John, Hard, Jessicah, Keadle, Tammie L., Yin, Xiao-Tang, Ferguson, Thomas A.

“…Herpes simplex virus-1 (HSV-1) infection of the cornea leads to a potentially blinding condition termed herpetic stromal keratitis (HSK). Clinical studies have…”
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CD137 costimulation is associated with reduced herpetic stromal keratitis and with developing normal CD8 + T cells in trigeminal ganglia by Yin, Xiao-Tang, Baugnon, Nicholas K, Krishnan, Rohini, Potter, Chloe A, Yarlagadda, Sudha, Keadle, Tammie L, Stuart, Patrick M

“…Costimulatory interactions can be critical in developing immune responses to infectious agents. We recently reported that herpes simplex type 1 (HSV-1)…”
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CCL3 protects mice from corneal pathology during recurrent HSV-1 infection by Stuart, Patrick M, Morris, Jessica E, Sidhu, Manjaap, Keadle, Tammie L

“…CCL2 and CCL3 are proinflammatory chemokines that are produced during the early stages of inflammation and are known to stimulate the migration of mononuclear…”
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Herpes simplex keratitis: challenges in diagnosis and clinical management by Azher, Tayaba N, Yin, Xiao-Tang, Tajfirouz, Deena, Huang, Andrew Jw, Stuart, Patrick M

“…Herpes simplex virus is responsible for numerous ocular diseases, the most common of which is herpetic stromal keratitis. This is a recurrent infection of the…”
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Fasl-fas interactions regulate neovascularization in the cornea by STUART, Patrick M, FAN PAN, PLAMBECK, Stacey, FERGUSON, Thomas A

“…Neovascularization of the avascular cornea is a significant problem associated with many corneal diseases. Because Fas ligand (FasL) is highly expressed in the…”
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CD28 Costimulation Is Required for Development of Herpetic Stromal Keratitis but Does Not Prevent Establishment of Latency by Yin, Xiao-Tang, Baugnon, Nicholas K, Potter, Chloe A, Tai, Shannon, Keadle, Tammie L, Stuart, Patrick M

“…Corneal infection with herpes simplex virus 1 (HSV-1) leads to infection of trigeminal ganglia (TG), typically followed by the establishment of latency in the…”
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CXCL9 compensates for the absence of CXCL10 during recurrent Herpetic stromal keratitis by Tajfirouz, Deena, West, Devin M, Yin, Xiao-Tang, Potter, Chloe A, Klein, Robyn, Stuart, Patrick M

“…Abstract Herpetic stromal keratitis (HSK) is a disease that is typically associated with reactivation of a latent HSV-1 infection. This disease is driven, in…”
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The role of Fas ligand as an effector molecule in corneal graft rejection by Stuart, Patrick M., Yin, Xiatang, Plambeck, Stacey, Pan, Fan, Ferguson, Thomas A.

“…Previous studies have shown that the expression of Fas ligand (FasL; CD95L) by donor corneas is critical to their survival when placed on allogeneic…”
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CXCL1 but not IL-6 is required for recurrent herpetic stromal keratitis by West, Devin M, Del Rosso, Chelsea R, Yin, Xiao-Tang, Stuart, Patrick M

“…Herpetic stromal keratitis (HSK) is characterized by an inflammatory response that includes neutrophils, macrophages, NK cells, and T cells. The factors that…”
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Effect of Metalloprotease Inhibitors on Corneal Allograft Survival by Stuart, Patrick M, Pan, Fan, Yin, Xiaotang, Haskova, Zdenka, Plambeck, Stacey, Ferguson, Thomas A

“…The expression of Fas ligand (FasL) in the cornea is essential for corneal allograft acceptance in mice. Because the expression of FasL on the surface of cells…”
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Therapeutic Use of Soluble Fas Ligand Ameliorates Acute and Recurrent Herpetic Stromal Keratitis in Mice by Rogge, Megan, Yin, Xiao-Tang, Godfrey, Lisa, Lakireddy, Priya, Potter, Chloe A, Del Rosso, Chelsea R, Stuart, Patrick M

“…The present study was designed to test the therapeutic value of soluble FasL (sFasL) in an acute model of herpetic stromal keratitis (HSK) and, more…”
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