Search Results - "Stuart, Martin"

Circulating giant macrophages as a potential biomarker of solid tumors by Adams, Daniel L., Martin, Stuart S., Alpaugh, Katherine, Charpentier, Monica, Tsai, Susan, Bergan, Raymond C., Ogden, Irene M., Catalona, William, Chumsri, Saranya, Tang, Cha-Mei, Cristofanilli, Massimo

“…Tumor-associated macrophages (TAMs) derived from primary tumors are believed to facilitate circulating tumor cell (CTC) seeding of distant metastases, but the…”
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Insights on CTC Biology and Clinical Impact Emerging from Advances in Capture Technology by Bailey, Patrick C, Martin, Stuart S

“…Circulating tumor cells (CTCs) and circulating tumor microemboli (CTM) have been shown to correlate negatively with patient survival. Actual CTC counts before…”
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Detyrosinated microtubules modulate mechanotransduction in heart and skeletal muscle by Kerr, Jaclyn P., Robison, Patrick, Shi, Guoli, Bogush, Alexey I., Kempema, Aaron M., Hexum, Joseph K., Becerra, Natalia, Harki, Daniel A., Martin, Stuart S., Raiteri, Roberto, Prosser, Benjamin L., Ward, Christopher W.

“…In striated muscle, X-ROS is the mechanotransduction pathway by which mechanical stress transduced by the microtubule network elicits reactive oxygen species…”
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OBSCN restoration via OBSCN-AS1  long-noncoding RNA CRISPR-targeting suppresses metastasis in triple-negative breast cancer by Guardia, Talia, Zhang, Yuqi, Thompson, Keyata N, Lee, Se Jong, Martin, Stuart S, Konstantopoulos, Konstantinos, Kontrogianni-Konstantopoulos, Aikaterini

“…Mounting evidence implicates the giant, cytoskeletal protein obscurin (720 to 870 kDa), encoded by the gene, in the predisposition and development of breast…”
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Polarized NHE1 and SWELL1 regulate migration direction, efficiency and metastasis by Zhang, Yuqi, Li, Yizeng, Thompson, Keyata N., Stoletov, Konstantin, Yuan, Qinling, Bera, Kaustav, Lee, Se Jong, Zhao, Runchen, Kiepas, Alexander, Wang, Yao, Mistriotis, Panagiotis, Serra, Selma A., Lewis, John D., Valverde, Miguel A., Martin, Stuart S., Sun, Sean X., Konstantopoulos, Konstantinos

“…Cell migration regulates diverse (patho)physiological processes, including cancer metastasis. According to the Osmotic Engine Model, polarization of NHE1 at…”
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Distinct roles of tumor associated mutations in collective cell migration by Lee, Rachel M., Vitolo, Michele I., Losert, Wolfgang, Martin, Stuart S.

“…Recent evidence suggests that groups of cells are more likely to form clinically dangerous metastatic tumors, emphasizing the importance of understanding…”
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α-Tubulin acetylation elevated in metastatic and basal-like breast cancer cells promotes microtentacle formation, adhesion, and invasive migration by Boggs, Amanda E, Vitolo, Michele I, Whipple, Rebecca A, Charpentier, Monica S, Goloubeva, Olga G, Ioffe, Olga B, Tuttle, Kimberly C, Slovic, Jana, Lu, Yiling, Mills, Gordon B, Martin, Stuart S

“…Metastatic cases of breast cancer pose the primary challenge in clinical management of this disease, demanding the identification of effective therapeutic…”
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Oxygen Therapy in Critical Illness: Precise Control of Arterial Oxygenation and Permissive Hypoxemia by STUART MARTIN, Daniel, GROCOTT, Michael Patrick William

“…The management of hypoxemia in critically ill patients is challenging. Whilst the harms of tissue hypoxia are well recognized, the possibility of harm from…”
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Microtubules tune mechanotransduction through NOX2 and TRPV4 to decrease sclerostin abundance in osteocytes by Lyons, James S, Joca, Humberto C, Law, Robert A, Williams, Katrina M, Kerr, Jaclyn P, Shi, Guoli, Khairallah, Ramzi J, Martin, Stuart S, Konstantopoulos, Konstantinos, Ward, Christopher W, Stains, Joseph P

“…The adaptation of the skeleton to its mechanical environment is orchestrated by mechanosensitive osteocytes, largely by regulating the abundance of sclerostin,…”
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Circulating Cancer-Associated Macrophage-Like Cells Differentiate Malignant Breast Cancer and Benign Breast Conditions by Adams, Daniel L, Adams, Diane K, Alpaugh, R Katherine, Cristofanilli, Massimo, Martin, Stuart S, Chumsri, Saranya, Tang, Cha-Mei, Marks, Jeffrey R

“…Blood-based testing can be used as a noninvasive method to recover and analyze circulating tumor-derived cells for clinical use. Circulating cancer-associated…”
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Physical confinement alters tumor cell adhesion and migration phenotypes by Balzer, Eric M., Tong, Ziqiu, Paul, Colin D., Hung, Wei‐Chien, Stroka, Kimberly M., Boggs, Amanda E., Martin, Stuart S., Konstantopoulos, Konstantinos

“…Cell migration on planar surfaces is driven by cycles of actin protrusion, integrin‐mediated adhesion, and myosin‐mediated contraction; however, this mechanism…”
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Inactivation of Arid1a in the endometrium is associated with endometrioid tumorigenesis through transcriptional reprogramming by Suryo Rahmanto, Yohan, Shen, Wenjing, Shi, Xu, Chen, Xi, Yu, Yu, Yu, Zheng-Cheng, Miyamoto, Tsutomu, Lee, Meng-Horng, Singh, Vivek, Asaka, Ryoichi, Shimberg, Geoffrey, Vitolo, Michele I., Martin, Stuart S., Wirtz, Denis, Drapkin, Ronny, Xuan, Jianhua, Wang, Tian-Li, Shih, Ie-Ming

“…Somatic inactivating mutations of ARID1A , a SWI/SNF chromatin remodeling gene, are prevalent in human endometrium-related malignancies. To elucidate the…”
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Cytometric characterization of Circulating Tumor Cells Captured by microfiltration and their correlation to the cellsearch® CTC test by Adams, Daniel L., Stefansson, Steingrimur, Haudenschild, Christian, Martin, Stuart S., Charpentier, Monica, Chumsri, Saranya, Cristofanilli, Massimo, Tang, Cha‐Mei, Alpaugh, R. Katherine

“…Recent studies reporting hundreds, to thousands, of circulating tumor cells (CTCs) in the blood of cancer patients have raised questions regarding the…”
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Multipotent cancer stem cells derived from human malignant peritoneal mesothelioma promote tumorigenesis by Varghese, Sheelu, Whipple, Rebecca, Martin, Stuart S, Alexander, H Richard

“…During the progression of malignant peritoneal mesothelioma (MPeM), tumor nodules propagate diffusely within the abdomen and tumors are characterized by…”
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Stimulated Brillouin scattering flow cytometry by Rosvold, Jake R, Zanini, Giulia, Handler, Chenchen, Frank, Eric, Li, Jiarui, Vitolo, Michele I, Martin, Stuart S, Scarcelli, Giuliano

“…We present the use of stimulated Brillouin scattering spectroscopy to achieve rapid measurements of cell biomechanics in a flow cytometer setup. Specifically,…”
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The Mechanical Microenvironment in Breast Cancer by Pratt, Stephen J.P., Lee, Rachel M., Martin, Stuart S.

“…Mechanotransduction is the interpretation of physical cues by cells through mechanosensation mechanisms that elegantly translate mechanical stimuli into…”
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Cod glycopeptide with picomolar affinity to galectin-3 suppresses T-cell apoptosis and prostate cancer metastasis by Guha, Prasun, Kaptan, Engin, Bandyopadhyaya, Gargi, Kaczanowska, Sabina, Davila, Eduardo, Thompson, Keyata, Martin, Stuart S., Kalvakolanu, Dhananjaya V., Vasta, Gerardo R., Ahmed, Hafiz

“…Cancer metastasis and immune suppression are critical issues in cancer therapy. Here, we show that a β-galactoside–binding lectin [galectin-3 (gal3)] that…”
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Molecular Pathways: New Signaling Considerations When Targeting Cytoskeletal Balance to Reduce Tumor Growth by Chakrabarti, Kristi R, Hessler, Lindsay, Bhandary, Lekhana, Martin, Stuart S

“…The dynamic balance between microtubule extension and actin contraction regulates mammalian cell shape, division, and motility, which has made the cytoskeleton…”
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Microtubule disruption reduces metastasis more effectively than primary tumor growth by Thompson, Keyata N, Ju, Julia A, Ory, Eleanor C, Pratt, Stephen J P, Lee, Rachel M, Mathias, Trevor J, Chang, Katarina T, Lee, Cornell J, Goloubeva, Olga G, Bailey, Patrick C, Chakrabarti, Kristi R, Jewell, Christopher M, Vitolo, Michele I, Martin, Stuart S

“…Clinical cancer imaging focuses on tumor growth rather than metastatic phenotypes. The microtubule-depolymerizing drug, Vinorelbine, reduced the metastatic…”
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Curcumin Targets Breast Cancer Stem-like Cells with Microtentacles That Persist in Mammospheres and Promote Reattachment by CHARPENTIER, Monica S, WHIPPLE, Rebecca A, VITOLO, Michele I, BOGGS, Amanda E, SLOVIC, Jana, THOMPSON, Keyata N, BHANDARY, Lekhana, MARTIN, Stuart S

“…Cancer stem-like cells (CSC) and circulating tumor cells (CTC) have related properties associated with distant metastasis, but the mechanisms through which…”
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